Sub-groups of women meeting symptom criteria for traumatic encephalopathy syndrome
| Clinical features and diagnostic criteria . | Mood (depression) (n = 708) (%) . | Behavioural (anger control) (n = 318) (%) . | Excessive gambling (n = 95) (%) . | Substance abuse/impulsivity (n = 93) (%) . | Suicidal (n = 133) (%) . | Headache (n = 1292) (%) . | Chronic pain (n = 960) (%) . | GAD (n = 278) (%) . | PTSD (n = 258) (%) . | Mood disorder and headache (n = 348) (%) . | Mood disorder and chronic pain (n = 284) (%) . | Mood disorder and anger control (n = 169) (%) . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Core clinical features | ||||||||||||
| Behavioural (anger control) | 23.9 | 100 | 8.4 | 28.0 | 30.1 | 12.5 | 12.5 | 25.5 | 20.5 | 29.0 | 26.8 | 100 |
| Mood (depression) | 100 | 53.1 | 27.4 | 43.0 | 65.4 | 26.9 | 29.6 | 58.3 | 48.1 | 100 | 100 | 100 |
| Behavioural or mood | 100 | 100 | 28.4 | 54.8 | 72.2 | 31.7 | 34.2 | 65.5 | 54.3 | 100 | 100 | 100 |
| Supportive clinical features | ||||||||||||
| Impulsivity | 5.6 | 8.2 | 1.1 | 100 | 12.0 | 2.9 | 3.1 | 6.1 | 7.4 | 5.2 | 6.3 | 8.9 |
| Anxiety | 73.6 | 75.5 | 49.5 | 62.4 | 76.7 | 47.4 | 50.9 | 100 | 100 | 80.7 | 80.3 | 86.4 |
| Apathy | 20.1 | 22.0 | 9.5 | 16.1 | 26.3 | 8.7 | 9.6 | 20.9 | 16.7 | 23.9 | 23.6 | 34.3 |
| Suicidality | 12.9 | 13.5 | 6.3 | 17.2 | 100 | 5.6 | 5.4 | 12.6 | 12.0 | 17.0 | 15.8 | 20.1 |
| Headache | 49.2 | 50.9 | 41.1 | 40.9 | 52.6 | 100 | 45.5 | 45.7 | 54.3 | 100 | 61.6 | 59.8 |
| One or more supportive criteria | 85.0 | 86.5 | 67.4 | 100 | 100 | 100 | 68.0 | 100 | 100 | 100 | 89.8 | 93.5 |
| Two or more supportive criteria | 52.7 | 55.0 | 28.4 | 81.7 | 86.5 | 49.4 | 34.0 | 60.1 | 65.9 | 82.8 | 62.7 | 71.6 |
| TES diagnostic criteria | ||||||||||||
| Behavioural and one or more supportive criteria | 22.3 | 86.5 | 8.4 | 28.0 | 30.1 | 12.5 | 11.4 | 25.5 | 20.5 | 29.0 | 25.0 | 93.5 |
| Behavioural and two or more supportive criteria | 17.1 | 55.0 | 5.3 | 25.8 | 30.1 | 10.2 | 8.4 | 18.7 | 17.4 | 25.9 | 21.1 | 71.6 |
| Mood and one or more supportive criteria | 85.0 | 49.7 | 24.2 | 43.0 | 65.4 | 26.9 | 26.6 | 58.3 | 48.1 | 100 | 89.8 | 93.5 |
| Mood and two or more supportive criteria | 52.7 | 38.1 | 14.7 | 40.9 | 60.9 | 22.3 | 18.5 | 40.6 | 39.5 | 82.8 | 62.7 | 71.6 |
| Behavioural or mood and one or more supportive criteria | 85.0 | 86.5 | 25.3 | 54.8 | 72.2 | 31.7 | 30.5 | 65.5 | 54.3 | 100 | 89.8 | 93.5 |
| Behavioural or mood and two or more supportive criteria | 52.7 | 55.0 | 14.7 | 50.5 | 67.7 | 25.5 | 20.7 | 44.2 | 43.4 | 82.8 | 62.7 | 71.6 |
