Table 3. Open in new tab Adverse...

Outcomes at Hospital Discharge (No. of Surviving Patients With Invasive Hia)	Meningitis (n = 41)		Bacteremic Pneumonia (n = 58)		Bacteremia^a (n = 49)		All Clinical Presentations^b (n = 152)
Any clinical adverse outcome	18	43.9	8	13.8	1	2.0	27	17.7
Seizures/seizure disorders	10	24.4	0	0.0	0	0.0	10	6.5
Hearing loss	9	22.0	0	0.0	0	0.0	9	5.9
Oxygen dependence	0	0.0	8	13.8	0	0.0	8	5.2
Neurological deficits	4	9.8	0	0.0	0	0.0	4	2.6
Motor deficits	1	2.4	1	1.7	0	0.0	2	1.3
Cognitive impairments	0	0.0	2	3.5	0	0.0	2	1.3
Developmental delay	2	4.9	0	0.0	0	0.0	2	1.3
Paralysis	1	2.4	0	0.0	0	0.0	1	0.7
Cranial nerve dysfunction/palsy	1	2.4	0	0.0	0	0.0	1	0.7
Joint or bone abnormality	0	0.0	0	0.0	1	2.0	1	0.7
Ventriculomegaly	1	2.4	0	0.0	0	0.0	1	0.7
Outcomes 1 Year After Hia Disease Onset (No. Who Had Chart Available 1 Year After Hia Disease Onset)	Meningitis^c(n = 33)		Bacteremic Pneumonia (n = 42)		Bacteremia^d(n = 42)		All Clinical Presentations^e(n = 118)
	No.	%	No.	%	No.	%	No.	%
Any adverse clinical outcome	16	48.5	2	4.8	3	7.1	21	17.8
Hearing loss	10	30.3	0	0.0	0	0.0	10	8.5
Developmental delay	4	12.1	0	0.0	0	0.0	4	3.4
Speech delay	4	12.1	0	0.0	0	0.0	4	3.4
Seizures/seizure disorders	3	9.1	0	0.0	0	0.0	3	2.5
Cranial nerve dysfunction/palsy	2	6.1	0	0.0	0	0.0	2	1.7
Motor deficits	1	3.0	0	0.0	1	2.4	2	1.7
Recurrent pneumonia	0	0.0	1	2.4	1	2.4	2	1.7
Neurological deficits	0	0.0	0	0.0	1	2.4	1	0.9
Ventriculomegaly	1	3.0	0	0.0	0	0.0	1	0.9
Other long-term sequelae	0	0.0	1	2.4	0	0.0	1	0.9
Vision loss	1	3.0	0	0.0	0	0.0	1	0.9

Outcomes at Hospital Discharge (No. of Surviving Patients With Invasive Hia)

Meningitis (n = 41)

Bacteremic Pneumonia (n = 58)

Bacteremia^a (n = 49)

All Clinical Presentations^b (n = 152)

No.

Any clinical adverse outcome

43.9

13.8

2.0

17.7

Seizures/seizure disorders

24.4

0.0

6.5

Hearing loss

22.0

0.0

5.9

Oxygen dependence

0.0

13.8

0.0

5.2

Neurological deficits

9.8

0.0

2.6

Motor deficits

2.4

1.7

0.0

1.3

Cognitive impairments

0.0

3.5

0.0

1.3

Developmental delay

4.9

0.0

1.3

Paralysis

2.4

0.0

0.7

Cranial nerve dysfunction/palsy

2.4

0.0

0.7

Joint or bone abnormality

0.0

2.0

0.7

Ventriculomegaly

2.4

0.0

0.7

Outcomes 1 Year After Hia Disease Onset (No. Who Had Chart Available 1 Year After Hia Disease Onset)

Meningitis^c(n = 33)

Bacteremic Pneumonia (n = 42)

Bacteremia^d(n = 42)

All Clinical Presentations^e(n = 118)

No.

