Associations Between Physical Activity Quartiles and Greater Perceived Physical Fatigability on Slower Gait Speed (m/s): The Long Life Family Study
| Probands (n = 295) . | . | . | Offspring (n = 1784) . | . | . |
|---|---|---|---|---|---|
| Model 0 | β Coefficient | p Value | Model 0 | β Coefficient | p Value |
| PA Quartiles (MET-hrs/d) | PA Quartiles (MET-hrs/d) | ||||
| QI (24.4 to <26.9) | −0.23 (−0.30, −0.16) | <.001 | QI (25.0 to <33.0) | −0.05 (−0.07, −0.02) | .001 |
| QII (26.9 to <30.0) | −0.09 (−0.15, −0.03) | .004 | QII (33.0 to <37.1) | −0.00 (−0.03, 0.03) | .941 |
| QIII (30.0 to <33.9) | −0.05 (−0.11, 0.01) | .075 | QIII (37.1 to <42.3) | −0.01 (−0.04, 0.02) | .423 |
| QIV (33.9 to 55.8) | Ref | QIV (42.3 to 71.7) | Ref | ||
| PFS Physical score/5pts | −0.04 (−0.05, −0.03) | <.001 | PFS Physical score/5pts | −0.04 (−0.05, −0.03) | <.001 |
| Model 1 | β Coefficient | p Value | Model 1 | β Coefficient | p Value |
| PA Quartiles (MET-hrs/d) | PA Quartiles (MET-hrs/d) | ||||
| QI (24.4 to <26.9) | −0.18 (−0.25, −0.11) | <.001 | QI (25.0 to <33.0) | −0.05 (−0.08, −0.02) | <.001 |
| QII (26.9 to <30.0) | −0.06 (−0.12, 0.00) | .055 | QII (33.0 to <37.1) | −0.01 (−0.03, 0.02) | .499 |
| QIII (30.0 to <33.9) | −0.03 (−0.08, 0.03) | .377 | QIII (37.1 to <42.3) | −0.02 (−0.04, 0.01) | .207 |
| QIV (33.9 to 55.8) | Ref | QIV (42.3 to 71.7) | Ref | ||
| PFS Physical score/5pts | −0.03 (−0.04, −0.02) | <.001 | PFS Physical score/5pts | −0.03 (−0.04, −0.03) | <.001 |
| Model 2 | β Coefficient | p Value | Model 2 | β Coefficient | p Value |
| PA Quartiles (MET-hrs/d) | PA Quartiles (MET-hrs/d) | ||||
| QI (24.4 to <26.9) | −0.17 (−0.23, −0.10) | <.001 | QI (25.0 to <33.0) | −0.04 (−0.06, −0.01) | .008 |
| QII (26.9 to <30.0) | −0.06 (−0.12, 0.00) | .062 | QII (33.0 to <37.1) | −0.01 (−0.04, 0.01) | .359 |
| QIII (30.0 to <33.9) | −0.02 (−0.08, 0.04) | .500 | QIII (37.1 to <42.3) | −0.02 (−0.04, 0.01) | .208 |
| QIV (33.9 to 55.8) | Ref | QIV (42.3 to 71.7) | Ref | ||
| PFS Physical score/5pts | −0.02 (−0.04, −0.01) | <.001 | PFS Physical score/5pts | −0.03 (−0.03, −0.02) | <.001 |
| Probands (n = 295) . | . | . | Offspring (n = 1784) . | . | . |
|---|---|---|---|---|---|
| Model 0 | β Coefficient | p Value | Model 0 | β Coefficient | p Value |
| PA Quartiles (MET-hrs/d) | PA Quartiles (MET-hrs/d) | ||||
| QI (24.4 to <26.9) | −0.23 (−0.30, −0.16) | <.001 | QI (25.0 to <33.0) | −0.05 (−0.07, −0.02) | .001 |
| QII (26.9 to <30.0) | −0.09 (−0.15, −0.03) | .004 | QII (33.0 to <37.1) | −0.00 (−0.03, 0.03) | .941 |
| QIII (30.0 to <33.9) | −0.05 (−0.11, 0.01) | .075 | QIII (37.1 to <42.3) | −0.01 (−0.04, 0.02) | .423 |
| QIV (33.9 to 55.8) | Ref | QIV (42.3 to 71.7) | Ref | ||
| PFS Physical score/5pts | −0.04 (−0.05, −0.03) | <.001 | PFS Physical score/5pts | −0.04 (−0.05, −0.03) | <.001 |
| Model 1 | β Coefficient | p Value | Model 1 | β Coefficient | p Value |
| PA Quartiles (MET-hrs/d) | PA Quartiles (MET-hrs/d) | ||||
| QI (24.4 to <26.9) | −0.18 (−0.25, −0.11) | <.001 | QI (25.0 to <33.0) | −0.05 (−0.08, −0.02) | <.001 |
| QII (26.9 to <30.0) | −0.06 (−0.12, 0.00) | .055 | QII (33.0 to <37.1) | −0.01 (−0.03, 0.02) | .499 |
