Table 2: Open in new tab Measurements in...

Parameter	ECCP INF (n = 8)	EBCP INF (n = 8)	Cala INF (n = 8)	P-value
LVpdP
Baseline (mmHg)	91.0 ± 28.2	93.1 ± 26.8	82.0 ± 17.8	0.64
30-min reperfusion (%)	125.1 ± 43.3	131.6 ± 81.4	70.6 ± 31.2	0.081
90-min reperfusion (%)	84.9 ± 46.1	88.6 ± 55.0	56.3 ± 25.8	0.30
dLVP/dt_max
Baseline (mmHg/s)	2752 ± 831	2808 ± 856	2298 ± 506	0.35
30-min reperfusion (%)	130.6 ± 41.3	133.6 ± 68.0	89.1 ± 40.6	0.18
90-min reperfusion (%)	99.3 ± 40.6	103.3 ± 60.1	78.7 ± 40.5	0.56
dLVP/dt_min
Baseline (mmHg/s)	−2113 ± 716	−2182 ± 774	−1824 ± 357	0.51
30-min reperfusion (%)	127.4 ± 44.2	121.5 ± 64.8	78.6 ± 37.4	0.13
90-min reperfusion (%)	93.3 ± 41.7	88.5 ± 55.8	68.5 ± 35.1	0.52
Heart rate
Baseline (beats/min)	226.7 ± 33.3	207.6 ± 41.5	251.6 ± 48.1	0.13
30-min reperfusion (%)	84.6 ± 12.4	79.8 ± 23.2	82.3 ± 26.2	0.91
90-min reperfusion (%)	85.6 ± 15.0	72.9 ± 32.0	71.2 ± 32.5	0.54
Coronary blood flow
Baseline (ml/min)	3.8 ± 0.5	4.4 ± 0.9	4.4 ± 1.2	0.35
30-min reperfusion (%)	136.5 ± 52.9^*	147.2 ± 62.0^*	62.2 ± 41.4	0.008
90-min reperfusion (%)	75.6 ± 26.1	80.9 ± 37.9	53.8 ± 49.0	0.35
Oxygen consumption
Baseline [ml/(min 100 g)]	9.36 ± 1.29	9.36 ± 1.66	9.14 ± 5.70	0.99
10-min reperfusion (%)	123.0 ± 45.5	78.8 ± 30.6	72.9 ± 64.3	0.10
90-min reperfusion (%)	76.5 ± 30.9	91.3 ± 52.2	55.0 ± 54.3	0.32
Lactate production
Baseline [µmol/(ml min)]	0.52 ± 0.36	0.24 ± 0.51	0.04 ± 0.43	0.11
10-min reperfusion [µmol/(ml min)]	2.01 ± 0.88^*	1.32 ± 0.68	1.01 ± 0.56	0.032
90-min reperfusion [µmol/(ml min)]	1.43 ± 0.54^#	0.58 ± 0.71	1.04 ± 0.40	0.022

Parameter

ECCP INF (n = 8)

EBCP INF (n = 8)

Cala INF (n = 8)

P-value

LVpdP

Baseline (mmHg)

91.0 ± 28.2

93.1 ± 26.8

82.0 ± 17.8

0.64

30-min reperfusion (%)

125.1 ± 43.3

131.6 ± 81.4

70.6 ± 31.2

0.081

90-min reperfusion (%)

84.9 ± 46.1

88.6 ± 55.0

56.3 ± 25.8

0.30

dLVP/dt_max

Baseline (mmHg/s)

2752 ± 831

2808 ± 856

2298 ± 506

0.35

30-min reperfusion (%)

130.6 ± 41.3

133.6 ± 68.0

89.1 ± 40.6

0.18

90-min reperfusion (%)

99.3 ± 40.6

103.3 ± 60.1

78.7 ± 40.5

0.56

dLVP/dt_min

Baseline (mmHg/s)

−2113 ± 716

−2182 ± 774

−1824 ± 357

0.51

30-min reperfusion (%)

127.4 ± 44.2

121.5 ± 64.8

78.6 ± 37.4

0.13

90-min reperfusion (%)

93.3 ± 41.7

88.5 ± 55.8

68.5 ± 35.1

0.52

Heart rate

Baseline (beats/min)

226.7 ± 33.3

207.6 ± 41.5

251.6 ± 48.1

0.13

30-min reperfusion (%)

84.6 ± 12.4

79.8 ± 23.2

82.3 ± 26.2

0.91

90-min reperfusion (%)

85.6 ± 15.0

72.9 ± 32.0

71.2 ± 32.5

0.54

Coronary blood flow

Baseline (ml/min)

3.8 ± 0.5

4.4 ± 0.9

4.4 ± 1.2

0.35

30-min reperfusion (%)

136.5 ± 52.9^*

147.2 ± 62.0^*

62.2 ± 41.4

0.008

90-min reperfusion (%)

75.6 ± 26.1

80.9 ± 37.9

53.8 ± 49.0

0.35

Oxygen consumption

Baseline [ml/(min 100 g)]