| Clinical features and diagnostic criteria . | Mood (depression) (n = 708) (%) . | Behavioural (anger control) (n = 318) (%) . | Excessive gambling (n = 95) (%) . | Substance abuse/impulsivity (n = 93) (%) . | Suicidal (n = 133) (%) . | Headache (n = 1292) (%) . | Chronic pain (n = 960) (%) . | GAD (n = 278) (%) . | PTSD (n = 258) (%) . | Mood disorder and headache (n = 348) (%) . | Mood disorder and chronic pain (n = 284) (%) . | Mood disorder and anger control (n = 169) (%) . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Core clinical features | ||||||||||||
| Behavioural (anger control) | 23.9 | 100 | 8.4 | 28.0 | 30.1 | 12.5 | 12.5 | 25.5 | 20.5 | 29.0 | 26.8 | 100 |
| Mood (depression) | 100 | 53.1 | 27.4 | 43.0 | 65.4 | 26.9 | 29.6 | 58.3 | 48.1 | 100 | 100 | 100 |
| Behavioural or mood | 100 | 100 | 28.4 | 54.8 | 72.2 | 31.7 | 34.2 | 65.5 | 54.3 | 100 | 100 | 100 |
| Supportive clinical features | ||||||||||||
| Impulsivity | 5.6 | 8.2 | 1.1 | 100 | 12.0 | 2.9 | 3.1 | 6.1 | 7.4 | 5.2 | 6.3 | 8.9 |
| Anxiety | 73.6 | 75.5 | 49.5 | 62.4 | 76.7 | 47.4 | 50.9 | 100 | 100 | 80.7 | 80.3 | 86.4 |
| Apathy | 20.1 | 22.0 | 9.5 | 16.1 | 26.3 | 8.7 | 9.6 | 20.9 | 16.7 | 23.9 | 23.6 | 34.3 |
| Suicidality | 12.9 | 13.5 | 6.3 | 17.2 | 100 | 5.6 | 5.4 | 12.6 | 12.0 | 17.0 | 15.8 | 20.1 |
| Headache | 49.2 | 50.9 | 41.1 | 40.9 | 52.6 | 100 | 45.5 | 45.7 | 54.3 | 100 | 61.6 | 59.8 |
| One or more supportive criteria | 85.0 | 86.5 | 67.4 | 100 | 100 | 100 | 68.0 | 100 | 100 | 100 | 89.8 | 93.5 |
| Two or more supportive criteria | 52.7 | 55.0 | 28.4 | 81.7 | 86.5 | 49.4 | 34.0 | 60.1 | 65.9 | 82.8 | 62.7 | 71.6 |
| TES diagnostic criteria | ||||||||||||
| Behavioural and one or more supportive criteria | 22.3 | 86.5 | 8.4 | 28.0 | 30.1 | 12.5 | 11.4 | 25.5 | 20.5 | 29.0 | 25.0 | 93.5 |
| Behavioural and two or more supportive criteria | 17.1 | 55.0 | 5.3 | 25.8 | 30.1 | 10.2 | 8.4 | 18.7 | 17.4 | 25.9 | 21.1 | 71.6 |
| Mood and one or more supportive criteria | 85.0 | 49.7 | 24.2 | 43.0 | 65.4 | 26.9 | 26.6 | 58.3 | 48.1 | 100 | 89.8 | 93.5 |
| Mood and two or more supportive criteria | 52.7 | 38.1 | 14.7 | 40.9 | 60.9 | 22.3 | 18.5 | 40.6 | 39.5 | 82.8 | 62.7 | 71.6 |
| Behavioural or mood and one or more supportive criteria | 85.0 | 86.5 | 25.3 | 54.8 | 72.2 | 31.7 | 30.5 | 65.5 | 54.3 | 100 | 89.8 | 93.5 |
| Behavioural or mood and two or more supportive criteria | 52.7 | 55.0 | 14.7 | 50.5 | 67.7 | 25.5 | 20.7 | 44.2 | 43.4 | 82.8 | 62.7 | 71.6 |
GAD, generalized anxiety disorder; PTSD, posttraumatic stress disorder.