| QIII (30.0 to <33.9) | −0.03 (−0.08, 0.03) | .377 | QIII (37.1 to <42.3) | −0.02 (−0.04, 0.01) | .207 |
| QIV (33.9 to 55.8) | Ref | QIV (42.3 to 71.7) | Ref | ||
| PFS Physical score/5pts | −0.03 (−0.04, −0.02) | <.001 | PFS Physical score/5pts | −0.03 (−0.04, −0.03) | <.001 |
| Model 2 | β Coefficient | p Value | Model 2 | β Coefficient | p Value |
| PA Quartiles (MET-hrs/d) | PA Quartiles (MET-hrs/d) | ||||
| QI (24.4 to <26.9) | −0.17 (−0.23, −0.10) | <.001 | QI (25.0 to <33.0) | −0.04 (−0.06, −0.01) | .008 |
| QII (26.9 to <30.0) | −0.06 (−0.12, 0.00) | .062 | QII (33.0 to <37.1) | −0.01 (−0.04, 0.01) | .359 |
| QIII (30.0 to <33.9) | −0.02 (−0.08, 0.04) | .500 | QIII (37.1 to <42.3) | −0.02 (−0.04, 0.01) | .208 |
| QIV (33.9 to 55.8) | Ref | QIV (42.3 to 71.7) | Ref | ||
| PFS Physical score/5pts | −0.02 (−0.04, −0.01) | <.001 | PFS Physical score/5pts | −0.03 (−0.03, −0.02) | <.001 |
Notes: MET = metabolic equivalent; PA = physical activity; PFS = Pittsburgh Fatigability Scale. Physical activity was measured with the Framingham Physical Activity Index and rescaled to every 5 MET-hours/d. Perceived physical fatigability was measured with the Pittsburgh Fatigability Scale (PFS, range 0–50) and rescaled to every 5 points. All models accounted for family structure. Model 0 adjusted for field center. Model 1 adjusted for age, sex, and field center. Model 2 adjusted for Model 1 + body mass index, smoking status, heart disease, stroke, hypertension, diabetes mellitus, lung disease, cancer (except for skin cancer), arthritis, and depressive symptoms.
Associations Between Physical Activity Quartiles and Greater Perceived Physical Fatigability on Slower Gait Speed (m/s): The Long Life Family Study
| Probands (n = 295) . | . | . | Offspring (n = 1784) . | . | . |
|---|---|---|---|---|---|
| Model 0 | β Coefficient | p Value | Model 0 | β Coefficient | p Value |
| PA Quartiles (MET-hrs/d) | PA Quartiles (MET-hrs/d) | ||||
| QI (24.4 to <26.9) | −0.23 (−0.30, −0.16) | <.001 | QI (25.0 to <33.0) | −0.05 (−0.07, −0.02) | .001 |
| QII (26.9 to <30.0) | −0.09 (−0.15, −0.03) | .004 | QII (33.0 to <37.1) | −0.00 (−0.03, 0.03) | .941 |
| QIII (30.0 to <33.9) | −0.05 (−0.11, 0.01) | .075 | QIII (37.1 to <42.3) | −0.01 (−0.04, 0.02) | .423 |
| QIV (33.9 to 55.8) | Ref | QIV (42.3 to 71.7) | Ref | ||
| PFS Physical score/5pts | −0.04 (−0.05, −0.03) | <.001 | PFS Physical score/5pts | −0.04 (−0.05, −0.03) | <.001 |
| Model 1 | β Coefficient | p Value | Model 1 | β Coefficient | p Value |
| PA Quartiles (MET-hrs/d) | PA Quartiles (MET-hrs/d) | ||||
| QI (24.4 to <26.9) | −0.18 (−0.25, −0.11) | <.001 | QI (25.0 to <33.0) | −0.05 (−0.08, −0.02) | <.001 |
| QII (26.9 to <30.0) | −0.06 (−0.12, 0.00) | .055 | QII (33.0 to <37.1) | −0.01 (−0.03, 0.02) | .499 |
| QIII (30.0 to <33.9) | −0.03 (−0.08, 0.03) | .377 | QIII (37.1 to <42.3) | −0.02 (−0.04, 0.01) | .207 |
| QIV (33.9 to 55.8) | Ref | QIV (42.3 to 71.7) | Ref | ||
| PFS Physical score/5pts | −0.03 (−0.04, −0.02) | <.001 | PFS Physical score/5pts | −0.03 (−0.04, −0.03) | <.001 |
| Model 2 | β Coefficient | p Value | Model 2 | β Coefficient | p Value |
| PA Quartiles (MET-hrs/d) | PA Quartiles (MET-hrs/d) | ||||
