| Characteristic . | n (%) . | . | . |
|---|---|---|---|
| . | Pre-multiplex PCR ME Panel (n = 137) . | Post-multiplex PCR ME Panel (n = 69) . | P Value . |
| Age, median (IQR), years | 42 (32–62) | 41 (32–57) | .80 |
| Female | 87 (63.5) | 35 (50.7) | .07 |
| Race | .31 | ||
| White | 62 (45.3) | 39 (56.5) | |
| Black | 19 (13.9) | 9 (13.0) | |
| Asian | 8 (5.8) | 4 (5.8) | |
| Other | 18 (13.1) | 4 (5.8) | |
| Not specified | 30 (21.9) | 10 (14.5) | |
| Comorbidities | |||
| Cancera | 11 (8.0) | 8 (11.6) | .40 |
| Coronary artery disease | 14 (10.2) | 4 (5.8) | .43 |
| Diabetes mellitus | 19 (13.9) | 7 (10.1) | .43 |
| Hypertension | 34 (24.8) | 15 (21.7) | .62 |
| Use of immunosuppressive drugs | 13 (9.5) | 12 (17.4) | .10 |
| Clinical Presentation | |||
| Fever | 75 (54.7) | 37 (53.6) | .88 |
| Headache | 84 (61.3) | 49 (71.0) | .17 |
| Neck stiffness | 46 (33.6) | 16 (23.2) | .13 |
| Altered mental status | 46 (33.6) | 24 (34.8) | .86 |
| Seizure | 10 (7.3) | 2 (2.9) | .34 |
| Focal neurologic deficit | 9 (6.6) | 6 (8.7) | .58 |
| Characteristic . | n (%) . | . | . |
|---|---|---|---|
| . | Pre-multiplex PCR ME Panel (n = 137) . | Post-multiplex PCR ME Panel (n = 69) . | P Value . |
| Age, median (IQR), years | 42 (32–62) | 41 (32–57) | .80 |
| Female | 87 (63.5) | 35 (50.7) | .07 |
| Race | .31 | ||
| White | 62 (45.3) | 39 (56.5) | |
| Black | 19 (13.9) | 9 (13.0) | |
| Asian | 8 (5.8) | 4 (5.8) | |
| Other | 18 (13.1) | 4 (5.8) | |
| Not specified | 30 (21.9) | 10 (14.5) | |
| Comorbidities | |||
| Cancera | 11 (8.0) | 8 (11.6) | .40 |
| Coronary artery disease | 14 (10.2) | 4 (5.8) | .43 |
| Diabetes mellitus | 19 (13.9) | 7 (10.1) | .43 |
| Hypertension | 34 (24.8) | 15 (21.7) | .62 |
| Use of immunosuppressive drugs | 13 (9.5) | 12 (17.4) | .10 |
| Clinical Presentation | |||
| Fever | 75 (54.7) | 37 (53.6) | .88 |
| Headache | 84 (61.3) | 49 (71.0) | .17 |
| Neck stiffness | 46 (33.6) | 16 (23.2) | .13 |
| Altered mental status | 46 (33.6) | 24 (34.8) | .86 |
| Seizure | 10 (7.3) | 2 (2.9) | .34 |
| Focal neurologic deficit | 9 (6.6) | 6 (8.7) | .58 |
Abbreviations: ME, meningitis and encephalitis.
a Active cancer, defined by any of the following: diagnosed or receiving therapy within 6 months of presentation; recurrent or metastatic cancer.
| Characteristic . | n (%) . | . | . |
|---|---|---|---|
| . | Pre-multiplex PCR ME Panel (n = 137) . | Post-multiplex PCR ME Panel (n = 69) . | P Value . |
| Age, median (IQR), years | 42 (32–62) | 41 (32–57) | .80 |
| Female | 87 (63.5) | 35 (50.7) | .07 |
| Race | .31 | ||
| White | 62 (45.3) | 39 (56.5) | |
| Black | 19 (13.9) | 9 (13.0) | |
| Asian | 8 (5.8) | 4 (5.8) | |
| Other | 18 (13.1) | 4 (5.8) | |
| Not specified | 30 (21.9) | 10 (14.5) | |
| Comorbidities | |||
| Cancera | 11 (8.0) | 8 (11.6) | .40 |
| Coronary artery disease | 14 (10.2) | 4 (5.8) | .43 |
| Diabetes mellitus | 19 (13.9) | 7 (10.1) | .43 |
| Hypertension | 34 (24.8) | 15 (21.7) | .62 |
| Use of immunosuppressive drugs | 13 (9.5) | 12 (17.4) | .10 |
| Clinical Presentation | |||
| Fever | 75 (54.7) | 37 (53.6) | .88 |
| Headache | 84 (61.3) | 49 (71.0) | .17 |
| Neck stiffness | 46 (33.6) | 16 (23.2) | .13 |
| Altered mental status | 46 (33.6) | 24 (34.8) | .86 |
| Seizure | 10 (7.3) | 2 (2.9) | .34 |
| Focal neurologic deficit | 9 (6.6) | 6 (8.7) | .58 |
| Characteristic . | n (%) . | . | . |
|---|---|---|---|
| . | Pre-multiplex PCR ME Panel (n = 137) . | Post-multiplex PCR ME Panel (n = 69) . | P Value . |
| Age, median (IQR), years | 42 (32–62) | 41 (32–57) | .80 |
| Female | 87 (63.5) | 35 (50.7) | .07 |
| Race | .31 | ||
| White | 62 (45.3) | 39 (56.5) | |
| Black | 19 (13.9) | 9 (13.0) | |
| Asian | 8 (5.8) | 4 (5.8) | |
| Other | 18 (13.1) | 4 (5.8) | |
| Not specified | 30 (21.9) | 10 (14.5) | |
| Comorbidities | |||
| Cancera | 11 (8.0) | 8 (11.6) | .40 |
| Coronary artery disease | 14 (10.2) | 4 (5.8) | .43 |
| Diabetes mellitus | 19 (13.9) | 7 (10.1) | .43 |
| Hypertension | 34 (24.8) | 15 (21.7) | .62 |
| Use of immunosuppressive drugs | 13 (9.5) | 12 (17.4) | .10 |
| Clinical Presentation | |||
| Fever | 75 (54.7) | 37 (53.6) | .88 |
| Headache | 84 (61.3) | 49 (71.0) | .17 |
| Neck stiffness | 46 (33.6) | 16 (23.2) | .13 |
| Altered mental status | 46 (33.6) | 24 (34.8) | .86 |
| Seizure | 10 (7.3) | 2 (2.9) | .34 |
| Focal neurologic deficit | 9 (6.6) | 6 (8.7) | .58 |
Abbreviations: ME, meningitis and encephalitis.
a Active cancer, defined by any of the following: diagnosed or receiving therapy within 6 months of presentation; recurrent or metastatic cancer.
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