Sub-groups of women meeting symptom criteria for traumatic encephalopathy syndrome
| Clinical features and diagnostic criteria . | Mood (depression) (n = 708) (%) . | Behavioural (anger control) (n = 318) (%) . | Excessive gambling (n = 95) (%) . | Substance abuse/impulsivity (n = 93) (%) . | Suicidal (n = 133) (%) . | Headache (n = 1292) (%) . | Chronic pain (n = 960) (%) . | GAD (n = 278) (%) . | PTSD (n = 258) (%) . | Mood disorder and headache (n = 348) (%) . | Mood disorder and chronic pain (n = 284) (%) . | Mood disorder and anger control (n = 169) (%) . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Core clinical features | ||||||||||||
| Behavioural (anger control) | 23.9 | 100 | 8.4 | 28.0 | 30.1 | 12.5 | 12.5 | 25.5 | 20.5 | 29.0 | 26.8 | 100 |
| Mood (depression) | 100 | 53.1 | 27.4 | 43.0 | 65.4 | 26.9 | 29.6 | 58.3 | 48.1 | 100 | 100 | 100 |
| Behavioural or mood | 100 | 100 | 28.4 | 54.8 | 72.2 | 31.7 | 34.2 | 65.5 | 54.3 | 100 | 100 | 100 |
| Supportive clinical features | ||||||||||||
| Impulsivity | 5.6 | 8.2 | 1.1 | 100 | 12.0 | 2.9 | 3.1 | 6.1 | 7.4 | 5.2 | 6.3 | 8.9 |
| Anxiety | 73.6 | 75.5 | 49.5 | 62.4 | 76.7 | 47.4 | 50.9 | 100 | 100 | 80.7 | 80.3 | 86.4 |
| Apathy | 20.1 | 22.0 | 9.5 | 16.1 | 26.3 | 8.7 | 9.6 | 20.9 | 16.7 | 23.9 | 23.6 | 34.3 |
| Suicidality | 12.9 | 13.5 | 6.3 | 17.2 | 100 | 5.6 | 5.4 | 12.6 | 12.0 | 17.0 | 15.8 | 20.1 |
| Headache | 49.2 | 50.9 | 41.1 | 40.9 | 52.6 | 100 | 45.5 | 45.7 | 54.3 | 100 | 61.6 | 59.8 |
| One or more supportive criteria | 85.0 | 86.5 | 67.4 | 100 | 100 | 100 | 68.0 | 100 | 100 | 100 | 89.8 | 93.5 |
| Two or more supportive criteria | 52.7 | 55.0 | 28.4 | 81.7 | 86.5 | 49.4 | 34.0 | 60.1 | 65.9 | 82.8 | 62.7 | 71.6 |
| TES diagnostic criteria | ||||||||||||
| Behavioural and one or more supportive criteria | 22.3 | 86.5 | 8.4 | 28.0 | 30.1 | 12.5 | 11.4 | 25.5 | 20.5 | 29.0 | 25.0 | 93.5 |
| Behavioural and two or more supportive criteria | 17.1 | 55.0 | 5.3 | 25.8 | 30.1 | 10.2 | 8.4 | 18.7 | 17.4 | 25.9 | 21.1 | 71.6 |
| Mood and one or more supportive criteria | 85.0 | 49.7 | 24.2 | 43.0 | 65.4 | 26.9 | 26.6 | 58.3 | 48.1 | 100 | 89.8 | 93.5 |
| Mood and two or more supportive criteria | 52.7 | 38.1 | 14.7 | 40.9 | 60.9 | 22.3 | 18.5 | 40.6 | 39.5 | 82.8 | 62.7 | 71.6 |
| Behavioural or mood and one or more supportive criteria | 85.0 | 86.5 | 25.3 | 54.8 | 72.2 | 31.7 | 30.5 | 65.5 | 54.3 | 100 | 89.8 | 93.5 |
| Behavioural or mood and two or more supportive criteria | 52.7 | 55.0 | 14.7 | 50.5 | 67.7 | 25.5 | 20.7 | 44.2 | 43.4 | 82.8 | 62.7 | 71.6 |
