Table 1: Open in new tab Measurements in...

Parameter	ECCP NONINF (n = 6)	EBCP NONINF (n = 6)	Cala NONINF (n = 6)	P-value
LVpdP
Baseline (mmHg)	105.6 ± 27.1	101.4 ± 21.6	93.8 ± 26.8	0.72
30-min reperfusion (%)	157.5 ± 36.3^***	121.4 ± 18.6^*	80.9 ± 16.5	<0.001
90-min reperfusion (%)	100.4 ± 27.9^**	86.3 ± 11.2^*	56.9 ± 7.1	<0.001
dLVP/dt_max
Baseline (mmHg/s)	2928 ± 374	3013 ± 474	2764 ± 936	0.80
30-min reperfusion (%)	168.4 ± 26.8^***	137.6 ± 27.6	102.2 ± 18.5	0.001
90-min reperfusion (%)	128.0 ± 24.0^**	109.2 ± 25.9	84.6 ± 8.2	0.009
dLVP/dt_min
Baseline (mmHg/s)	−2283 ± 318	−2230 ± 544	−2050 ± 711	0.75
30-min reperfusion (%)	151.5 ± 29.3^**^,^#	112.7 ± 23.3	91.20 ± 20.1	0.002
90-min reperfusion (%)	113.8 ± 27.7^**^,^#	80.4 ± 17.4	73.3 ± 12.0	0.007
Heart rate
Baseline (beats/min)	206.7 ± 30.4	259.5 ± 32.1^§	230.4 ± 19.4	0.017
30-min reperfusion (%)	97.2 ± 12.0	86.0 ± 15.1	98.0 ± 15.8	0.30
90-min reperfusion (%)	107.6 ± 15.1^#	74.7 ± 25.0	99.8 ± 16.1	0.025
Coronary blood flow
Baseline (ml/min)	4.5 ± 0.9	4.3 ± 0.7	4.2 ± 0.9	0.87
30-min reperfusion (%)	228.4 ± 70.9^***^,^#	132.0 ± 68.3	65.1 ± 35.0	0.001
90-min reperfusion (%)	99.3 ± 29.2^*	71.4 ± 46.1	47.5 ± 19.1	0.052
Oxygen consumption
Baseline [ml/(min 100 g)]	10.92 ± 2.14	10.41 ± 1.61	10.44 ± 2.19	0.13
10-min reperfusion (%)	148.2 ± 58.8^*	126.5 ± 47.6	60.7 ± 24.6	0.013
90-min reperfusion (%)	99.5 ± 25.6	87.1 ± 48.7	55.2 ± 13.6	0.085
Lactate production
Baseline [µmol/(ml min)]	−0.01 ± 0.57	0.17 ± 0.31	0.02 ± 0.41	0.75
10-min reperfusion [µmol/(ml min)]	1.71 ± 1.68	1.87 ± 0.91	0.98 ± 0.57	0.38
90-min reperfusion [µmol/(ml min)]	0.67 ± 0.72	1.72 ± 0.93	0.97 ± 1.14	0.18

Parameter

ECCP NONINF (n = 6)

EBCP NONINF (n = 6)

Cala NONINF (n = 6)

P-value

LVpdP

Baseline (mmHg)

105.6 ± 27.1

101.4 ± 21.6

93.8 ± 26.8

0.72

30-min reperfusion (%)

157.5 ± 36.3^***

121.4 ± 18.6^*

80.9 ± 16.5

<0.001

90-min reperfusion (%)

100.4 ± 27.9^**

86.3 ± 11.2^*

56.9 ± 7.1

<0.001

dLVP/dt_max

Baseline (mmHg/s)

2928 ± 374

3013 ± 474

2764 ± 936

0.80

30-min reperfusion (%)

168.4 ± 26.8^***

137.6 ± 27.6

102.2 ± 18.5

0.001

90-min reperfusion (%)

