Multivariate-adjusted hazard ratios and 95% confidence intervals for cardiovascular outcomes associated with baseline metabolic and obese status.
| . | MHN . | MUN . | MHO . | MUO . |
|---|---|---|---|---|
| Combined CVD | ||||
| n/N | 114/3232 | 46/860 | 55/1255 | 129/2125 |
| Model 1 | 1.00 (ref) | 1.27 (0.90–1.80) | 1.50 (1.09–2.08) | 1.72 (1.33–2.22) |
| Model 2 | 1.00 (ref) | 1.25 (0.89–1.77) | 1.55 (1.12–2.14) | 1.77 (1.37–2.29) |
| Model 3 | 1.00 (ref) | 1.16 (0.82–1.65) | 1.48 (1.07–2.06) | 1.58 (1.21–2.07) |
| Fatal CVD | ||||
| n/N | 26/3232 | 14/860 | 8/1255 | 24/2125 |
| Model 1 | 1.00 (ref) | 1.33 (0.69–2.58) | 1.00 (0.45–2.22) | 1.27 (0.73–2.23) |
| Model 2 | 1.00 (ref) | 1.30 (0.67–2.52) | 1.01 (0.46–2.26) | 1.29 (0.73–2.27) |
| Model 3 | 1.00 (ref) | 1.18 (0.60–2.32) | 0.98 (0.44–2.18) | 1.11 (0.61–2.02) |
| Stroke | ||||
| n/N | 88/3232 | 34/860 | 34/1255 | 86/2125 |
| Model 1 | 1.00 (ref) | 1.27 (0.85–1.90) | 1.24 (0.83–1.85) | 1.48 (1.10–2.01) |
| Model 2 | 1.00 (ref) | 1.25 (0.84–1.87) | 1.29 (0.87–1.93) | 1.54 (1.13–2.09) |
| Model 3 | 1.00 (ref) | 1.13 (0.75–1.69) | 1.23 (0.82–1.84) | 1.32 (0.96–1.83) |
| CHD | ||||
| n/N | 30/3232 | 13/860 | 23/1255 | 47/2125 |
| Model 1 | 1.00 (ref) | 1.30 (0.67–2.52) | 2.55 (1.46–4.45) | 2.46 (1.53–3.96) |
| Model 2 | 1.00 (ref) | 1.26 (0.65–2.44) | 2.56 (1.47–4.48) | 2.48 (1.54–3.99) |
| Model 3 | 1.00 (ref) | 1.28 (0.65–2.50) | 2.56 (1.45–4.49) | 2.54 (1.54–4.20) |
| . | MHN . | MUN . | MHO . | MUO . |
|---|---|---|---|---|
| Combined CVD | ||||
| n/N | 114/3232 | 46/860 | 55/1255 | 129/2125 |
| Model 1 | 1.00 (ref) | 1.27 (0.90–1.80) | 1.50 (1.09–2.08) | 1.72 (1.33–2.22) |
| Model 2 | 1.00 (ref) | 1.25 (0.89–1.77) | 1.55 (1.12–2.14) | 1.77 (1.37–2.29) |
| Model 3 | 1.00 (ref) | 1.16 (0.82–1.65) | 1.48 (1.07–2.06) | 1.58 (1.21–2.07) |
| Fatal CVD | ||||
| n/N | 26/3232 | 14/860 | 8/1255 | 24/2125 |
| Model 1 | 1.00 (ref) | 1.33 (0.69–2.58) | 1.00 (0.45–2.22) | 1.27 (0.73–2.23) |
| Model 2 | 1.00 (ref) | 1.30 (0.67–2.52) | 1.01 (0.46–2.26) | 1.29 (0.73–2.27) |
| Model 3 | 1.00 (ref) | 1.18 (0.60–2.32) | 0.98 (0.44–2.18) | 1.11 (0.61–2.02) |
| Stroke | ||||
| n/N | 88/3232 | 34/860 | 34/1255 | 86/2125 |
| Model 1 | 1.00 (ref) | 1.27 (0.85–1.90) | 1.24 (0.83–1.85) | 1.48 (1.10–2.01) |
| Model 2 | 1.00 (ref) | 1.25 (0.84–1.87) | 1.29 (0.87–1.93) | 1.54 (1.13–2.09) |
| Model 3 | 1.00 (ref) | 1.13 (0.75–1.69) | 1.23 (0.82–1.84) | 1.32 (0.96–1.83) |
| CHD | ||||
| n/N | 30/3232 | 13/860 | 23/1255 | 47/2125 |
| Model 1 | 1.00 (ref) | 1.30 (0.67–2.52) | 2.55 (1.46–4.45) | 2.46 (1.53–3.96) |
| Model 2 | 1.00 (ref) | 1.26 (0.65–2.44) | 2.56 (1.47–4.48) | 2.48 (1.54–3.99) |
| Model 3 | 1.00 (ref) | 1.28 (0.65–2.50) | 2.56 (1.45–4.49) | 2.54 (1.54–4.20) |
CHD: coronary heart disease; CVD: cardiovascular disease; MHN: metabolically healthy non-obesity; MHO: metabolically healthy obesity; MUN: metabolically unhealthy non-obesity; MUO: metabolically unhealthy obesity.
Model 1: adjusted for age, sex and ethnicity. Model 2: adjusted for factors in model 1 and current smoking, current drinking, education, family income, regular exercise, and family history of cardiovascular disease. Model 3: adjusted for factors in model 2 and estimated glomerular filtration rate, low-density lipoprotein cholesterol, uric acid, statin use and aspirin use.
