Table 1.
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Demographics and Clinical Characteristics of the Cohort of Patients With VZV Encephalitis or Meningoencephalitis

Patient NumberAgea, SexCountryClinical DiagnosisMedical HistoryMRI/CT-C FindingsCSF FindingsDate of Admission Date of Sample Collection
P156, maleSwedenMeningoencephalitisDeep venous thrombosisMRI and CT-C with one-sided prominent temporal horn. No signs of encephalitisCell count: 58/mm3August 16, 2007October 25, 2019
P220, femaleSwedenMeningoencephalitis and Ramsay Hunt syndromeHealthy, recent child deliveryCT-angiography normal, MRI NDCell count: 728/mm3June 29, 2011October 29, 2019
P3 38, maleSwedenMeningoencephalitisHealthyCT-C normal, MRI NDCell count: 594/mm3January 20, 2016November 1, 2019
P422, maleSwedenMeningoencephalitis, vasculitis with ischemic strokeMigraine, asthmaCT-angiography with left-sided temporal infarction, MRI normalCell count: 716/mm3September 07, 2016November 8, 2019
P5 58, maleSwedenVasculitis with subarachnoid hemorrhage HealthyMRI and CT-C with one-sided prominent temporal horn. No signs of encephalitisCell count: 181/mm3January 26, 2004November 8, 2019
P628, maleSwedenMeningoencephalitisHealthyCT-angiography normal, MRI NDCell count: 274/mm3February 22, 2015November 13, 2019
P7 37, femaleSwedenMeningoencephalitisChronic posttraumatic neck and back pain, migraine, chronic fatigue syndrome, earlier motoric function loss diagnosed as dissociative motor disorderCT-C normal, MRI NDCell count: 376/mm3September 15, 2015November 13, 2019
P874, femaleSwedenMeningoencephalitis, Ramsay Hunt syndrome and vasculitisMigraine, anxietyCT-angiography with left-sided temporal infarction, MRI normalCell count: 297/mm3May 10, 2019November 13, 2019
P94, femaleSwedenEncephalitisAsthmaMRI and CT-C with one-sided prominent temporal hornCell count: 102/mm3April 21, 2016November 19, 2019
P1032, femaleSwedenMeningoencephalitisHealthyCT-angiography normal MRI NDCell count: 266/mm3January 30, 2016November 29, 2019
P1158, maleDenmarkMeningoencephalitisHealthyMRI and CT-C normalCell count: 142/mm3February 8, 2019June 12, 2020
P1221, femaleDenmarkEncephalitisHealthyMRI (+angiography) normal Cell count: 585/mm3June 14, 2016July 29, 2019
P1336, femaleDenmarkMeningoencephalitisPolycystic ovary syndromeWhite matter lesionsCell count: 264/mm3October 23, 2019November 14, 2019
P1456, maleDenmarkEncephalitisRheumatoid arthritis treated with MtxMRI normalCell count: 115/mm3June 10, 2016June 30, 2019
P1545, maleSwedenMeningoencephalitis, vasculitis with ischemic strokeDepressionMRI with left-sided thalamic and occipital ischemic lesions, angiography with no signs of vasculitis, but a narrow arteria cerebri posterior sin, CT-C normalCell count: 75/mm3May 18, 2007October 25, 2019
P1625, maleSwedenMeningoencephalitisDelusional disorder, anxiety, recurrent depressive disorderCT-C and MRI normalCell count: 446/mm3May 4, 2011November 8, 2019
P1742, femaleDenmarkEncephalitisBenign intracraniel hypertensionCT-C (+angiography): normal3Cell count: 107/mm3March 3, 2014January 20, 2020
One prior episode of serous meningitis without microbial findings
Patient NumberAgea, SexCountryClinical DiagnosisMedical HistoryMRI/CT-C FindingsCSF FindingsDate of Admission Date of Sample Collection
P156, maleSwedenMeningoencephalitisDeep venous thrombosisMRI and CT-C with one-sided prominent temporal horn. No signs of encephalitisCell count: 58/mm3August 16, 2007October 25, 2019
P220, femaleSwedenMeningoencephalitis and Ramsay Hunt syndromeHealthy, recent child deliveryCT-angiography normal, MRI NDCell count: 728/mm3June 29, 2011October 29, 2019
P3 38, maleSwedenMeningoencephalitisHealthyCT-C normal, MRI NDCell count: 594/mm3January 20, 2016November 1, 2019
P422, maleSwedenMeningoencephalitis, vasculitis with ischemic strokeMigraine, asthmaCT-angiography with left-sided temporal infarction, MRI normalCell count: 716/mm3September 07, 2016November 8, 2019
P5 58, maleSwedenVasculitis with subarachnoid hemorrhage HealthyMRI and CT-C with one-sided prominent temporal horn. No signs of encephalitisCell count: 181/mm3January 26, 2004November 8, 2019
P628, maleSwedenMeningoencephalitisHealthyCT-angiography normal, MRI NDCell count: 274/mm3February 22, 2015November 13, 2019
P7 37, femaleSwedenMeningoencephalitisChronic posttraumatic neck and back pain, migraine, chronic fatigue syndrome, earlier motoric function loss diagnosed as dissociative motor disorderCT-C normal, MRI NDCell count: 376/mm3September 15, 2015November 13, 2019
P874, femaleSwedenMeningoencephalitis, Ramsay Hunt syndrome and vasculitisMigraine, anxietyCT-angiography with left-sided temporal infarction, MRI normalCell count: 297/mm3May 10, 2019November 13, 2019
P94, femaleSwedenEncephalitisAsthmaMRI and CT-C with one-sided prominent temporal hornCell count: 102/mm3April 21, 2016November 19, 2019
P1032, femaleSwedenMeningoencephalitisHealthyCT-angiography normal MRI NDCell count: 266/mm3January 30, 2016November 29, 2019
P1158, maleDenmarkMeningoencephalitisHealthyMRI and CT-C normalCell count: 142/mm3February 8, 2019June 12, 2020
P1221, femaleDenmarkEncephalitisHealthyMRI (+angiography) normal Cell count: 585/mm3June 14, 2016July 29, 2019
P1336, femaleDenmarkMeningoencephalitisPolycystic ovary syndromeWhite matter lesionsCell count: 264/mm3October 23, 2019November 14, 2019
P1456, maleDenmarkEncephalitisRheumatoid arthritis treated with MtxMRI normalCell count: 115/mm3June 10, 2016June 30, 2019
P1545, maleSwedenMeningoencephalitis, vasculitis with ischemic strokeDepressionMRI with left-sided thalamic and occipital ischemic lesions, angiography with no signs of vasculitis, but a narrow arteria cerebri posterior sin, CT-C normalCell count: 75/mm3May 18, 2007October 25, 2019
P1625, maleSwedenMeningoencephalitisDelusional disorder, anxiety, recurrent depressive disorderCT-C and MRI normalCell count: 446/mm3May 4, 2011November 8, 2019
P1742, femaleDenmarkEncephalitisBenign intracraniel hypertensionCT-C (+angiography): normal3Cell count: 107/mm3March 3, 2014January 20, 2020
One prior episode of serous meningitis without microbial findings