128.0 ± 24.0^**

109.2 ± 25.9

84.6 ± 8.2

0.009

dLVP/dt_min

Baseline (mmHg/s)

−2283 ± 318

−2230 ± 544

−2050 ± 711

0.75

30-min reperfusion (%)

151.5 ± 29.3^**^,^#

112.7 ± 23.3

91.20 ± 20.1

0.002

90-min reperfusion (%)

113.8 ± 27.7^**^,^#

80.4 ± 17.4

73.3 ± 12.0

0.007

Heart rate

Baseline (beats/min)

206.7 ± 30.4

259.5 ± 32.1^§

230.4 ± 19.4

0.017

30-min reperfusion (%)

97.2 ± 12.0

86.0 ± 15.1

98.0 ± 15.8

0.30

90-min reperfusion (%)

107.6 ± 15.1^#

74.7 ± 25.0

99.8 ± 16.1

0.025

Coronary blood flow

Baseline (ml/min)

4.5 ± 0.9

4.3 ± 0.7

4.2 ± 0.9

0.87

30-min reperfusion (%)

228.4 ± 70.9^***^,^#

132.0 ± 68.3

65.1 ± 35.0

0.001

90-min reperfusion (%)

99.3 ± 29.2^*

71.4 ± 46.1

47.5 ± 19.1

0.052

Oxygen consumption

Baseline [ml/(min 100 g)]

10.92 ± 2.14

10.41 ± 1.61

10.44 ± 2.19

0.13

10-min reperfusion (%)

148.2 ± 58.8^*

126.5 ± 47.6

60.7 ± 24.6

0.013

90-min reperfusion (%)

99.5 ± 25.6

87.1 ± 48.7

55.2 ± 13.6

0.085

Lactate production

Baseline [µmol/(ml min)]

−0.01 ± 0.57

0.17 ± 0.31

0.02 ± 0.41

0.75

10-min reperfusion [µmol/(ml min)]

1.71 ± 1.68

1.87 ± 0.91

0.98 ± 0.57

0.38

90-min reperfusion [µmol/(ml min)]

0.67 ± 0.72

1.72 ± 0.93

0.97 ± 1.14

0.18

Parameter	ECCP NONINF (n = 6)	EBCP NONINF (n = 6)	Cala NONINF (n = 6)	P-value
LVpdP
Baseline (mmHg)	105.6 ± 27.1	101.4 ± 21.6	93.8 ± 26.8	0.72
30-min reperfusion (%)	157.5 ± 36.3^***	121.4 ± 18.6^*	80.9 ± 16.5	<0.001
90-min reperfusion (%)	100.4 ± 27.9^**	86.3 ± 11.2^*	56.9 ± 7.1	<0.001
dLVP/dt_max
Baseline (mmHg/s)	2928 ± 374	3013 ± 474	2764 ± 936	0.80
30-min reperfusion (%)	168.4 ± 26.8^***	137.6 ± 27.6	102.2 ± 18.5	0.001
90-min reperfusion (%)	128.0 ± 24.0^**	109.2 ± 25.9	84.6 ± 8.2	0.009
dLVP/dt_min
Baseline (mmHg/s)	−2283 ± 318	−2230 ± 544	−2050 ± 711	0.75
30-min reperfusion (%)	151.5 ± 29.3^**^,^#	112.7 ± 23.3	91.20 ± 20.1	0.002
90-min reperfusion (%)	113.8 ± 27.7^**^,^#	80.4 ± 17.4	73.3 ± 12.0	0.007
Heart rate
Baseline (beats/min)	206.7 ± 30.4	259.5 ± 32.1^§	230.4 ± 19.4	0.017
30-min reperfusion (%)	97.2 ± 12.0	86.0 ± 15.1	98.0 ± 15.8	0.30
90-min reperfusion (%)	107.6 ± 15.1^#	74.7 ± 25.0	99.8 ± 16.1	0.025
Coronary blood flow
Baseline (ml/min)	4.5 ± 0.9	4.3 ± 0.7	4.2 ± 0.9	0.87
30-min reperfusion (%)	228.4 ± 70.9^***^,^#	132.0 ± 68.3	65.1 ± 35.0	0.001
90-min reperfusion (%)	99.3 ± 29.2^*	71.4 ± 46.1	47.5 ± 19.1	0.052
Oxygen consumption
Baseline [ml/(min 100 g)]	10.92 ± 2.14	10.41 ± 1.61	10.44 ± 2.19	0.13
10-min reperfusion (%)	148.2 ± 58.8^*	126.5 ± 47.6	60.7 ± 24.6	0.013
90-min reperfusion (%)	99.5 ± 25.6	87.1 ± 48.7	55.2 ± 13.6	0.085
Lactate production
Baseline [µmol/(ml min)]	−0.01 ± 0.57	0.17 ± 0.31	0.02 ± 0.41	0.75
10-min reperfusion [µmol/(ml min)]	1.71 ± 1.68	1.87 ± 0.91	0.98 ± 0.57	0.38
90-min reperfusion [µmol/(ml min)]	0.67 ± 0.72	1.72 ± 0.93	0.97 ± 1.14	0.18