Multivariate-adjusted hazard ratios and 95% confidence intervals for cardiovascular outcomes associated with baseline metabolic and obese status.
| . | MHN . | MUN . | MHO . | MUO . |
|---|---|---|---|---|
| Combined CVD | ||||
| n/N | 114/3232 | 46/860 | 55/1255 | 129/2125 |
| Model 1 | 1.00 (ref) | 1.27 (0.90–1.80) | 1.50 (1.09–2.08) | 1.72 (1.33–2.22) |
| Model 2 | 1.00 (ref) | 1.25 (0.89–1.77) | 1.55 (1.12–2.14) | 1.77 (1.37–2.29) |
| Model 3 | 1.00 (ref) | 1.16 (0.82–1.65) | 1.48 (1.07–2.06) | 1.58 (1.21–2.07) |
| Fatal CVD | ||||
| n/N | 26/3232 | 14/860 | 8/1255 | 24/2125 |
| Model 1 | 1.00 (ref) | 1.33 (0.69–2.58) | 1.00 (0.45–2.22) | 1.27 (0.73–2.23) |
| Model 2 | 1.00 (ref) | 1.30 (0.67–2.52) | 1.01 (0.46–2.26) | 1.29 (0.73–2.27) |
| Model 3 | 1.00 (ref) | 1.18 (0.60–2.32) | 0.98 (0.44–2.18) | 1.11 (0.61–2.02) |
| Stroke | ||||
| n/N | 88/3232 | 34/860 | 34/1255 | 86/2125 |
| Model 1 | 1.00 (ref) | 1.27 (0.85–1.90) | 1.24 (0.83–1.85) | 1.48 (1.10–2.01) |
| Model 2 | 1.00 (ref) | 1.25 (0.84–1.87) | 1.29 (0.87–1.93) | 1.54 (1.13–2.09) |
| Model 3 | 1.00 (ref) | 1.13 (0.75–1.69) | 1.23 (0.82–1.84) | 1.32 (0.96–1.83) |
| CHD | ||||
| n/N | 30/3232 | 13/860 | 23/1255 | 47/2125 |
| Model 1 | 1.00 (ref) | 1.30 (0.67–2.52) | 2.55 (1.46–4.45) | 2.46 (1.53–3.96) |
| Model 2 | 1.00 (ref) | 1.26 (0.65–2.44) | 2.56 (1.47–4.48) | 2.48 (1.54–3.99) |
| Model 3 | 1.00 (ref) | 1.28 (0.65–2.50) | 2.56 (1.45–4.49) | 2.54 (1.54–4.20) |
| . | MHN . | MUN . | MHO . | MUO . |
|---|---|---|---|---|
| Combined CVD | ||||
| n/N | 114/3232 | 46/860 | 55/1255 | 129/2125 |
| Model 1 | 1.00 (ref) | 1.27 (0.90–1.80) | 1.50 (1.09–2.08) | 1.72 (1.33–2.22) |
| Model 2 | 1.00 (ref) | 1.25 (0.89–1.77) | 1.55 (1.12–2.14) | 1.77 (1.37–2.29) |
| Model 3 | 1.00 (ref) | 1.16 (0.82–1.65) | 1.48 (1.07–2.06) | 1.58 (1.21–2.07) |
| Fatal CVD | ||||
| n/N | 26/3232 | 14/860 | 8/1255 | 24/2125 |
| Model 1 | 1.00 (ref) | 1.33 (0.69–2.58) | 1.00 (0.45–2.22) | 1.27 (0.73–2.23) |
| Model 2 | 1.00 (ref) | 1.30 (0.67–2.52) | 1.01 (0.46–2.26) | 1.29 (0.73–2.27) |
| Model 3 | 1.00 (ref) | 1.18 (0.60–2.32) | 0.98 (0.44–2.18) | 1.11 (0.61–2.02) |
| Stroke | ||||
| n/N | 88/3232 | 34/860 | 34/1255 | 86/2125 |
| Model 1 | 1.00 (ref) | 1.27 (0.85–1.90) | 1.24 (0.83–1.85) | 1.48 (1.10–2.01) |
| Model 2 | 1.00 (ref) | 1.25 (0.84–1.87) | 1.29 (0.87–1.93) | 1.54 (1.13–2.09) |
| Model 3 | 1.00 (ref) | 1.13 (0.75–1.69) | 1.23 (0.82–1.84) | 1.32 (0.96–1.83) |
| CHD | ||||
| n/N | 30/3232 | 13/860 | 23/1255 | 47/2125 |
| Model 1 | 1.00 (ref) | 1.30 (0.67–2.52) | 2.55 (1.46–4.45) | 2.46 (1.53–3.96) |
| Model 2 | 1.00 (ref) | 1.26 (0.65–2.44) | 2.56 (1.47–4.48) | 2.48 (1.54–3.99) |
| Model 3 | 1.00 (ref) | 1.28 (0.65–2.50) | 2.56 (1.45–4.49) | 2.54 (1.54–4.20) |
CHD: coronary heart disease; CVD: cardiovascular disease; MHN: metabolically healthy non-obesity; MHO: metabolically healthy obesity; MUN: metabolically unhealthy non-obesity; MUO: metabolically unhealthy obesity.
Model 1: adjusted for age, sex and ethnicity. Model 2: adjusted for factors in model 1 and current smoking, current drinking, education, family income, regular exercise, and family history of cardiovascular disease. Model 3: adjusted for factors in model 2 and estimated glomerular filtration rate, low-density lipoprotein cholesterol, uric acid, statin use and aspirin use.
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