Table 1.
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Adjusted Ceftolozane-tazobactam Dosing Used at The Johns Hopkins Hospital, According to Renal Function

Creatinine Clearance (mL/min)3 grams every 8 hours1.5 grams every 8 hours
>50 mL/minNormal doseNormal dose
30–50 mL/min1.5 g Q8H750 mg Q8H
15–29 mL/min750 mg Q8H375 mg Q8H
<15 mL/min or intermittent hemodialysisLoad with 2.25 g, then 450 mg Q8HLoad with 750 mg, then 150 mg Q8H
CVVHD with dialysis flow rate <1.6 L/h750 mg Q8H375 mg Q8H
CVVHD with dialysis flow rate 1.6–2.9 L/h1.5 g Q8H750 mg Q8H
CVVHD with dialysis flow rate >2.9 L/h3 g Q8H1.5 g Q8H
Creatinine Clearance (mL/min)3 grams every 8 hours1.5 grams every 8 hours
>50 mL/minNormal doseNormal dose
30–50 mL/min1.5 g Q8H750 mg Q8H
15–29 mL/min750 mg Q8H375 mg Q8H
<15 mL/min or intermittent hemodialysisLoad with 2.25 g, then 450 mg Q8HLoad with 750 mg, then 150 mg Q8H
CVVHD with dialysis flow rate <1.6 L/h750 mg Q8H375 mg Q8H
CVVHD with dialysis flow rate 1.6–2.9 L/h1.5 g Q8H750 mg Q8H
CVVHD with dialysis flow rate >2.9 L/h3 g Q8H1.5 g Q8H

Abbreviation: CVVHD, continuous venovenous hemodialysis.

Table 1.
Open in new tab

Adjusted Ceftolozane-tazobactam Dosing Used at The Johns Hopkins Hospital, According to Renal Function

Creatinine Clearance (mL/min)3 grams every 8 hours1.5 grams every 8 hours
>50 mL/minNormal doseNormal dose
30–50 mL/min1.5 g Q8H750 mg Q8H
15–29 mL/min750 mg Q8H375 mg Q8H
<15 mL/min or intermittent hemodialysisLoad with 2.25 g, then 450 mg Q8HLoad with 750 mg, then 150 mg Q8H
CVVHD with dialysis flow rate <1.6 L/h750 mg Q8H375 mg Q8H
CVVHD with dialysis flow rate 1.6–2.9 L/h1.5 g Q8H750 mg Q8H
CVVHD with dialysis flow rate >2.9 L/h3 g Q8H1.5 g Q8H
Creatinine Clearance (mL/min)3 grams every 8 hours1.5 grams every 8 hours
>50 mL/minNormal doseNormal dose
30–50 mL/min1.5 g Q8H750 mg Q8H
15–29 mL/min750 mg Q8H375 mg Q8H
<15 mL/min or intermittent hemodialysisLoad with 2.25 g, then 450 mg Q8HLoad with 750 mg, then 150 mg Q8H
CVVHD with dialysis flow rate <1.6 L/h750 mg Q8H375 mg Q8H
CVVHD with dialysis flow rate 1.6–2.9 L/h1.5 g Q8H750 mg Q8H
CVVHD with dialysis flow rate >2.9 L/h3 g Q8H1.5 g Q8H

Abbreviation: CVVHD, continuous venovenous hemodialysis.

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