Visit 2 Characteristics by Proband and Offspring Generations: The Long Life Family Study (N = 2079)
| Characteristics . | All (N = 2079) . | Probands (n = 295) . | Offspring (n = 1784) . | p Value . |
|---|---|---|---|---|
| Age, years | 73.0 ± 10.0 | 92.2 ± 6.9 | 69.9 ± 6.3 | <.001 |
| Women | 1127 (54.2) | 183 (62.0) | 944 (52.9) | .004 |
| Body mass index, kg/m2 | 27.5 ± 5.2 | 26.2 ± 5.0 | 27.7 ± 5.2 | <.001 |
| Current smoker | 115 (5.5) | 6 (2.0) | 109 (6.1) | .005 |
| Heart disease | 110 (5.3) | 46 (15.6) | 64 (3.6) | <.001 |
| Stroke | 69 (3.3) | 25 (8.5) | 44 (2.5) | <.001 |
| Hypertension* | 1277 (61.4) | 205 (69.5) | 1072 (60.1) | .002 |
| Diabetes mellitus† | 226 (10.9) | 43 (14.6) | 183 (10.3) | .027 |
| Lung disease | 261 (12.6) | 37 (12.5) | 224 (12.6) | .995 |
| Cancer | 410 (19.7) | 84 (28.5) | 326 (18.3) | <.001 |
| Arthritis | 604 (29.1) | 128 (43.4) | 476 (26.7) | <.001 |
| Depression symptoms (CES-D), 0–30 | 3.2 ± 3.4 | 4.4 ± 3.7 | 3.0 ± 3.3 | <.001 |
| Physical activity‡, MET-hrs/d | 37.0 ± 7.1 | 31.1 ± 5.3 | 38.0 ± 6.9 | <.001 |
| PFS Physical score, 0–50 | 13.5 ± 9.7 | 24.4 ± 10.6 | 11.7 ± 8.3 | <.001 |
| Usual-paced gait speed, m/s | 1.02 ± 0.27 | 0.66 ± 0.23 | 1.08 ± 0.22 | <.001 |
| Characteristics . | All (N = 2079) . | Probands (n = 295) . | Offspring (n = 1784) . | p Value . |
|---|---|---|---|---|
| Age, years | 73.0 ± 10.0 | 92.2 ± 6.9 | 69.9 ± 6.3 | <.001 |
| Women | 1127 (54.2) | 183 (62.0) | 944 (52.9) | .004 |
| Body mass index, kg/m2 | 27.5 ± 5.2 | 26.2 ± 5.0 | 27.7 ± 5.2 | <.001 |
| Current smoker | 115 (5.5) | 6 (2.0) | 109 (6.1) | .005 |
| Heart disease | 110 (5.3) | 46 (15.6) | 64 (3.6) | <.001 |
| Stroke | 69 (3.3) | 25 (8.5) | 44 (2.5) | <.001 |
| Hypertension* | 1277 (61.4) | 205 (69.5) | 1072 (60.1) | .002 |
| Diabetes mellitus† | 226 (10.9) | 43 (14.6) | 183 (10.3) | .027 |
| Lung disease | 261 (12.6) | 37 (12.5) | 224 (12.6) | .995 |
| Cancer | 410 (19.7) | 84 (28.5) | 326 (18.3) | <.001 |
| Arthritis | 604 (29.1) | 128 (43.4) | 476 (26.7) | <.001 |
| Depression symptoms (CES-D), 0–30 | 3.2 ± 3.4 | 4.4 ± 3.7 | 3.0 ± 3.3 | <.001 |
| Physical activity‡, MET-hrs/d | 37.0 ± 7.1 | 31.1 ± 5.3 | 38.0 ± 6.9 | <.001 |
| PFS Physical score, 0–50 | 13.5 ± 9.7 | 24.4 ± 10.6 | 11.7 ± 8.3 | <.001 |
| Usual-paced gait speed, m/s | 1.02 ± 0.27 | 0.66 ± 0.23 | 1.08 ± 0.22 | <.001 |
Notes: CES-D = Center for Epidemiologic Studies-Depression scale; MET = metabolic equivalent; PFS = Pittsburgh Fatigability Scale (higher scores = greater perceived fatigability); SD = standard deviation. All reported in mean ± SD or n (%).
*Hypertension is defined by systolic blood pressure ≥130 mmHg and/or diastolic blood pressure ≥80 mmHg.
†Diabetes mellitus is defined by hemoglobin A1c ≥6.5.
‡Physical activity was measured with the Framingham Physical Activity Index.
