| Clinical Criteria for Li-Fraumeni Syndrome . | . |
|---|---|
| Classical criteria (all must apply) | A patient with a sarcoma diagnosed before age 45 yr |
| A first-degree relative with any cancer before age 45 yr | |
| A first- or second-degree relative with any cancer before age 45 yr or a sarcoma at any age | |
| Revised Chompret criteria (only one must apply) | Familial presentation: Proband with an LFS spectrum tumora prior to age 46 yr and at least 1 first- or second-degree relative with an LFS tumor (except breast cancer, if the proband has breast cancer) before the age of 56 yr or with multiple tumors |
| Multiple tumors: Proband with multiple malignancies (except 2 breast cancers), of which at least 2 belong to the LFS spectrum, before the age of 46 yr | |
| Rare tumors: Patients with ACC, choroid plexus carcinoma, or embryonal anaplastic subtype rhabdomyosarcoma independent of family history | |
| Early-onset breast cancer: Patients with breast cancer before the age of 31 yr |
| Clinical Criteria for Li-Fraumeni Syndrome . | . |
|---|---|
| Classical criteria (all must apply) | A patient with a sarcoma diagnosed before age 45 yr |
| A first-degree relative with any cancer before age 45 yr | |
| A first- or second-degree relative with any cancer before age 45 yr or a sarcoma at any age | |
| Revised Chompret criteria (only one must apply) | Familial presentation: Proband with an LFS spectrum tumora prior to age 46 yr and at least 1 first- or second-degree relative with an LFS tumor (except breast cancer, if the proband has breast cancer) before the age of 56 yr or with multiple tumors |
| Multiple tumors: Proband with multiple malignancies (except 2 breast cancers), of which at least 2 belong to the LFS spectrum, before the age of 46 yr | |
| Rare tumors: Patients with ACC, choroid plexus carcinoma, or embryonal anaplastic subtype rhabdomyosarcoma independent of family history | |
| Early-onset breast cancer: Patients with breast cancer before the age of 31 yr |
Abbreviations: ACC, adrenocortical carcinoma; LFS, Li-Fraumeni syndrome.
aLFS spectrum tumors: premenopausal breast cancer, soft-tissue sarcoma, brain tumor, and adrenocortical carcinoma.
| Clinical Criteria for Li-Fraumeni Syndrome . | . |
|---|---|
| Classical criteria (all must apply) | A patient with a sarcoma diagnosed before age 45 yr |
| A first-degree relative with any cancer before age 45 yr | |
| A first- or second-degree relative with any cancer before age 45 yr or a sarcoma at any age | |
| Revised Chompret criteria (only one must apply) | Familial presentation: Proband with an LFS spectrum tumora prior to age 46 yr and at least 1 first- or second-degree relative with an LFS tumor (except breast cancer, if the proband has breast cancer) before the age of 56 yr or with multiple tumors |
| Multiple tumors: Proband with multiple malignancies (except 2 breast cancers), of which at least 2 belong to the LFS spectrum, before the age of 46 yr | |
| Rare tumors: Patients with ACC, choroid plexus carcinoma, or embryonal anaplastic subtype rhabdomyosarcoma independent of family history | |
| Early-onset breast cancer: Patients with breast cancer before the age of 31 yr |
| Clinical Criteria for Li-Fraumeni Syndrome . | . |
|---|---|
| Classical criteria (all must apply) | A patient with a sarcoma diagnosed before age 45 yr |
| A first-degree relative with any cancer before age 45 yr | |
| A first- or second-degree relative with any cancer before age 45 yr or a sarcoma at any age | |
| Revised Chompret criteria (only one must apply) | Familial presentation: Proband with an LFS spectrum tumora prior to age 46 yr and at least 1 first- or second-degree relative with an LFS tumor (except breast cancer, if the proband has breast cancer) before the age of 56 yr or with multiple tumors |
| Multiple tumors: Proband with multiple malignancies (except 2 breast cancers), of which at least 2 belong to the LFS spectrum, before the age of 46 yr | |
| Rare tumors: Patients with ACC, choroid plexus carcinoma, or embryonal anaplastic subtype rhabdomyosarcoma independent of family history | |
| Early-onset breast cancer: Patients with breast cancer before the age of 31 yr |
Abbreviations: ACC, adrenocortical carcinoma; LFS, Li-Fraumeni syndrome.
aLFS spectrum tumors: premenopausal breast cancer, soft-tissue sarcoma, brain tumor, and adrenocortical carcinoma.
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