| QI (24.4 to <26.9) | −0.17 (−0.23, −0.10) | <.001 | QI (25.0 to <33.0) | −0.04 (−0.06, −0.01) | .008 |
| QII (26.9 to <30.0) | −0.06 (−0.12, 0.00) | .062 | QII (33.0 to <37.1) | −0.01 (−0.04, 0.01) | .359 |
| QIII (30.0 to <33.9) | −0.02 (−0.08, 0.04) | .500 | QIII (37.1 to <42.3) | −0.02 (−0.04, 0.01) | .208 |
| QIV (33.9 to 55.8) | Ref | QIV (42.3 to 71.7) | Ref | ||
| PFS Physical score/5pts | −0.02 (−0.04, −0.01) | <.001 | PFS Physical score/5pts | −0.03 (−0.03, −0.02) | <.001 |
| Probands (n = 295) . | . | . | Offspring (n = 1784) . | . | . |
|---|---|---|---|---|---|
| Model 0 | β Coefficient | p Value | Model 0 | β Coefficient | p Value |
| PA Quartiles (MET-hrs/d) | PA Quartiles (MET-hrs/d) | ||||
| QI (24.4 to <26.9) | −0.23 (−0.30, −0.16) | <.001 | QI (25.0 to <33.0) | −0.05 (−0.07, −0.02) | .001 |
| QII (26.9 to <30.0) | −0.09 (−0.15, −0.03) | .004 | QII (33.0 to <37.1) | −0.00 (−0.03, 0.03) | .941 |
| QIII (30.0 to <33.9) | −0.05 (−0.11, 0.01) | .075 | QIII (37.1 to <42.3) | −0.01 (−0.04, 0.02) | .423 |
| QIV (33.9 to 55.8) | Ref | QIV (42.3 to 71.7) | Ref | ||
| PFS Physical score/5pts | −0.04 (−0.05, −0.03) | <.001 | PFS Physical score/5pts | −0.04 (−0.05, −0.03) | <.001 |
| Model 1 | β Coefficient | p Value | Model 1 | β Coefficient | p Value |
| PA Quartiles (MET-hrs/d) | PA Quartiles (MET-hrs/d) | ||||
| QI (24.4 to <26.9) | −0.18 (−0.25, −0.11) | <.001 | QI (25.0 to <33.0) | −0.05 (−0.08, −0.02) | <.001 |
| QII (26.9 to <30.0) | −0.06 (−0.12, 0.00) | .055 | QII (33.0 to <37.1) | −0.01 (−0.03, 0.02) | .499 |
| QIII (30.0 to <33.9) | −0.03 (−0.08, 0.03) | .377 | QIII (37.1 to <42.3) | −0.02 (−0.04, 0.01) | .207 |
| QIV (33.9 to 55.8) | Ref | QIV (42.3 to 71.7) | Ref | ||
| PFS Physical score/5pts | −0.03 (−0.04, −0.02) | <.001 | PFS Physical score/5pts | −0.03 (−0.04, −0.03) | <.001 |
| Model 2 | β Coefficient | p Value | Model 2 | β Coefficient | p Value |
| PA Quartiles (MET-hrs/d) | PA Quartiles (MET-hrs/d) | ||||
| QI (24.4 to <26.9) | −0.17 (−0.23, −0.10) | <.001 | QI (25.0 to <33.0) | −0.04 (−0.06, −0.01) | .008 |
| QII (26.9 to <30.0) | −0.06 (−0.12, 0.00) | .062 | QII (33.0 to <37.1) | −0.01 (−0.04, 0.01) | .359 |
| QIII (30.0 to <33.9) | −0.02 (−0.08, 0.04) | .500 | QIII (37.1 to <42.3) | −0.02 (−0.04, 0.01) | .208 |
| QIV (33.9 to 55.8) | Ref | QIV (42.3 to 71.7) | Ref | ||
| PFS Physical score/5pts | −0.02 (−0.04, −0.01) | <.001 | PFS Physical score/5pts | −0.03 (−0.03, −0.02) | <.001 |
Notes: MET = metabolic equivalent; PA = physical activity; PFS = Pittsburgh Fatigability Scale. Physical activity was measured with the Framingham Physical Activity Index and rescaled to every 5 MET-hours/d. Perceived physical fatigability was measured with the Pittsburgh Fatigability Scale (PFS, range 0–50) and rescaled to every 5 points. All models accounted for family structure. Model 0 adjusted for field center. Model 1 adjusted for age, sex, and field center. Model 2 adjusted for Model 1 + body mass index, smoking status, heart disease, stroke, hypertension, diabetes mellitus, lung disease, cancer (except for skin cancer), arthritis, and depressive symptoms.
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