Any adverse clinical outcome

48.5

4.8

7.1

17.8

Hearing loss

30.3

0.0

8.5

Developmental delay

12.1

0.0

3.4

Speech delay

12.1

0.0

3.4

Seizures/seizure disorders

9.1

0.0

2.5

Cranial nerve dysfunction/palsy

6.1

0.0

1.7

Motor deficits

3.0

0.0

2.4

1.7

Recurrent pneumonia

0.0

2.4

1.7

Neurological deficits

0.0

2.4

0.9

Ventriculomegaly

3.0

0.0

0.9

Other long-term sequelae

0.0

2.4

0.0

0.9

Vision loss

3.0

0.0

0.9

Outcomes at Hospital Discharge (No. of Surviving Patients With Invasive Hia)	Meningitis (n = 41)		Bacteremic Pneumonia (n = 58)		Bacteremia^a (n = 49)		All Clinical Presentations^b (n = 152)
Any clinical adverse outcome	18	43.9	8	13.8	1	2.0	27	17.7
Seizures/seizure disorders	10	24.4	0	0.0	0	0.0	10	6.5
Hearing loss	9	22.0	0	0.0	0	0.0	9	5.9
Oxygen dependence	0	0.0	8	13.8	0	0.0	8	5.2
Neurological deficits	4	9.8	0	0.0	0	0.0	4	2.6
Motor deficits	1	2.4	1	1.7	0	0.0	2	1.3
Cognitive impairments	0	0.0	2	3.5	0	0.0	2	1.3
Developmental delay	2	4.9	0	0.0	0	0.0	2	1.3
Paralysis	1	2.4	0	0.0	0	0.0	1	0.7
Cranial nerve dysfunction/palsy	1	2.4	0	0.0	0	0.0	1	0.7
Joint or bone abnormality	0	0.0	0	0.0	1	2.0	1	0.7
Ventriculomegaly	1	2.4	0	0.0	0	0.0	1	0.7
Outcomes 1 Year After Hia Disease Onset (No. Who Had Chart Available 1 Year After Hia Disease Onset)	Meningitis^c(n = 33)		Bacteremic Pneumonia (n = 42)		Bacteremia^d(n = 42)		All Clinical Presentations^e(n = 118)
	No.	%	No.	%	No.	%	No.	%
Any adverse clinical outcome	16	48.5	2	4.8	3	7.1	21	17.8
Hearing loss	10	30.3	0	0.0	0	0.0	10	8.5
Developmental delay	4	12.1	0	0.0	0	0.0	4	3.4
Speech delay	4	12.1	0	0.0	0	0.0	4	3.4
Seizures/seizure disorders	3	9.1	0	0.0	0	0.0	3	2.5
Cranial nerve dysfunction/palsy	2	6.1	0	0.0	0	0.0	2	1.7
Motor deficits	1	3.0	0	0.0	1	2.4	2	1.7
Recurrent pneumonia	0	0.0	1	2.4	1	2.4	2	1.7
Neurological deficits	0	0.0	0	0.0	1	2.4	1	0.9
Ventriculomegaly	1	3.0	0	0.0	0	0.0	1	0.9
Other long-term sequelae	0	0.0	1	2.4	0	0.0	1	0.9
Vision loss	1	3.0	0	0.0	0	0.0	1	0.9

Table 3.

Open in new tab

Adverse Clinical Outcomes Recorded at Time of Hospital Discharge and 1 Year After Haemophilus influenzae Serotype a Disease Onset Among Patients Who Had Adverse Clinical Outcomes by Medical Record Review, Overall and by Clinical Presentation, 2011–2015

Outcomes at Hospital Discharge (No. of Surviving Patients With Invasive Hia)	Meningitis (n = 41)		Bacteremic Pneumonia (n = 58)		Bacteremia^a (n = 49)		All Clinical Presentations^b (n = 152)
	No.	%	No.	%	No.	%	No.	%
Any clinical adverse outcome	18	43.9	8	13.8	1	2.0	27	17.7
Seizures/seizure disorders	10	24.4	0	0.0	0	0.0	10	6.5
Hearing loss	9	22.0	0	0.0	0	0.0	9	5.9
Oxygen dependence	0	0.0	8	13.8	0	0.0	8	5.2
Neurological deficits	4	9.8	0	0.0	0	0.0	4	2.6
Motor deficits	1	2.4	1	1.7	0	0.0	2	1.3
Cognitive impairments	0	0.0	2	3.5	0	0.0	2	1.3
Developmental delay	2	4.9	0	0.0	0	0.0	2	1.3
Paralysis	1	2.4	0	0.0	0	0.0	1	0.7
Cranial nerve dysfunction/palsy	1	2.4	0	0.0	0	0.0	1	0.7
Joint or bone abnormality	0	0.0	0	0.0	1	2.0	1	0.7
Ventriculomegaly	1	2.4	0	0.0	0	0.0	1	0.7
Outcomes 1 Year After Hia Disease Onset (No. Who Had Chart Available 1 Year After Hia Disease Onset)	Meningitis^c(n = 33)		Bacteremic Pneumonia (n = 42)		Bacteremia^d(n = 42)		All Clinical Presentations^e(n = 118)
	No.	%	No.	%	No.	%	No.	%
Any adverse clinical outcome	16	48.5	2	4.8	3	7.1	21	17.8
Hearing loss	10	30.3	0	0.0	0	0.0	10	8.5
Developmental delay	4	12.1	0	0.0	0	0.0	4	3.4
Speech delay	4	12.1	0	0.0	0	0.0	4	3.4
Seizures/seizure disorders	3	9.1	0	0.0	0	0.0	3	2.5
Cranial nerve dysfunction/palsy	2	6.1	0	0.0	0	0.0	2	1.7
Motor deficits	1	3.0	0	0.0	1	2.4	2	1.7
Recurrent pneumonia	0	0.0	1	2.4	1	2.4	2	1.7
Neurological deficits	0	0.0	0	0.0	1	2.4	1	0.9
Ventriculomegaly	1	3.0	0	0.0	0	0.0	1	0.9
Other long-term sequelae	0	0.0	1	2.4	0	0.0	1	0.9
Vision loss	1	3.0	0	0.0	0	0.0	1	0.9

