Summary of serum concentrations (Cmax) of alemtuzumab post infusion (pooled data from CARE-MS I and CARE-MS II)
| . | . | 12 mg . | 24 mg . | ||
|---|---|---|---|---|---|
| Post-infusion serum concentrations (Cmax, ng/ml) . | Treatment . | 1st course . | 2nd course . | 1st course . | 2nd course . |
| n . | 142–144 . | 133–137 . | 46-49 . | 47 . | |
| Mean (s.d.) [min, max] | Day 1 | 1032 (367) | 1101 (420) | 2041 (643) | 2126 (991) |
| [135, 2666] | [0, 2666] | [452, 3942] | [0, 6056] | ||
| Day 3 | 2307 (663) | 2276 (804) | 3500 (948) | 3357 (1198) | |
| [357, 4282] | [974, 5226] | [2073, 7105] | [1452, 7971] | ||
| Day 5 | 3014 (941) | n.a. | 3965 (1037) | n.a. | |
| [911, 5986] | n.a. | [2471, 7388] | n.a. | ||
| Accumulation ratio | 3·1 (0·9) | 2·1 (0·5) | 2·2 (0·9) | 1·6 (0·5) | |
| [1·0, 6·8] | [1·2, 3·9] | [1·0, 6·1] | [0·5, 3·0] | ||
| . | . | 12 mg . | 24 mg . | ||
|---|---|---|---|---|---|
| Post-infusion serum concentrations (Cmax, ng/ml) . | Treatment . | 1st course . | 2nd course . | 1st course . | 2nd course . |
| n . | 142–144 . | 133–137 . | 46-49 . | 47 . | |
| Mean (s.d.) [min, max] | Day 1 | 1032 (367) | 1101 (420) | 2041 (643) | 2126 (991) |
| [135, 2666] | [0, 2666] | [452, 3942] | [0, 6056] | ||
| Day 3 | 2307 (663) | 2276 (804) | 3500 (948) | 3357 (1198) | |
| [357, 4282] | [974, 5226] | [2073, 7105] | [1452, 7971] | ||
| Day 5 | 3014 (941) | n.a. | 3965 (1037) | n.a. | |
| [911, 5986] | n.a. | [2471, 7388] | n.a. | ||
| Accumulation ratio | 3·1 (0·9) | 2·1 (0·5) | 2·2 (0·9) | 1·6 (0·5) | |
| [1·0, 6·8] | [1·2, 3·9] | [1·0, 6·1] | [0·5, 3·0] | ||
Summary of serum concentrations (Cmax) of alemtuzumab post infusion (pooled data from CARE-MS I and CARE-MS II)
| . | . | 12 mg . | 24 mg . | ||
|---|---|---|---|---|---|
| Post-infusion serum concentrations (Cmax, ng/ml) . | Treatment . | 1st course . | 2nd course . | 1st course . | 2nd course . |
| n . | 142–144 . | 133–137 . | 46-49 . | 47 . | |
| Mean (s.d.) [min, max] | Day 1 | 1032 (367) | 1101 (420) | 2041 (643) | 2126 (991) |
| [135, 2666] | [0, 2666] | [452, 3942] | [0, 6056] | ||
| Day 3 | 2307 (663) | 2276 (804) | 3500 (948) | 3357 (1198) | |
| [357, 4282] | [974, 5226] | [2073, 7105] | [1452, 7971] | ||
| Day 5 | 3014 (941) | n.a. | 3965 (1037) | n.a. | |
| [911, 5986] | n.a. | [2471, 7388] | n.a. | ||
| Accumulation ratio | 3·1 (0·9) | 2·1 (0·5) | 2·2 (0·9) | 1·6 (0·5) | |
| [1·0, 6·8] | [1·2, 3·9] | [1·0, 6·1] | [0·5, 3·0] | ||
| . | . | 12 mg . | 24 mg . | ||
|---|---|---|---|---|---|
| Post-infusion serum concentrations (Cmax, ng/ml) . | Treatment . | 1st course . | 2nd course . | 1st course . | 2nd course . |
| n . | 142–144 . | 133–137 . | 46-49 . | 47 . | |
| Mean (s.d.) [min, max] | Day 1 | 1032 (367) | 1101 (420) | 2041 (643) | 2126 (991) |
| [135, 2666] | [0, 2666] | [452, 3942] | [0, 6056] | ||
| Day 3 | 2307 (663) | 2276 (804) | 3500 (948) | 3357 (1198) | |
| [357, 4282] | [974, 5226] | [2073, 7105] | [1452, 7971] | ||
| Day 5 | 3014 (941) | n.a. | 3965 (1037) | n.a. | |
| [911, 5986] | n.a. | [2471, 7388] | n.a. | ||
| Accumulation ratio | 3·1 (0·9) | 2·1 (0·5) | 2·2 (0·9) | 1·6 (0·5) | |
| [1·0, 6·8] | [1·2, 3·9] | [1·0, 6·1] | [0·5, 3·0] | ||
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