Visit 2 Characteristics by Proband and Offspring Generations: The Long Life Family Study (N = 2079)
| Characteristics . | All (N = 2079) . | Probands (n = 295) . | Offspring (n = 1784) . | p Value . |
|---|---|---|---|---|
| Age, years | 73.0 ± 10.0 | 92.2 ± 6.9 | 69.9 ± 6.3 | <.001 |
| Women | 1127 (54.2) | 183 (62.0) | 944 (52.9) | .004 |
| Body mass index, kg/m2 | 27.5 ± 5.2 | 26.2 ± 5.0 | 27.7 ± 5.2 | <.001 |
| Current smoker | 115 (5.5) | 6 (2.0) | 109 (6.1) | .005 |
| Heart disease | 110 (5.3) | 46 (15.6) | 64 (3.6) | <.001 |
| Stroke | 69 (3.3) | 25 (8.5) | 44 (2.5) | <.001 |
| Hypertension* | 1277 (61.4) | 205 (69.5) | 1072 (60.1) | .002 |
| Diabetes mellitus† | 226 (10.9) | 43 (14.6) | 183 (10.3) | .027 |
| Lung disease | 261 (12.6) | 37 (12.5) | 224 (12.6) | .995 |
| Cancer | 410 (19.7) | 84 (28.5) | 326 (18.3) | <.001 |
| Arthritis | 604 (29.1) | 128 (43.4) | 476 (26.7) | <.001 |
| Depression symptoms (CES-D), 0–30 | 3.2 ± 3.4 | 4.4 ± 3.7 | 3.0 ± 3.3 | <.001 |
| Physical activity‡, MET-hrs/d | 37.0 ± 7.1 | 31.1 ± 5.3 | 38.0 ± 6.9 | <.001 |
| PFS Physical score, 0–50 | 13.5 ± 9.7 | 24.4 ± 10.6 | 11.7 ± 8.3 | <.001 |
| Usual-paced gait speed, m/s | 1.02 ± 0.27 | 0.66 ± 0.23 | 1.08 ± 0.22 | <.001 |
| Characteristics . | All (N = 2079) . | Probands (n = 295) . | Offspring (n = 1784) . | p Value . |
|---|---|---|---|---|
| Age, years | 73.0 ± 10.0 | 92.2 ± 6.9 | 69.9 ± 6.3 | <.001 |
| Women | 1127 (54.2) | 183 (62.0) | 944 (52.9) | .004 |
| Body mass index, kg/m2 | 27.5 ± 5.2 | 26.2 ± 5.0 | 27.7 ± 5.2 | <.001 |
| Current smoker | 115 (5.5) | 6 (2.0) | 109 (6.1) | .005 |
| Heart disease | 110 (5.3) | 46 (15.6) | 64 (3.6) | <.001 |
| Stroke | 69 (3.3) | 25 (8.5) | 44 (2.5) | <.001 |
| Hypertension* | 1277 (61.4) | 205 (69.5) | 1072 (60.1) | .002 |
| Diabetes mellitus† | 226 (10.9) | 43 (14.6) | 183 (10.3) | .027 |
| Lung disease | 261 (12.6) | 37 (12.5) | 224 (12.6) | .995 |
| Cancer | 410 (19.7) | 84 (28.5) | 326 (18.3) | <.001 |
| Arthritis | 604 (29.1) | 128 (43.4) | 476 (26.7) | <.001 |
| Depression symptoms (CES-D), 0–30 | 3.2 ± 3.4 | 4.4 ± 3.7 | 3.0 ± 3.3 | <.001 |
| Physical activity‡, MET-hrs/d | 37.0 ± 7.1 | 31.1 ± 5.3 | 38.0 ± 6.9 | <.001 |
| PFS Physical score, 0–50 | 13.5 ± 9.7 | 24.4 ± 10.6 | 11.7 ± 8.3 | <.001 |
| Usual-paced gait speed, m/s | 1.02 ± 0.27 | 0.66 ± 0.23 | 1.08 ± 0.22 | <.001 |
Notes: CES-D = Center for Epidemiologic Studies-Depression scale; MET = metabolic equivalent; PFS = Pittsburgh Fatigability Scale (higher scores = greater perceived fatigability); SD = standard deviation. All reported in mean ± SD or n (%).
*Hypertension is defined by systolic blood pressure ≥130 mmHg and/or diastolic blood pressure ≥80 mmHg.
†Diabetes mellitus is defined by hemoglobin A1c ≥6.5.
‡Physical activity was measured with the Framingham Physical Activity Index.
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