Outcomes at Hospital Discharge (No. of Surviving Patients With Invasive Hia)	Meningitis (n = 41)		Bacteremic Pneumonia (n = 58)		Bacteremia^a (n = 49)		All Clinical Presentations^b (n = 152)
	No.	%	No.	%	No.	%	No.	%
Any clinical adverse outcome	18	43.9	8	13.8	1	2.0	27	17.7
Seizures/seizure disorders	10	24.4	0	0.0	0	0.0	10	6.5
Hearing loss	9	22.0	0	0.0	0	0.0	9	5.9
Oxygen dependence	0	0.0	8	13.8	0	0.0	8	5.2
Neurological deficits	4	9.8	0	0.0	0	0.0	4	2.6
Motor deficits	1	2.4	1	1.7	0	0.0	2	1.3
Cognitive impairments	0	0.0	2	3.5	0	0.0	2	1.3
Developmental delay	2	4.9	0	0.0	0	0.0	2	1.3
Paralysis	1	2.4	0	0.0	0	0.0	1	0.7
Cranial nerve dysfunction/palsy	1	2.4	0	0.0	0	0.0	1	0.7
Joint or bone abnormality	0	0.0	0	0.0	1	2.0	1	0.7
Ventriculomegaly	1	2.4	0	0.0	0	0.0	1	0.7
Outcomes 1 Year After Hia Disease Onset (No. Who Had Chart Available 1 Year After Hia Disease Onset)	Meningitis^c(n = 33)		Bacteremic Pneumonia (n = 42)		Bacteremia^d(n = 42)		All Clinical Presentations^e(n = 118)
	No.	%	No.	%	No.	%	No.	%
Any adverse clinical outcome	16	48.5	2	4.8	3	7.1	21	17.8
Hearing loss	10	30.3	0	0.0	0	0.0	10	8.5
Developmental delay	4	12.1	0	0.0	0	0.0	4	3.4
Speech delay	4	12.1	0	0.0	0	0.0	4	3.4
Seizures/seizure disorders	3	9.1	0	0.0	0	0.0	3	2.5
Cranial nerve dysfunction/palsy	2	6.1	0	0.0	0	0.0	2	1.7
Motor deficits	1	3.0	0	0.0	1	2.4	2	1.7
Recurrent pneumonia	0	0.0	1	2.4	1	2.4	2	1.7
Neurological deficits	0	0.0	0	0.0	1	2.4	1	0.9
Ventriculomegaly	1	3.0	0	0.0	0	0.0	1	0.9
Other long-term sequelae	0	0.0	1	2.4	0	0.0	1	0.9
Vision loss	1	3.0	0	0.0	0	0.0	1	0.9

Abbreviation: Hia, Haemophilus influenzae serotype a.

^aThe patient who had the adverse outcome at hospital discharge had both bacteremia and septic arthritis.

^bAll clinical presentations include meningitis (n = 41), bacteremic pneumonia (n = 58), bacteremia (n = 49), septic arthritis (n = 3), and septic arthritis and abscess (n = 1).

^cOne patient with both meningitis and septic arthritis had hearing loss reported 1 year after Hia disease onset.

^dOne patient with both bacteremia and septic arthritis had motor deficits reported 1 year after Hia disease onset.

^eAll clinical presentations include meningitis (n = 33), bacteremic pneumonia (n = 42), bacteremia (n = 42), and septic arthritis (n = 1).

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