9.36 ± 1.29

9.36 ± 1.66

9.14 ± 5.70

0.99

10-min reperfusion (%)

123.0 ± 45.5

78.8 ± 30.6

72.9 ± 64.3

0.10

90-min reperfusion (%)

76.5 ± 30.9

91.3 ± 52.2

55.0 ± 54.3

0.32

Lactate production

Baseline [µmol/(ml min)]

0.52 ± 0.36

0.24 ± 0.51

0.04 ± 0.43

0.11

10-min reperfusion [µmol/(ml min)]

2.01 ± 0.88^*

1.32 ± 0.68

1.01 ± 0.56

0.032

90-min reperfusion [µmol/(ml min)]

1.43 ± 0.54^#

0.58 ± 0.71

1.04 ± 0.40

0.022

Parameter	ECCP INF (n = 8)	EBCP INF (n = 8)	Cala INF (n = 8)	P-value
LVpdP
Baseline (mmHg)	91.0 ± 28.2	93.1 ± 26.8	82.0 ± 17.8	0.64
30-min reperfusion (%)	125.1 ± 43.3	131.6 ± 81.4	70.6 ± 31.2	0.081
90-min reperfusion (%)	84.9 ± 46.1	88.6 ± 55.0	56.3 ± 25.8	0.30
dLVP/dt_max
Baseline (mmHg/s)	2752 ± 831	2808 ± 856	2298 ± 506	0.35
30-min reperfusion (%)	130.6 ± 41.3	133.6 ± 68.0	89.1 ± 40.6	0.18
90-min reperfusion (%)	99.3 ± 40.6	103.3 ± 60.1	78.7 ± 40.5	0.56
dLVP/dt_min
Baseline (mmHg/s)	−2113 ± 716	−2182 ± 774	−1824 ± 357	0.51
30-min reperfusion (%)	127.4 ± 44.2	121.5 ± 64.8	78.6 ± 37.4	0.13
90-min reperfusion (%)	93.3 ± 41.7	88.5 ± 55.8	68.5 ± 35.1	0.52
Heart rate
Baseline (beats/min)	226.7 ± 33.3	207.6 ± 41.5	251.6 ± 48.1	0.13
30-min reperfusion (%)	84.6 ± 12.4	79.8 ± 23.2	82.3 ± 26.2	0.91
90-min reperfusion (%)	85.6 ± 15.0	72.9 ± 32.0	71.2 ± 32.5	0.54
Coronary blood flow
Baseline (ml/min)	3.8 ± 0.5	4.4 ± 0.9	4.4 ± 1.2	0.35
30-min reperfusion (%)	136.5 ± 52.9^*	147.2 ± 62.0^*	62.2 ± 41.4	0.008
90-min reperfusion (%)	75.6 ± 26.1	80.9 ± 37.9	53.8 ± 49.0	0.35
Oxygen consumption
Baseline [ml/(min 100 g)]	9.36 ± 1.29	9.36 ± 1.66	9.14 ± 5.70	0.99
10-min reperfusion (%)	123.0 ± 45.5	78.8 ± 30.6	72.9 ± 64.3	0.10
90-min reperfusion (%)	76.5 ± 30.9	91.3 ± 52.2	55.0 ± 54.3	0.32
Lactate production
Baseline [µmol/(ml min)]	0.52 ± 0.36	0.24 ± 0.51	0.04 ± 0.43	0.11
10-min reperfusion [µmol/(ml min)]	2.01 ± 0.88^*	1.32 ± 0.68	1.01 ± 0.56	0.032
90-min reperfusion [µmol/(ml min)]	1.43 ± 0.54^#	0.58 ± 0.71	1.04 ± 0.40	0.022

Table 2:

