Table 3. Open in new tab Multivariate...

	Univariate (Unadjusted)	Multivariate (Adjusted)
Patients presenting with ESD plus PSD
DQA1*03	20.00	41.50	0.35	.17–.68	.001	0.48	.24–.92	−2.129	1.03	.033
DRB104/DRB113	0.00	9.00	0.00	.00–.57	.005	0.00	0–3 × 10⁺¹⁹	−0.017	1.03	.986
DRB103/DQA101/DQB1*02	12.00	1.00	13.35	2.67–130.25	.0002	10.30	2.38–72.23	2.809	1.03	.005
Patients presenting with only ESD
DQA1*03	13.80	41.50	0.23	.06–.69	.004	0.30	.08–.89	−2.016	0.69	.044
DQA101/DQB106	41.40	17.00	3.42	1.36–8.43	.005	2.17	.88–5.30	1.709	0.69	.087
Patients presenting with only PSD
DRB1*03 allele/dimer	28.30	8.00	4.49	1.81–11.05	.0005	3.34	1.27–8.69	2.473	0.81	.013
DRB1*13 allele/dimer	10.90	33.00	0.25	.07–.67	.002	0.25	.08–.67	−2.566	0.81	.010
DQA101/DQA105	34.80	12.50	3.71	1.65–8.24	.0007	3.56	1.48–8.53	2.863	0.81	.004

Univariate (Unadjusted)

Multivariate (Adjusted)

Variables

ESD + PSD, ESD, or PSD, %

Control, %

95% CI

Z Value

Model Dispersion Coefficient^a

Patients presenting with ESD plus PSD

DQA1*03

20.00

41.50

0.35

.17–.68

.001

0.48

.24–.92

−2.129

1.03

.033

DRB1*04/DRB1*13

0.00

9.00

0.00

.00–.57

.005

0.00

0–3 × 10⁺¹⁹

−0.017

1.03

.986

DRB1*03/DQA1*01/DQB1*02

12.00

1.00

13.35

2.67–130.25

.0002

10.30

2.38–72.23

2.809

1.03

.005

Patients presenting with only ESD

DQA1*03

13.80

41.50

0.23

.06–.69

.004

0.30

.08–.89

−2.016

0.69

.044

DQA1*01/DQB1*06

41.40

17.00

3.42

1.36–8.43

.005

2.17

.88–5.30

1.709

0.69

.087

Patients presenting with only PSD

DRB1*03 allele/dimer

28.30

8.00

4.49

1.81–11.05

.0005

3.34

1.27–8.69

2.473

0.81

.013

DRB1*13 allele/dimer

10.90

33.00

0.25

.07–.67

.002

0.25

.08–.67

−2.566

0.81

.010

DQA1*01/DQA1*05

34.80

12.50

3.71

1.65–8.24

.0007

3.56

1.48–8.53

2.863

0.81

.004

	Univariate (Unadjusted)	Multivariate (Adjusted)
Patients presenting with ESD plus PSD
DQA1*03	20.00	41.50	0.35	.17–.68	.001	0.48	.24–.92	−2.129	1.03	.033
DRB104/DRB113	0.00	9.00	0.00	.00–.57	.005	0.00	0–3 × 10⁺¹⁹	−0.017	1.03	.986
DRB103/DQA101/DQB1*02	12.00	1.00	13.35	2.67–130.25	.0002	10.30	2.38–72.23	2.809	1.03	.005
Patients presenting with only ESD
DQA1*03	13.80	41.50	0.23	.06–.69	.004	0.30	.08–.89	−2.016	0.69	.044
DQA101/DQB106	41.40	17.00	3.42	1.36–8.43	.005	2.17	.88–5.30	1.709	0.69	.087
Patients presenting with only PSD
DRB1*03 allele/dimer	28.30	8.00	4.49	1.81–11.05	.0005	3.34	1.27–8.69	2.473	0.81	.013
DRB1*13 allele/dimer	10.90	33.00	0.25	.07–.67	.002	0.25	.08–.67	−2.566	0.81	.010
DQA101/DQA105	34.80	12.50	3.71	1.65–8.24	.0007	3.56	1.48–8.53	2.863	0.81	.004

Table 3.

