| . | Mouse . | Human . |
|---|---|---|
| . | N = 6; n = 126 NMJ . | N = 5; n = 151 NMJ . |
| . | 214 tSCs . | 247 tSCs . |
| Number of tSCs per NMJ | 1.74 ± 0.06 | 1.73 ± 0.07 |
| Total tSC perimeter (μm) | 280.80 ± 8.92** | 178.30 ± 6.14 |
| Total tSC area (μm2) | 258.51 ± 8.48** | 199.15 ± 7.11 |
| Synaptic area of tSCs (μm2) | 184.33 ± 6.07**** | 89.27 ± 3.86 |
| Coverage (%) | 68.89 ± 0.71* | 54.14 ± 1.06 |
| Non-synaptic area of tSCs (μm2) | 74.17 ± 3.47**** | 109.88 ± 4.79 |
| Extension (%) | 28.23 ± 0.86** | 54.55 ± 1.27 |
| Unoccupied area of AChR (μm2) | 82.54 ± 2.8 | 65.65 ± 2.84 |
| . | Mouse . | Human . |
|---|---|---|
| . | N = 6; n = 126 NMJ . | N = 5; n = 151 NMJ . |
| . | 214 tSCs . | 247 tSCs . |
| Number of tSCs per NMJ | 1.74 ± 0.06 | 1.73 ± 0.07 |
| Total tSC perimeter (μm) | 280.80 ± 8.92** | 178.30 ± 6.14 |
| Total tSC area (μm2) | 258.51 ± 8.48** | 199.15 ± 7.11 |
| Synaptic area of tSCs (μm2) | 184.33 ± 6.07**** | 89.27 ± 3.86 |
| Coverage (%) | 68.89 ± 0.71* | 54.14 ± 1.06 |
| Non-synaptic area of tSCs (μm2) | 74.17 ± 3.47**** | 109.88 ± 4.79 |
| Extension (%) | 28.23 ± 0.86** | 54.55 ± 1.27 |
| Unoccupied area of AChR (μm2) | 82.54 ± 2.8 | 65.65 ± 2.84 |
In total, 8 separate morphological variables were measured. Values are mean ± SEM (standard error of mean). See Fig. 2 for explanation of derived terms (synaptic area, non-synaptic area, coverage, extension). Unpaired t-test for parametric variables; Mann–Whitney test for non-parametric variables.
P ≤ 0.05,
P ≤ 0.01,
P ≤ 0.0001. AChR, acetylcholine receptors; NMJ, neuromuscular junction; tSCs, terminal Schwann cells.
| . | Mouse . | Human . |
|---|---|---|
| . | N = 6; n = 126 NMJ . | N = 5; n = 151 NMJ . |
| . | 214 tSCs . | 247 tSCs . |
| Number of tSCs per NMJ | 1.74 ± 0.06 | 1.73 ± 0.07 |
| Total tSC perimeter (μm) | 280.80 ± 8.92** | 178.30 ± 6.14 |
| Total tSC area (μm2) | 258.51 ± 8.48** | 199.15 ± 7.11 |
| Synaptic area of tSCs (μm2) | 184.33 ± 6.07**** | 89.27 ± 3.86 |
| Coverage (%) | 68.89 ± 0.71* | 54.14 ± 1.06 |
| Non-synaptic area of tSCs (μm2) | 74.17 ± 3.47**** | 109.88 ± 4.79 |
| Extension (%) | 28.23 ± 0.86** | 54.55 ± 1.27 |
| Unoccupied area of AChR (μm2) | 82.54 ± 2.8 | 65.65 ± 2.84 |
| . | Mouse . | Human . |
|---|---|---|
| . | N = 6; n = 126 NMJ . | N = 5; n = 151 NMJ . |
| . | 214 tSCs . | 247 tSCs . |
| Number of tSCs per NMJ | 1.74 ± 0.06 | 1.73 ± 0.07 |
| Total tSC perimeter (μm) | 280.80 ± 8.92** | 178.30 ± 6.14 |
| Total tSC area (μm2) | 258.51 ± 8.48** | 199.15 ± 7.11 |
| Synaptic area of tSCs (μm2) | 184.33 ± 6.07**** | 89.27 ± 3.86 |
| Coverage (%) | 68.89 ± 0.71* | 54.14 ± 1.06 |
| Non-synaptic area of tSCs (μm2) | 74.17 ± 3.47**** | 109.88 ± 4.79 |
| Extension (%) | 28.23 ± 0.86** | 54.55 ± 1.27 |
| Unoccupied area of AChR (μm2) | 82.54 ± 2.8 | 65.65 ± 2.84 |
In total, 8 separate morphological variables were measured. Values are mean ± SEM (standard error of mean). See Fig. 2 for explanation of derived terms (synaptic area, non-synaptic area, coverage, extension). Unpaired t-test for parametric variables; Mann–Whitney test for non-parametric variables.
P ≤ 0.05,
P ≤ 0.01,
P ≤ 0.0001. AChR, acetylcholine receptors; NMJ, neuromuscular junction; tSCs, terminal Schwann cells.
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