Open in new tab

Measurements in hearts with myocardial infarction

Parameter	ECCP INF (n = 8)	EBCP INF (n = 8)	Cala INF (n = 8)	P-value
LVpdP
Baseline (mmHg)	91.0 ± 28.2	93.1 ± 26.8	82.0 ± 17.8	0.64
30-min reperfusion (%)	125.1 ± 43.3	131.6 ± 81.4	70.6 ± 31.2	0.081
90-min reperfusion (%)	84.9 ± 46.1	88.6 ± 55.0	56.3 ± 25.8	0.30
dLVP/dt_max
Baseline (mmHg/s)	2752 ± 831	2808 ± 856	2298 ± 506	0.35
30-min reperfusion (%)	130.6 ± 41.3	133.6 ± 68.0	89.1 ± 40.6	0.18
90-min reperfusion (%)	99.3 ± 40.6	103.3 ± 60.1	78.7 ± 40.5	0.56
dLVP/dt_min
Baseline (mmHg/s)	−2113 ± 716	−2182 ± 774	−1824 ± 357	0.51
30-min reperfusion (%)	127.4 ± 44.2	121.5 ± 64.8	78.6 ± 37.4	0.13
90-min reperfusion (%)	93.3 ± 41.7	88.5 ± 55.8	68.5 ± 35.1	0.52
Heart rate
Baseline (beats/min)	226.7 ± 33.3	207.6 ± 41.5	251.6 ± 48.1	0.13
30-min reperfusion (%)	84.6 ± 12.4	79.8 ± 23.2	82.3 ± 26.2	0.91
90-min reperfusion (%)	85.6 ± 15.0	72.9 ± 32.0	71.2 ± 32.5	0.54
Coronary blood flow
Baseline (ml/min)	3.8 ± 0.5	4.4 ± 0.9	4.4 ± 1.2	0.35
30-min reperfusion (%)	136.5 ± 52.9^*	147.2 ± 62.0^*	62.2 ± 41.4	0.008
90-min reperfusion (%)	75.6 ± 26.1	80.9 ± 37.9	53.8 ± 49.0	0.35
Oxygen consumption
Baseline [ml/(min 100 g)]	9.36 ± 1.29	9.36 ± 1.66	9.14 ± 5.70	0.99
10-min reperfusion (%)	123.0 ± 45.5	78.8 ± 30.6	72.9 ± 64.3	0.10
90-min reperfusion (%)	76.5 ± 30.9	91.3 ± 52.2	55.0 ± 54.3	0.32
Lactate production
Baseline [µmol/(ml min)]	0.52 ± 0.36	0.24 ± 0.51	0.04 ± 0.43	0.11
10-min reperfusion [µmol/(ml min)]	2.01 ± 0.88^*	1.32 ± 0.68	1.01 ± 0.56	0.032
90-min reperfusion [µmol/(ml min)]	1.43 ± 0.54^#	0.58 ± 0.71	1.04 ± 0.40	0.022

Parameter	ECCP INF (n = 8)	EBCP INF (n = 8)	Cala INF (n = 8)	P-value
LVpdP
Baseline (mmHg)	91.0 ± 28.2	93.1 ± 26.8	82.0 ± 17.8	0.64
30-min reperfusion (%)	125.1 ± 43.3	131.6 ± 81.4	70.6 ± 31.2	0.081
90-min reperfusion (%)	84.9 ± 46.1	88.6 ± 55.0	56.3 ± 25.8	0.30
dLVP/dt_max
Baseline (mmHg/s)	2752 ± 831	2808 ± 856	2298 ± 506	0.35
30-min reperfusion (%)	130.6 ± 41.3	133.6 ± 68.0	89.1 ± 40.6	0.18
90-min reperfusion (%)	99.3 ± 40.6	103.3 ± 60.1	78.7 ± 40.5	0.56
dLVP/dt_min
Baseline (mmHg/s)	−2113 ± 716	−2182 ± 774	−1824 ± 357	0.51
30-min reperfusion (%)	127.4 ± 44.2	121.5 ± 64.8	78.6 ± 37.4	0.13
90-min reperfusion (%)	93.3 ± 41.7	88.5 ± 55.8	68.5 ± 35.1	0.52
Heart rate
Baseline (beats/min)	226.7 ± 33.3	207.6 ± 41.5	251.6 ± 48.1	0.13
30-min reperfusion (%)	84.6 ± 12.4	79.8 ± 23.2	82.3 ± 26.2	0.91
90-min reperfusion (%)	85.6 ± 15.0	72.9 ± 32.0	71.2 ± 32.5	0.54
Coronary blood flow
Baseline (ml/min)	3.8 ± 0.5	4.4 ± 0.9	4.4 ± 1.2	0.35
30-min reperfusion (%)	136.5 ± 52.9^*	147.2 ± 62.0^*	62.2 ± 41.4	0.008
90-min reperfusion (%)	75.6 ± 26.1	80.9 ± 37.9	53.8 ± 49.0	0.35
Oxygen consumption
Baseline [ml/(min 100 g)]	9.36 ± 1.29	9.36 ± 1.66	9.14 ± 5.70	0.99
10-min reperfusion (%)	123.0 ± 45.5	78.8 ± 30.6	72.9 ± 64.3	0.10
90-min reperfusion (%)	76.5 ± 30.9	91.3 ± 52.2	55.0 ± 54.3	0.32
Lactate production
Baseline [µmol/(ml min)]	0.52 ± 0.36	0.24 ± 0.51	0.04 ± 0.43	0.11
10-min reperfusion [µmol/(ml min)]	2.01 ± 0.88^*	1.32 ± 0.68	1.01 ± 0.56	0.032
90-min reperfusion [µmol/(ml min)]	1.43 ± 0.54^#	0.58 ± 0.71	1.04 ± 0.40	0.022

Values: mean ± standard deviation. % values: % of baseline.

P < 0.05 vs Cala,

P < 0.05 vs EBCP. dLVP/dt_max and dLVP/dt_min: velocity of contractility and relaxation over time; Cala: Calafiore blood cardioplegia; EBCP: esmolol blood cardioplegia; ECCP: esmolol crystalloid cardioplegia; INF: infarction; LVpdP: left ventricular peak developed pressure.

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