Table 1:

Open in new tab

Measurements in hearts without myocardial infarction

Parameter	ECCP NONINF (n = 6)	EBCP NONINF (n = 6)	Cala NONINF (n = 6)	P-value
LVpdP
Baseline (mmHg)	105.6 ± 27.1	101.4 ± 21.6	93.8 ± 26.8	0.72
30-min reperfusion (%)	157.5 ± 36.3^***	121.4 ± 18.6^*	80.9 ± 16.5	<0.001
90-min reperfusion (%)	100.4 ± 27.9^**	86.3 ± 11.2^*	56.9 ± 7.1	<0.001
dLVP/dt_max
Baseline (mmHg/s)	2928 ± 374	3013 ± 474	2764 ± 936	0.80
30-min reperfusion (%)	168.4 ± 26.8^***	137.6 ± 27.6	102.2 ± 18.5	0.001
90-min reperfusion (%)	128.0 ± 24.0^**	109.2 ± 25.9	84.6 ± 8.2	0.009
dLVP/dt_min
Baseline (mmHg/s)	−2283 ± 318	−2230 ± 544	−2050 ± 711	0.75
30-min reperfusion (%)	151.5 ± 29.3^**^,^#	112.7 ± 23.3	91.20 ± 20.1	0.002
90-min reperfusion (%)	113.8 ± 27.7^**^,^#	80.4 ± 17.4	73.3 ± 12.0	0.007
Heart rate
Baseline (beats/min)	206.7 ± 30.4	259.5 ± 32.1^§	230.4 ± 19.4	0.017
30-min reperfusion (%)	97.2 ± 12.0	86.0 ± 15.1	98.0 ± 15.8	0.30
90-min reperfusion (%)	107.6 ± 15.1^#	74.7 ± 25.0	99.8 ± 16.1	0.025
Coronary blood flow
Baseline (ml/min)	4.5 ± 0.9	4.3 ± 0.7	4.2 ± 0.9	0.87
30-min reperfusion (%)	228.4 ± 70.9^***^,^#	132.0 ± 68.3	65.1 ± 35.0	0.001
90-min reperfusion (%)	99.3 ± 29.2^*	71.4 ± 46.1	47.5 ± 19.1	0.052
Oxygen consumption
Baseline [ml/(min 100 g)]	10.92 ± 2.14	10.41 ± 1.61	10.44 ± 2.19	0.13
10-min reperfusion (%)	148.2 ± 58.8^*	126.5 ± 47.6	60.7 ± 24.6	0.013
90-min reperfusion (%)	99.5 ± 25.6	87.1 ± 48.7	55.2 ± 13.6	0.085
Lactate production
Baseline [µmol/(ml min)]	−0.01 ± 0.57	0.17 ± 0.31	0.02 ± 0.41	0.75
10-min reperfusion [µmol/(ml min)]	1.71 ± 1.68	1.87 ± 0.91	0.98 ± 0.57	0.38
90-min reperfusion [µmol/(ml min)]	0.67 ± 0.72	1.72 ± 0.93	0.97 ± 1.14	0.18

