Fitted Values on the Day of Clinical Event (i.e., Discharge, Death, or Ventilation) From Outcome-Stratified Longitudinal Models Among Patients Within the Johns Hopkins COVID-19 Precision Medicine Analytics Platform Registry, Baltimore, Maryland, April 3, 2020, to June 25, 2020
| Biomarker . | Trajectory From Admission to Discharge . | Trajectory From Admission to Death . | Trajectory From Admission to Ventilation . | Trajectory From Ventilation to Discharge . | Trajectory From Ventilation to Death . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Fitted Valuea . | 95% CI . | Fitted Value . | 95% CI . | Fitted Value . | 95% CI . | Fitted Value . | 95% CI . | Fitted Value . | 95% CI . | |
| Log(CRP) | 0.8 | 0.7, 0.9 | 2.3 | 1.9, 2.7 | 2.5 | 2.3, 2.7 | 0.3 | 0, 0.6 | 2.5 | 2.1, 2.8 |
| Log(D-dimer) | −0.2 | −0.3, −0.1 | 1.3 | 1, 1.7 | 0.5 | 0.4, 0.7 | 0.6 | 0.3, 0.9 | 1.8 | 1.5, 2.1 |
| eGFR | 92 | 90.2, 93.8 | 51.7 | 44.8, 58.5 | 67.8 | 63.4, 72.3 | 75.9 | 70.1, 81.7 | 48.9 | 41.4, 56.4 |
| Log(ALC) | 0.4 | 0.4, 0.4 | −0.3 | −0.5, −0.1 | −0.2 | −0.3, −0.1 | 0.5 | 0.4, 0.6 | 0 | −0.1, 0.2 |
| Pulse | 81.6 | 80.7, 82.4 | 103.9 | 101.1, 106.7 | 91.3 | 89.2, 93.4 | 86.1 | 83.9, 88.3 | 100.7 | 97.9, 103.6 |
| Respiratory rate | 18.6 | 18.4, 18.8 | 25.9 | 25.1, 26.6 | 26.1 | 25.6, 26.6 | 19.2 | 18.4, 20.1 | 27.3 | 26.2, 28.4 |
| Spo2-to-Fio2 ratio | 460.5 | 456.6, 464.3 | 163.5 | 149.7, 177.3 | 238.6 | 228.8, 248.3 | 450.6 | 438.4, 462.8 | 157.1 | 141.4, 172.9 |
| Temperature | 36.7 | 36.7, 36.7 | 37.3 | 37.237.4 | 37.3 | 37.2, 37.3 | 36.5 | 36.4, 36.6 | 37 | 36.8, 37.1 |
| Biomarker . | Trajectory From Admission to Discharge . | Trajectory From Admission to Death . | Trajectory From Admission to Ventilation . | Trajectory From Ventilation to Discharge . | Trajectory From Ventilation to Death . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Fitted Valuea . | 95% CI . | Fitted Value . | 95% CI . | Fitted Value . | 95% CI . | Fitted Value . | 95% CI . | Fitted Value . | 95% CI . | |
| Log(CRP) | 0.8 | 0.7, 0.9 | 2.3 | 1.9, 2.7 | 2.5 | 2.3, 2.7 | 0.3 | 0, 0.6 | 2.5 | 2.1, 2.8 |
| Log(D-dimer) | −0.2 | −0.3, −0.1 | 1.3 | 1, 1.7 | 0.5 | 0.4, 0.7 | 0.6 | 0.3, 0.9 | 1.8 | 1.5, 2.1 |
| eGFR | 92 | 90.2, 93.8 | 51.7 | 44.8, 58.5 | 67.8 | 63.4, 72.3 | 75.9 | 70.1, 81.7 | 48.9 | 41.4, 56.4 |
| Log(ALC) | 0.4 | 0.4, 0.4 | −0.3 | −0.5, −0.1 | −0.2 | −0.3, −0.1 | 0.5 | 0.4, 0.6 | 0 | −0.1, 0.2 |
| Pulse | 81.6 | 80.7, 82.4 | 103.9 | 101.1, 106.7 | 91.3 | 89.2, 93.4 | 86.1 | 83.9, 88.3 | 100.7 | 97.9, 103.6 |
| Respiratory rate | 18.6 | 18.4, 18.8 | 25.9 | 25.1, 26.6 | 26.1 | 25.6, 26.6 | 19.2 | 18.4, 20.1 | 27.3 | 26.2, 28.4 |
| Spo2-to-Fio2 ratio | 460.5 | 456.6, 464.3 | 163.5 | 149.7, 177.3 | 238.6 | 228.8, 248.3 | 450.6 | 438.4, 462.8 | 157.1 | 141.4, 172.9 |
| Temperature | 36.7 | 36.7, 36.7 | 37.3 | 37.237.4 | 37.3 | 37.2, 37.3 | 36.5 | 36.4, 36.6 | 37 | 36.8, 37.1 |
Abbreviations: ALC, absolute lymphocyte count; CI, confidence interval; COVID-19, coronavirus disease 2019; CRP, C-reactive protein; eGFR, estimated glomerular filtration rate; Fio2, fraction of inspired oxygen; Spo2, oxygen saturation.
a Fitted values calculated from 16 outcome-stratified longitudinal models (for each biomarker pre- and postventilation). In each column, the fitted value represents the population-average value on the day of the final event in each trajectory (i.e., day 0 in each model). For example, patients in our study population who were admitted and discharged without requiring mechanical ventilatory support were discharged with an average log(CRP) value of 0.8 (95% CI: 0.7, 0.9).
