Table 6. Open in new tab Bone Marrow MN...

Table 6.

Bone Marrow MN Frequency in Sprague-Dawley Rats Treated with NNK by Nose-Only Inhalation for 14 days

Sampling Time	Group	%RETs	%MN-NCEs	%MN-RETs
Day 15	Sham	40.99 ± 10.18^a	0.19 ± 0.15^a	0.74 ± 0.27^a
	Vehicle	37.59 ± 4.20^a	0.23 ± 0.06^a	0.87 ± 0.47^a
	Low	44.53 ± 7.70	0.29 ± 0.17	0.71 ± 0.32
	Mid	37.34 ± 10.53	0.16 ± 0.09	0.59 ± 0.23
	Mid High	38.78 ± 8.92	0.22 ± 0.17	0.68 ± 0.32
	High	35.89 ± 10.41	0.29 ± 0.22	0.66 ± 0.38
ANOVA		p = .13	p = .19	p = .70

Sampling Time	Group	%RETs	%MN-NCEs	%MN-RETs
Day 15	Sham	40.99 ± 10.18^a	0.19 ± 0.15^a	0.74 ± 0.27^a
	Vehicle	37.59 ± 4.20^a	0.23 ± 0.06^a	0.87 ± 0.47^a
	Low	44.53 ± 7.70	0.29 ± 0.17	0.71 ± 0.32
	Mid	37.34 ± 10.53	0.16 ± 0.09	0.59 ± 0.23
	Mid High	38.78 ± 8.92	0.22 ± 0.17	0.68 ± 0.32
	High	35.89 ± 10.41	0.29 ± 0.22	0.66 ± 0.38
ANOVA		p = .13	p = .19	p = .70

%RETs, percent reticulocytes (among total erythrocytes); %MN-NCE, percent micronucleated normochromatic (mature) erythrocytes; %MN-RETs, percent micronucleated reticulocytes.

The data are presented as the mean ± SD for 12 rats (6 males and 6 females), except where noted.

n = 11.

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