Parameter	ECCP NONINF (n = 6)	EBCP NONINF (n = 6)	Cala NONINF (n = 6)	P-value
LVpdP
Baseline (mmHg)	105.6 ± 27.1	101.4 ± 21.6	93.8 ± 26.8	0.72
30-min reperfusion (%)	157.5 ± 36.3^***	121.4 ± 18.6^*	80.9 ± 16.5	<0.001
90-min reperfusion (%)	100.4 ± 27.9^**	86.3 ± 11.2^*	56.9 ± 7.1	<0.001
dLVP/dt_max
Baseline (mmHg/s)	2928 ± 374	3013 ± 474	2764 ± 936	0.80
30-min reperfusion (%)	168.4 ± 26.8^***	137.6 ± 27.6	102.2 ± 18.5	0.001
90-min reperfusion (%)	128.0 ± 24.0^**	109.2 ± 25.9	84.6 ± 8.2	0.009
dLVP/dt_min
Baseline (mmHg/s)	−2283 ± 318	−2230 ± 544	−2050 ± 711	0.75
30-min reperfusion (%)	151.5 ± 29.3^**^,^#	112.7 ± 23.3	91.20 ± 20.1	0.002
90-min reperfusion (%)	113.8 ± 27.7^**^,^#	80.4 ± 17.4	73.3 ± 12.0	0.007
Heart rate
Baseline (beats/min)	206.7 ± 30.4	259.5 ± 32.1^§	230.4 ± 19.4	0.017
30-min reperfusion (%)	97.2 ± 12.0	86.0 ± 15.1	98.0 ± 15.8	0.30
90-min reperfusion (%)	107.6 ± 15.1^#	74.7 ± 25.0	99.8 ± 16.1	0.025
Coronary blood flow
Baseline (ml/min)	4.5 ± 0.9	4.3 ± 0.7	4.2 ± 0.9	0.87
30-min reperfusion (%)	228.4 ± 70.9^***^,^#	132.0 ± 68.3	65.1 ± 35.0	0.001
90-min reperfusion (%)	99.3 ± 29.2^*	71.4 ± 46.1	47.5 ± 19.1	0.052
Oxygen consumption
Baseline [ml/(min 100 g)]	10.92 ± 2.14	10.41 ± 1.61	10.44 ± 2.19	0.13
10-min reperfusion (%)	148.2 ± 58.8^*	126.5 ± 47.6	60.7 ± 24.6	0.013
90-min reperfusion (%)	99.5 ± 25.6	87.1 ± 48.7	55.2 ± 13.6	0.085
Lactate production
Baseline [µmol/(ml min)]	−0.01 ± 0.57	0.17 ± 0.31	0.02 ± 0.41	0.75
10-min reperfusion [µmol/(ml min)]	1.71 ± 1.68	1.87 ± 0.91	0.98 ± 0.57	0.38
90-min reperfusion [µmol/(ml min)]	0.67 ± 0.72	1.72 ± 0.93	0.97 ± 1.14	0.18

Values: mean ± standard deviation. % values: % of baseline.

P < 0.05 versus Cala,

P < 0.01 versus Cala,

***

P < 0.001 versus Cala,

P < 0.05 versus EBCP,

P < 0.05 versus ECCP.

Cala: Calafiore blood cardioplegia; dLVP/dt_max and dLVP/dt_min: velocity of contractility and relaxation over time; EBCP: esmolol blood cardioplegia; ECCP: esmolol crystalloid cardioplegia; LVpdP: left ventricular peak developed pressure; NONINF: noninfarction.

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