| ADNI . | CN Aβ− (n = 184) . | CN Aβ+ (n = 89) . | MCI Aβ+ (n = 59) . | Alzheimer’s disease dementia (n = 8) . | P-value . |
|---|---|---|---|---|---|
| Age | 72.3 (6.8) | 75.8 (6.6) | 76.3 (7.5) | 73.5 (11.5) | <0.001 |
| Gender, female/male | 112/72 | 56/33 | 25/34 | 3/5 | 0.033 |
| Education | 16.9 (2.3) | 16.4 (2.5) | 15.8 (2.7) | 16.3 (2.3) | 0.010 |
| ADAS13 | 12.2 (4.6) | 13.6 (5.6) | 22.8 (10.5) | 31.7 (8.6) | <0.001 |
| DIAN | Non-carrier (n = 71) | Mutation-carrier (n = 108) | |||
| Age | 38.1 (10.3) | 38.0 (10.5) | 0.953 | ||
| EYO | −9.8 (11.0) | −8.6 (11.2) | 0.470 | ||
| Gender, female/male | 44/27 | 68/40 | 0.990 | ||
| Education | 15.2 (3.1) | 14.2 (3.3) | 0.033 | ||
| Global cognitive composite | 0.19 (0.2) | −0.15 (0.5) | <0.001 | ||
| ADNI . | CN Aβ− (n = 184) . | CN Aβ+ (n = 89) . | MCI Aβ+ (n = 59) . | Alzheimer’s disease dementia (n = 8) . | P-value . |
|---|---|---|---|---|---|
| Age | 72.3 (6.8) | 75.8 (6.6) | 76.3 (7.5) | 73.5 (11.5) | <0.001 |
| Gender, female/male | 112/72 | 56/33 | 25/34 | 3/5 | 0.033 |
| Education | 16.9 (2.3) | 16.4 (2.5) | 15.8 (2.7) | 16.3 (2.3) | 0.010 |
| ADAS13 | 12.2 (4.6) | 13.6 (5.6) | 22.8 (10.5) | 31.7 (8.6) | <0.001 |
| DIAN | Non-carrier (n = 71) | Mutation-carrier (n = 108) | |||
| Age | 38.1 (10.3) | 38.0 (10.5) | 0.953 | ||
| EYO | −9.8 (11.0) | −8.6 (11.2) | 0.470 | ||
| Gender, female/male | 44/27 | 68/40 | 0.990 | ||
| Education | 15.2 (3.1) | 14.2 (3.3) | 0.033 | ||
| Global cognitive composite | 0.19 (0.2) | −0.15 (0.5) | <0.001 | ||
The classification of amyloid-β-positive (Aβ+) or amyloid-β-negative (Aβ−) status was based on a previously established cut-off point (global AV45 SUVR > 1.11).36 For continuous measures, the mean (SD) are displayed. CN = cognitively normal; MCI = mild cognitive impairment.
| ADNI . | CN Aβ− (n = 184) . | CN Aβ+ (n = 89) . | MCI Aβ+ (n = 59) . | Alzheimer’s disease dementia (n = 8) . | P-value . |
|---|---|---|---|---|---|
| Age | 72.3 (6.8) | 75.8 (6.6) | 76.3 (7.5) | 73.5 (11.5) | <0.001 |
| Gender, female/male | 112/72 | 56/33 | 25/34 | 3/5 | 0.033 |
| Education | 16.9 (2.3) | 16.4 (2.5) | 15.8 (2.7) | 16.3 (2.3) | 0.010 |
| ADAS13 | 12.2 (4.6) | 13.6 (5.6) | 22.8 (10.5) | 31.7 (8.6) | <0.001 |
| DIAN | Non-carrier (n = 71) | Mutation-carrier (n = 108) | |||
| Age | 38.1 (10.3) | 38.0 (10.5) | 0.953 | ||
| EYO | −9.8 (11.0) | −8.6 (11.2) | 0.470 | ||
| Gender, female/male | 44/27 | 68/40 | 0.990 | ||
| Education | 15.2 (3.1) | 14.2 (3.3) | 0.033 | ||
| Global cognitive composite | 0.19 (0.2) | −0.15 (0.5) | <0.001 | ||
| ADNI . | CN Aβ− (n = 184) . | CN Aβ+ (n = 89) . | MCI Aβ+ (n = 59) . | Alzheimer’s disease dementia (n = 8) . | P-value . |
|---|---|---|---|---|---|
| Age | 72.3 (6.8) | 75.8 (6.6) | 76.3 (7.5) | 73.5 (11.5) | <0.001 |
| Gender, female/male | 112/72 | 56/33 | 25/34 | 3/5 | 0.033 |
| Education | 16.9 (2.3) | 16.4 (2.5) | 15.8 (2.7) | 16.3 (2.3) | 0.010 |
| ADAS13 | 12.2 (4.6) | 13.6 (5.6) | 22.8 (10.5) | 31.7 (8.6) | <0.001 |
| DIAN | Non-carrier (n = 71) | Mutation-carrier (n = 108) | |||
| Age | 38.1 (10.3) | 38.0 (10.5) | 0.953 | ||
| EYO | −9.8 (11.0) | −8.6 (11.2) | 0.470 | ||
| Gender, female/male | 44/27 | 68/40 | 0.990 | ||
| Education | 15.2 (3.1) | 14.2 (3.3) | 0.033 | ||
| Global cognitive composite | 0.19 (0.2) | −0.15 (0.5) | <0.001 | ||
The classification of amyloid-β-positive (Aβ+) or amyloid-β-negative (Aβ−) status was based on a previously established cut-off point (global AV45 SUVR > 1.11).36 For continuous measures, the mean (SD) are displayed. CN = cognitively normal; MCI = mild cognitive impairment.
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