Abbreviations: CSF, cerebrospinal fluid; CT-C CAT, scan of the cerebrum; MRI, magnetic resonance imagining; Mtx, methotrexate; N/A, not available; ND, not done; VZV, varicella zoster virus.

aAge stated is the age of each patient upon hospital admission. Date of admission and sample collection are presented as month, day, and year.

Table 1.
Open in new tab

Demographics and Clinical Characteristics of the Cohort of Patients With VZV Encephalitis or Meningoencephalitis

Patient NumberAgea, SexCountryClinical DiagnosisMedical HistoryMRI/CT-C FindingsCSF FindingsDate of Admission Date of Sample Collection
P156, maleSwedenMeningoencephalitisDeep venous thrombosisMRI and CT-C with one-sided prominent temporal horn. No signs of encephalitisCell count: 58/mm3August 16, 2007October 25, 2019
P220, femaleSwedenMeningoencephalitis and Ramsay Hunt syndromeHealthy, recent child deliveryCT-angiography normal, MRI NDCell count: 728/mm3June 29, 2011October 29, 2019
P3 38, maleSwedenMeningoencephalitisHealthyCT-C normal, MRI NDCell count: 594/mm3January 20, 2016November 1, 2019
P422, maleSwedenMeningoencephalitis, vasculitis with ischemic strokeMigraine, asthmaCT-angiography with left-sided temporal infarction, MRI normalCell count: 716/mm3September 07, 2016November 8, 2019
P5 58, maleSwedenVasculitis with subarachnoid hemorrhage HealthyMRI and CT-C with one-sided prominent temporal horn. No signs of encephalitisCell count: 181/mm3January 26, 2004November 8, 2019
P628, maleSwedenMeningoencephalitisHealthyCT-angiography normal, MRI NDCell count: 274/mm3February 22, 2015November 13, 2019
P7 37, femaleSwedenMeningoencephalitisChronic posttraumatic neck and back pain, migraine, chronic fatigue syndrome, earlier motoric function loss diagnosed as dissociative motor disorderCT-C normal, MRI NDCell count: 376/mm3September 15, 2015November 13, 2019
P874, femaleSwedenMeningoencephalitis, Ramsay Hunt syndrome and vasculitisMigraine, anxietyCT-angiography with left-sided temporal infarction, MRI normalCell count: 297/mm3May 10, 2019November 13, 2019
P94, femaleSwedenEncephalitisAsthmaMRI and CT-C with one-sided prominent temporal hornCell count: 102/mm3April 21, 2016November 19, 2019
P1032, femaleSwedenMeningoencephalitisHealthyCT-angiography normal MRI NDCell count: 266/mm3January 30, 2016November 29, 2019
P1158, maleDenmarkMeningoencephalitisHealthyMRI and CT-C normalCell count: 142/mm3February 8, 2019June 12, 2020
P1221, femaleDenmarkEncephalitisHealthyMRI (+angiography) normal Cell count: 585/mm3June 14, 2016July 29, 2019
P1336, femaleDenmarkMeningoencephalitisPolycystic ovary syndromeWhite matter lesionsCell count: 264/mm3October 23, 2019November 14, 2019
P1456, maleDenmarkEncephalitisRheumatoid arthritis treated with MtxMRI normalCell count: 115/mm3June 10, 2016June 30, 2019
P1545, maleSwedenMeningoencephalitis, vasculitis with ischemic strokeDepressionMRI with left-sided thalamic and occipital ischemic lesions, angiography with no signs of vasculitis, but a narrow arteria cerebri posterior sin, CT-C normalCell count: 75/mm3May 18, 2007October 25, 2019
P1625, maleSwedenMeningoencephalitisDelusional disorder, anxiety, recurrent depressive disorderCT-C and MRI normalCell count: 446/mm3May 4, 2011November 8, 2019
P1742, femaleDenmarkEncephalitisBenign intracraniel hypertensionCT-C (+angiography): normal3Cell count: 107/mm3March 3, 2014January 20, 2020