| Clinical features and diagnostic criteria . | Mood (depression) (n = 708) (%) . | Behavioural (anger control) (n = 318) (%) . | Excessive gambling (n = 95) (%) . | Substance abuse/impulsivity (n = 93) (%) . | Suicidal (n = 133) (%) . | Headache (n = 1292) (%) . | Chronic pain (n = 960) (%) . | GAD (n = 278) (%) . | PTSD (n = 258) (%) . | Mood disorder and headache (n = 348) (%) . | Mood disorder and chronic pain (n = 284) (%) . | Mood disorder and anger control (n = 169) (%) . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Core clinical features | ||||||||||||
| Behavioural (anger control) | 23.9 | 100 | 8.4 | 28.0 | 30.1 | 12.5 | 12.5 | 25.5 | 20.5 | 29.0 | 26.8 | 100 |
| Mood (depression) | 100 | 53.1 | 27.4 | 43.0 | 65.4 | 26.9 | 29.6 | 58.3 | 48.1 | 100 | 100 | 100 |
| Behavioural or mood | 100 | 100 | 28.4 | 54.8 | 72.2 | 31.7 | 34.2 | 65.5 | 54.3 | 100 | 100 | 100 |
| Supportive clinical features | ||||||||||||
| Impulsivity | 5.6 | 8.2 | 1.1 | 100 | 12.0 | 2.9 | 3.1 | 6.1 | 7.4 | 5.2 | 6.3 | 8.9 |
| Anxiety | 73.6 | 75.5 | 49.5 | 62.4 | 76.7 | 47.4 | 50.9 | 100 | 100 | 80.7 | 80.3 | 86.4 |
| Apathy | 20.1 | 22.0 | 9.5 | 16.1 | 26.3 | 8.7 | 9.6 | 20.9 | 16.7 | 23.9 | 23.6 | 34.3 |
| Suicidality | 12.9 | 13.5 | 6.3 | 17.2 | 100 | 5.6 | 5.4 | 12.6 | 12.0 | 17.0 | 15.8 | 20.1 |
| Headache | 49.2 | 50.9 | 41.1 | 40.9 | 52.6 | 100 | 45.5 | 45.7 | 54.3 | 100 | 61.6 | 59.8 |
| One or more supportive criteria | 85.0 | 86.5 | 67.4 | 100 | 100 | 100 | 68.0 | 100 | 100 | 100 | 89.8 | 93.5 |
| Two or more supportive criteria | 52.7 | 55.0 | 28.4 | 81.7 | 86.5 | 49.4 | 34.0 | 60.1 | 65.9 | 82.8 | 62.7 | 71.6 |
| TES diagnostic criteria | ||||||||||||
| Behavioural and one or more supportive criteria | 22.3 | 86.5 | 8.4 | 28.0 | 30.1 | 12.5 | 11.4 | 25.5 | 20.5 | 29.0 | 25.0 | 93.5 |
| Behavioural and two or more supportive criteria | 17.1 | 55.0 | 5.3 | 25.8 | 30.1 | 10.2 | 8.4 | 18.7 | 17.4 | 25.9 | 21.1 | 71.6 |
| Mood and one or more supportive criteria | 85.0 | 49.7 | 24.2 | 43.0 | 65.4 | 26.9 | 26.6 | 58.3 | 48.1 | 100 | 89.8 | 93.5 |
| Mood and two or more supportive criteria | 52.7 | 38.1 | 14.7 | 40.9 | 60.9 | 22.3 | 18.5 | 40.6 | 39.5 | 82.8 | 62.7 | 71.6 |
| Behavioural or mood and one or more supportive criteria | 85.0 | 86.5 | 25.3 | 54.8 | 72.2 | 31.7 | 30.5 | 65.5 | 54.3 | 100 | 89.8 | 93.5 |
| Behavioural or mood and two or more supportive criteria | 52.7 | 55.0 | 14.7 | 50.5 | 67.7 | 25.5 | 20.7 | 44.2 | 43.4 | 82.8 | 62.7 | 71.6 |
GAD, generalized anxiety disorder; PTSD, posttraumatic stress disorder.
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