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Multivariate Analyses for Comparisons of HLA-DRB1, DQA1, and DQB1 Alleles, Genotypes, Dimers, and Extended Haplotypes, Exhibiting P Value ≤ .005 in Univariate Analysis Between Patients Presenting With ESD Plus PSD, Only ESD, and Only PSD Versus Controls

	Univariate (Unadjusted)					Multivariate (Adjusted)
Variables	ESD + PSD, ESD, or PSD, %	Control, %	OR	95% CI	P	OR	95% CI	Z Value	Model Dispersion Coefficient^a	P
Patients presenting with ESD plus PSD
DQA1*03	20.00	41.50	0.35	.17–.68	.001	0.48	.24–.92	−2.129	1.03	.033
DRB104/DRB113	0.00	9.00	0.00	.00–.57	.005	0.00	0–3 × 10⁺¹⁹	−0.017	1.03	.986
DRB103/DQA101/DQB1*02	12.00	1.00	13.35	2.67–130.25	.0002	10.30	2.38–72.23	2.809	1.03	.005
Patients presenting with only ESD
DQA1*03	13.80	41.50	0.23	.06–.69	.004	0.30	.08–.89	−2.016	0.69	.044
DQA101/DQB106	41.40	17.00	3.42	1.36–8.43	.005	2.17	.88–5.30	1.709	0.69	.087
Patients presenting with only PSD
DRB1*03 allele/dimer	28.30	8.00	4.49	1.81–11.05	.0005	3.34	1.27–8.69	2.473	0.81	.013
DRB1*13 allele/dimer	10.90	33.00	0.25	.07–.67	.002	0.25	.08–.67	−2.566	0.81	.010
DQA101/DQA105	34.80	12.50	3.71	1.65–8.24	.0007	3.56	1.48–8.53	2.863	0.81	.004

	Univariate (Unadjusted)					Multivariate (Adjusted)
Variables	ESD + PSD, ESD, or PSD, %	Control, %	OR	95% CI	P	OR	95% CI	Z Value	Model Dispersion Coefficient^a	P
Patients presenting with ESD plus PSD
DQA1*03	20.00	41.50	0.35	.17–.68	.001	0.48	.24–.92	−2.129	1.03	.033
DRB104/DRB113	0.00	9.00	0.00	.00–.57	.005	0.00	0–3 × 10⁺¹⁹	−0.017	1.03	.986
DRB103/DQA101/DQB1*02	12.00	1.00	13.35	2.67–130.25	.0002	10.30	2.38–72.23	2.809	1.03	.005
Patients presenting with only ESD
DQA1*03	13.80	41.50	0.23	.06–.69	.004	0.30	.08–.89	−2.016	0.69	.044
DQA101/DQB106	41.40	17.00	3.42	1.36–8.43	.005	2.17	.88–5.30	1.709	0.69	.087
Patients presenting with only PSD
DRB1*03 allele/dimer	28.30	8.00	4.49	1.81–11.05	.0005	3.34	1.27–8.69	2.473	0.81	.013
DRB1*13 allele/dimer	10.90	33.00	0.25	.07–.67	.002	0.25	.08–.67	−2.566	0.81	.010
DQA101/DQA105	34.80	12.50	3.71	1.65–8.24	.0007	3.56	1.48–8.53	2.863	0.81	.004

Significant multivariate P values adjusted by sex and age are shown in bold.

Abbreviations: CI, confidence interval; ESD, neurological encephalitis spectrum; OR, odds ratio; PSD, peripheral spectrum disorders.

^aModel dispersion is summary(model.final)$deviance / summary(model.final)$df.residual ratio. The model is dispersed when this ratio exceeds 1.5.

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