One prior episode of serous meningitis without microbial findings
Patient NumberAgea, SexCountryClinical DiagnosisMedical HistoryMRI/CT-C FindingsCSF FindingsDate of Admission Date of Sample Collection
P156, maleSwedenMeningoencephalitisDeep venous thrombosisMRI and CT-C with one-sided prominent temporal horn. No signs of encephalitisCell count: 58/mm3August 16, 2007October 25, 2019
P220, femaleSwedenMeningoencephalitis and Ramsay Hunt syndromeHealthy, recent child deliveryCT-angiography normal, MRI NDCell count: 728/mm3June 29, 2011October 29, 2019
P3 38, maleSwedenMeningoencephalitisHealthyCT-C normal, MRI NDCell count: 594/mm3January 20, 2016November 1, 2019
P422, maleSwedenMeningoencephalitis, vasculitis with ischemic strokeMigraine, asthmaCT-angiography with left-sided temporal infarction, MRI normalCell count: 716/mm3September 07, 2016November 8, 2019
P5 58, maleSwedenVasculitis with subarachnoid hemorrhage HealthyMRI and CT-C with one-sided prominent temporal horn. No signs of encephalitisCell count: 181/mm3January 26, 2004November 8, 2019
P628, maleSwedenMeningoencephalitisHealthyCT-angiography normal, MRI NDCell count: 274/mm3February 22, 2015November 13, 2019
P7 37, femaleSwedenMeningoencephalitisChronic posttraumatic neck and back pain, migraine, chronic fatigue syndrome, earlier motoric function loss diagnosed as dissociative motor disorderCT-C normal, MRI NDCell count: 376/mm3September 15, 2015November 13, 2019
P874, femaleSwedenMeningoencephalitis, Ramsay Hunt syndrome and vasculitisMigraine, anxietyCT-angiography with left-sided temporal infarction, MRI normalCell count: 297/mm3May 10, 2019November 13, 2019
P94, femaleSwedenEncephalitisAsthmaMRI and CT-C with one-sided prominent temporal hornCell count: 102/mm3April 21, 2016November 19, 2019
P1032, femaleSwedenMeningoencephalitisHealthyCT-angiography normal MRI NDCell count: 266/mm3January 30, 2016November 29, 2019
P1158, maleDenmarkMeningoencephalitisHealthyMRI and CT-C normalCell count: 142/mm3February 8, 2019June 12, 2020
P1221, femaleDenmarkEncephalitisHealthyMRI (+angiography) normal Cell count: 585/mm3June 14, 2016July 29, 2019
P1336, femaleDenmarkMeningoencephalitisPolycystic ovary syndromeWhite matter lesionsCell count: 264/mm3October 23, 2019November 14, 2019
P1456, maleDenmarkEncephalitisRheumatoid arthritis treated with MtxMRI normalCell count: 115/mm3June 10, 2016June 30, 2019
P1545, maleSwedenMeningoencephalitis, vasculitis with ischemic strokeDepressionMRI with left-sided thalamic and occipital ischemic lesions, angiography with no signs of vasculitis, but a narrow arteria cerebri posterior sin, CT-C normalCell count: 75/mm3May 18, 2007October 25, 2019
P1625, maleSwedenMeningoencephalitisDelusional disorder, anxiety, recurrent depressive disorderCT-C and MRI normalCell count: 446/mm3May 4, 2011November 8, 2019
P1742, femaleDenmarkEncephalitisBenign intracraniel hypertensionCT-C (+angiography): normal3Cell count: 107/mm3March 3, 2014January 20, 2020
One prior episode of serous meningitis without microbial findings

Abbreviations: CSF, cerebrospinal fluid; CT-C CAT, scan of the cerebrum; MRI, magnetic resonance imagining; Mtx, methotrexate; N/A, not available; ND, not done; VZV, varicella zoster virus.

aAge stated is the age of each patient upon hospital admission. Date of admission and sample collection are presented as month, day, and year.

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