Fitted Values on the Day of Clinical Event (i.e., Discharge, Death, or Ventilation) From Outcome-Stratified Longitudinal Models Among Patients Within the Johns Hopkins COVID-19 Precision Medicine Analytics Platform Registry, Baltimore, Maryland, April 3, 2020, to June 25, 2020
| Biomarker . | Trajectory From Admission to Discharge . | Trajectory From Admission to Death . | Trajectory From Admission to Ventilation . | Trajectory From Ventilation to Discharge . | Trajectory From Ventilation to Death . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Fitted Valuea . | 95% CI . | Fitted Value . | 95% CI . | Fitted Value . | 95% CI . | Fitted Value . | 95% CI . | Fitted Value . | 95% CI . | |
| Log(CRP) | 0.8 | 0.7, 0.9 | 2.3 | 1.9, 2.7 | 2.5 | 2.3, 2.7 | 0.3 | 0, 0.6 | 2.5 | 2.1, 2.8 |
| Log(D-dimer) | −0.2 | −0.3, −0.1 | 1.3 | 1, 1.7 | 0.5 | 0.4, 0.7 | 0.6 | 0.3, 0.9 | 1.8 | 1.5, 2.1 |
| eGFR | 92 | 90.2, 93.8 | 51.7 | 44.8, 58.5 | 67.8 | 63.4, 72.3 | 75.9 | 70.1, 81.7 | 48.9 | 41.4, 56.4 |
| Log(ALC) | 0.4 | 0.4, 0.4 | −0.3 | −0.5, −0.1 | −0.2 | −0.3, −0.1 | 0.5 | 0.4, 0.6 | 0 | −0.1, 0.2 |
| Pulse | 81.6 | 80.7, 82.4 | 103.9 | 101.1, 106.7 | 91.3 | 89.2, 93.4 | 86.1 | 83.9, 88.3 | 100.7 | 97.9, 103.6 |
| Respiratory rate | 18.6 | 18.4, 18.8 | 25.9 | 25.1, 26.6 | 26.1 | 25.6, 26.6 | 19.2 | 18.4, 20.1 | 27.3 | 26.2, 28.4 |
| Spo2-to-Fio2 ratio | 460.5 | 456.6, 464.3 | 163.5 | 149.7, 177.3 | 238.6 | 228.8, 248.3 | 450.6 | 438.4, 462.8 | 157.1 | 141.4, 172.9 |
| Temperature | 36.7 | 36.7, 36.7 | 37.3 | 37.237.4 | 37.3 | 37.2, 37.3 | 36.5 | 36.4, 36.6 | 37 | 36.8, 37.1 |
| Biomarker . | Trajectory From Admission to Discharge . | Trajectory From Admission to Death . | Trajectory From Admission to Ventilation . | Trajectory From Ventilation to Discharge . | Trajectory From Ventilation to Death . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Fitted Valuea . | 95% CI . | Fitted Value . | 95% CI . | Fitted Value . | 95% CI . | Fitted Value . | 95% CI . | Fitted Value . | 95% CI . | |
| Log(CRP) | 0.8 | 0.7, 0.9 | 2.3 | 1.9, 2.7 | 2.5 | 2.3, 2.7 | 0.3 | 0, 0.6 | 2.5 | 2.1, 2.8 |
| Log(D-dimer) | −0.2 | −0.3, −0.1 | 1.3 | 1, 1.7 | 0.5 | 0.4, 0.7 | 0.6 | 0.3, 0.9 | 1.8 | 1.5, 2.1 |
| eGFR | 92 | 90.2, 93.8 | 51.7 | 44.8, 58.5 | 67.8 | 63.4, 72.3 | 75.9 | 70.1, 81.7 | 48.9 | 41.4, 56.4 |
| Log(ALC) | 0.4 | 0.4, 0.4 | −0.3 | −0.5, −0.1 | −0.2 | −0.3, −0.1 | 0.5 | 0.4, 0.6 | 0 | −0.1, 0.2 |
| Pulse | 81.6 | 80.7, 82.4 | 103.9 | 101.1, 106.7 | 91.3 | 89.2, 93.4 | 86.1 | 83.9, 88.3 | 100.7 | 97.9, 103.6 |
| Respiratory rate | 18.6 | 18.4, 18.8 | 25.9 | 25.1, 26.6 | 26.1 | 25.6, 26.6 | 19.2 | 18.4, 20.1 | 27.3 | 26.2, 28.4 |
| Spo2-to-Fio2 ratio | 460.5 | 456.6, 464.3 | 163.5 | 149.7, 177.3 | 238.6 | 228.8, 248.3 | 450.6 | 438.4, 462.8 | 157.1 | 141.4, 172.9 |
| Temperature | 36.7 | 36.7, 36.7 | 37.3 | 37.237.4 | 37.3 | 37.2, 37.3 | 36.5 | 36.4, 36.6 | 37 | 36.8, 37.1 |
Abbreviations: ALC, absolute lymphocyte count; CI, confidence interval; COVID-19, coronavirus disease 2019; CRP, C-reactive protein; eGFR, estimated glomerular filtration rate; Fio2, fraction of inspired oxygen; Spo2, oxygen saturation.
a Fitted values calculated from 16 outcome-stratified longitudinal models (for each biomarker pre- and postventilation). In each column, the fitted value represents the population-average value on the day of the final event in each trajectory (i.e., day 0 in each model). For example, patients in our study population who were admitted and discharged without requiring mechanical ventilatory support were discharged with an average log(CRP) value of 0.8 (95% CI: 0.7, 0.9).
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