Multivariate Analyses for Comparisons of HLA-DRB1, DQA1, and DQB1 Alleles, Genotypes, Dimers, and Extended Haplotypes, Exhibiting P Value ≤ .005 in Univariate Analysis Between the Whole Group of Patients With Arbovirus (ZIKV, DENV, and CHIKV) Infections Versus Controls
| . | Univariate (Unadjusted) . | Multivariate (Adjusted) . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variables . | Patient, % . | Control, % . | OR . | 95% CI . | P . | OR . | 95% CI . | Z Value . | Model Dispersion Coefficienta . | P . |
| DRB1*04 allele/dimer | 15.70 | 36.50 | 0.33 | .16–.63 | .0003 | 0.49 | .23–.96 | −2.010 | 1.06 | .044 |
| DRB1*15 allele/dimer | 36.00 | 18.50 | 2.47 | 1.35–4.49 | .002 | 1.66 | .88–3.11 | 1.570 | 1.06 | .116 |
| DRB1*04/DRB1*13 | 0.00 | 9.00 | 0.00 | .00–.46 | .001 | 0.00 | 0–1 × 10+20 | −0.018 | 1.06 | .986 |
| DRB1*03/DQA1*01/DQB1*02 | 11.10 | 1.00 | 12.26 | 2.53–117.64 | .0002 | 8.51 | 1.91–60.75 | 2.540 | 1.06 | .011 |
| . | Univariate (Unadjusted) . | Multivariate (Adjusted) . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variables . | Patient, % . | Control, % . | OR . | 95% CI . | P . | OR . | 95% CI . | Z Value . | Model Dispersion Coefficienta . | P . |
| DRB1*04 allele/dimer | 15.70 | 36.50 | 0.33 | .16–.63 | .0003 | 0.49 | .23–.96 | −2.010 | 1.06 | .044 |
| DRB1*15 allele/dimer | 36.00 | 18.50 | 2.47 | 1.35–4.49 | .002 | 1.66 | .88–3.11 | 1.570 | 1.06 | .116 |
| DRB1*04/DRB1*13 | 0.00 | 9.00 | 0.00 | .00–.46 | .001 | 0.00 | 0–1 × 10+20 | −0.018 | 1.06 | .986 |
| DRB1*03/DQA1*01/DQB1*02 | 11.10 | 1.00 | 12.26 | 2.53–117.64 | .0002 | 8.51 | 1.91–60.75 | 2.540 | 1.06 | .011 |
Significant multivariate P values adjusted by sex and age are shown in bold.
Abbreviations: CHIKV, chikungunya virus; CI, confidence interval; DENV, dengue virus; OR, odds ratio; ZIKV, Zika virus.
aModel dispersion is the summary(model.final)$deviance/summary(model.final)$df.residual ratio. The model is dispersed when this ratio exceeds 1.5.
Multivariate Analyses for Comparisons of HLA-DRB1, DQA1, and DQB1 Alleles, Genotypes, Dimers, and Extended Haplotypes, Exhibiting P Value ≤ .005 in Univariate Analysis Between the Whole Group of Patients With Arbovirus (ZIKV, DENV, and CHIKV) Infections Versus Controls
| . | Univariate (Unadjusted) . | Multivariate (Adjusted) . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variables . | Patient, % . | Control, % . | OR . | 95% CI . | P . | OR . | 95% CI . | Z Value . | Model Dispersion Coefficienta . | P . |
| DRB1*04 allele/dimer | 15.70 | 36.50 | 0.33 | .16–.63 | .0003 | 0.49 | .23–.96 | −2.010 | 1.06 | .044 |
| DRB1*15 allele/dimer | 36.00 | 18.50 | 2.47 | 1.35–4.49 | .002 | 1.66 | .88–3.11 | 1.570 | 1.06 | .116 |
| DRB1*04/DRB1*13 | 0.00 | 9.00 | 0.00 | .00–.46 | .001 | 0.00 | 0–1 × 10+20 | −0.018 | 1.06 | .986 |
| DRB1*03/DQA1*01/DQB1*02 | 11.10 | 1.00 | 12.26 | 2.53–117.64 | .0002 | 8.51 | 1.91–60.75 | 2.540 | 1.06 | .011 |
| . | Univariate (Unadjusted) . | Multivariate (Adjusted) . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variables . | Patient, % . | Control, % . | OR . | 95% CI . | P . | OR . | 95% CI . | Z Value . | Model Dispersion Coefficienta . | P . |
| DRB1*04 allele/dimer | 15.70 | 36.50 | 0.33 | .16–.63 | .0003 | 0.49 | .23–.96 | −2.010 | 1.06 | .044 |
| DRB1*15 allele/dimer | 36.00 | 18.50 | 2.47 | 1.35–4.49 | .002 | 1.66 | .88–3.11 | 1.570 | 1.06 | .116 |
| DRB1*04/DRB1*13 | 0.00 | 9.00 | 0.00 | .00–.46 | .001 | 0.00 | 0–1 × 10+20 | −0.018 | 1.06 | .986 |
| DRB1*03/DQA1*01/DQB1*02 | 11.10 | 1.00 | 12.26 | 2.53–117.64 | .0002 | 8.51 | 1.91–60.75 | 2.540 | 1.06 | .011 |
Significant multivariate P values adjusted by sex and age are shown in bold.
Abbreviations: CHIKV, chikungunya virus; CI, confidence interval; DENV, dengue virus; OR, odds ratio; ZIKV, Zika virus.
aModel dispersion is the summary(model.final)$deviance/summary(model.final)$df.residual ratio. The model is dispersed when this ratio exceeds 1.5.
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