| . | Placebo . | REB + HBB . |
|---|---|---|
| Karolinska sleepiness scale | 5 ± 2 | 5 ± 2 |
| AHI (no. of events h−1 sleep) | 3 ± 4 | 3 ± 4 |
| Sleep efficiency (%) | 71 ± 15 | 75 ± 13 |
| N1 (% total sleep time) | 16 ± 8 | 21 ± 12 |
| N2 (% total sleep time) | 56 ± 10 | 65 ± 8* |
| Slow wave sleep (% total sleep time) | 13 ± 7 | 13 ± 9 |
| REM sleep (% total sleep time) | 15 ± 7 | 1 ± 1* |
| Arousal index (no. of arousals h−1 sleep) | 23 ± 10 | 26 ± 15 |
| Arousal duration (s) | 13 ± 3 | 14 ± 2 |
| Nadir SpO2 during sleep (%) | 92 ± 2 | 91 ± 3 |
| . | Placebo . | REB + HBB . |
|---|---|---|
| Karolinska sleepiness scale | 5 ± 2 | 5 ± 2 |
| AHI (no. of events h−1 sleep) | 3 ± 4 | 3 ± 4 |
| Sleep efficiency (%) | 71 ± 15 | 75 ± 13 |
| N1 (% total sleep time) | 16 ± 8 | 21 ± 12 |
| N2 (% total sleep time) | 56 ± 10 | 65 ± 8* |
| Slow wave sleep (% total sleep time) | 13 ± 7 | 13 ± 9 |
| REM sleep (% total sleep time) | 15 ± 7 | 1 ± 1* |
| Arousal index (no. of arousals h−1 sleep) | 23 ± 10 | 26 ± 15 |
| Arousal duration (s) | 13 ± 3 | 14 ± 2 |
| Nadir SpO2 during sleep (%) | 92 ± 2 | 91 ± 3 |
Polysomnography parameters (n = 10) except for rapid eye movement (REM) sleep (n = 3). AHI, apnea/hypopnea index, SpO2, arterial oxygen saturation estimated via pulse oximetry, REB, reboxetine and HBB, hyoscine butylbromide. Values are mean ± SD.
*Significant difference compared with placebo.
| . | Placebo . | REB + HBB . |
|---|---|---|
| Karolinska sleepiness scale | 5 ± 2 | 5 ± 2 |
| AHI (no. of events h−1 sleep) | 3 ± 4 | 3 ± 4 |
| Sleep efficiency (%) | 71 ± 15 | 75 ± 13 |
| N1 (% total sleep time) | 16 ± 8 | 21 ± 12 |
| N2 (% total sleep time) | 56 ± 10 | 65 ± 8* |
| Slow wave sleep (% total sleep time) | 13 ± 7 | 13 ± 9 |
| REM sleep (% total sleep time) | 15 ± 7 | 1 ± 1* |
| Arousal index (no. of arousals h−1 sleep) | 23 ± 10 | 26 ± 15 |
| Arousal duration (s) | 13 ± 3 | 14 ± 2 |
| Nadir SpO2 during sleep (%) | 92 ± 2 | 91 ± 3 |
| . | Placebo . | REB + HBB . |
|---|---|---|
| Karolinska sleepiness scale | 5 ± 2 | 5 ± 2 |
| AHI (no. of events h−1 sleep) | 3 ± 4 | 3 ± 4 |
| Sleep efficiency (%) | 71 ± 15 | 75 ± 13 |
| N1 (% total sleep time) | 16 ± 8 | 21 ± 12 |
| N2 (% total sleep time) | 56 ± 10 | 65 ± 8* |
| Slow wave sleep (% total sleep time) | 13 ± 7 | 13 ± 9 |
| REM sleep (% total sleep time) | 15 ± 7 | 1 ± 1* |
| Arousal index (no. of arousals h−1 sleep) | 23 ± 10 | 26 ± 15 |
| Arousal duration (s) | 13 ± 3 | 14 ± 2 |
| Nadir SpO2 during sleep (%) | 92 ± 2 | 91 ± 3 |
Polysomnography parameters (n = 10) except for rapid eye movement (REM) sleep (n = 3). AHI, apnea/hypopnea index, SpO2, arterial oxygen saturation estimated via pulse oximetry, REB, reboxetine and HBB, hyoscine butylbromide. Values are mean ± SD.
*Significant difference compared with placebo.
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