| Infection | A pathologic process caused by the invasion of normally sterile tissue or fluid or body cavity by pathogenic or potentially pathogenic microorganisms |
| Signs and symptoms of infection | Requires any two of the following signs and symptoms both present and new to the patient: temperature >38.3°C or <36.0°C; heart rate >90 beat min−1; respiratory rate >20 bpm; acutely altered mental status; leucocytosis—WBC >12 000 μl−1; leucopaenia—WBC <4000 μl−1; hyperglycaemia (plasma glucose >7.7 mmol litre-1) in the absence of diabetes; plasma C-reactive protein >2 sd above the normal value |
| Sepsis | The clinical syndrome defined by the presence of both signs and symptoms of infection as described above and documented or suspected new infection |
| Severe sepsis | Sepsis complicated by one organ dysfunction |
| Multi-organ failure | Two or more organ dysfunction |
| Organ dysfunction | Defined using the definitions used for the Sequential Organ Failure Assessment (SOFA) score:40Pao2/Fio2≤26.7 kPa; noradrenaline/adrenaline ≥0.1 μg kg−1 min−1; creatinine ≥330 μmol litre−1; platelets ≤50×103 ml−1; bilirubin ≥102 μmol litre−1; Glasgow Coma Score <9 |
| Septic shock | In adults applies to a state of acute circulatory failure unexplained by other causes, defined as persistent arterial hypotension [a systolic arterial pressure (SBP) <90, MAP<60, or a reduction in SBP 40 mm Hg from baseline despite adequate volume resuscitation] |
| Infection | A pathologic process caused by the invasion of normally sterile tissue or fluid or body cavity by pathogenic or potentially pathogenic microorganisms |
| Signs and symptoms of infection | Requires any two of the following signs and symptoms both present and new to the patient: temperature >38.3°C or <36.0°C; heart rate >90 beat min−1; respiratory rate >20 bpm; acutely altered mental status; leucocytosis—WBC >12 000 μl−1; leucopaenia—WBC <4000 μl−1; hyperglycaemia (plasma glucose >7.7 mmol litre-1) in the absence of diabetes; plasma C-reactive protein >2 sd above the normal value |
| Sepsis | The clinical syndrome defined by the presence of both signs and symptoms of infection as described above and documented or suspected new infection |
| Severe sepsis | Sepsis complicated by one organ dysfunction |
| Multi-organ failure | Two or more organ dysfunction |
| Organ dysfunction | Defined using the definitions used for the Sequential Organ Failure Assessment (SOFA) score:40Pao2/Fio2≤26.7 kPa; noradrenaline/adrenaline ≥0.1 μg kg−1 min−1; creatinine ≥330 μmol litre−1; platelets ≤50×103 ml−1; bilirubin ≥102 μmol litre−1; Glasgow Coma Score <9 |
| Septic shock | In adults applies to a state of acute circulatory failure unexplained by other causes, defined as persistent arterial hypotension [a systolic arterial pressure (SBP) <90, MAP<60, or a reduction in SBP 40 mm Hg from baseline despite adequate volume resuscitation] |
| Infection | A pathologic process caused by the invasion of normally sterile tissue or fluid or body cavity by pathogenic or potentially pathogenic microorganisms |
| Signs and symptoms of infection | Requires any two of the following signs and symptoms both present and new to the patient: temperature >38.3°C or <36.0°C; heart rate >90 beat min−1; respiratory rate >20 bpm; acutely altered mental status; leucocytosis—WBC >12 000 μl−1; leucopaenia—WBC <4000 μl−1; hyperglycaemia (plasma glucose >7.7 mmol litre-1) in the absence of diabetes; plasma C-reactive protein >2 sd above the normal value |
| Sepsis | The clinical syndrome defined by the presence of both signs and symptoms of infection as described above and documented or suspected new infection |
| Severe sepsis | Sepsis complicated by one organ dysfunction |
| Multi-organ failure | Two or more organ dysfunction |
| Organ dysfunction | Defined using the definitions used for the Sequential Organ Failure Assessment (SOFA) score:40Pao2/Fio2≤26.7 kPa; noradrenaline/adrenaline ≥0.1 μg kg−1 min−1; creatinine ≥330 μmol litre−1; platelets ≤50×103 ml−1; bilirubin ≥102 μmol litre−1; Glasgow Coma Score <9 |
| Septic shock | In adults applies to a state of acute circulatory failure unexplained by other causes, defined as persistent arterial hypotension [a systolic arterial pressure (SBP) <90, MAP<60, or a reduction in SBP 40 mm Hg from baseline despite adequate volume resuscitation] |
| Infection | A pathologic process caused by the invasion of normally sterile tissue or fluid or body cavity by pathogenic or potentially pathogenic microorganisms |
| Signs and symptoms of infection | Requires any two of the following signs and symptoms both present and new to the patient: temperature >38.3°C or <36.0°C; heart rate >90 beat min−1; respiratory rate >20 bpm; acutely altered mental status; leucocytosis—WBC >12 000 μl−1; leucopaenia—WBC <4000 μl−1; hyperglycaemia (plasma glucose >7.7 mmol litre-1) in the absence of diabetes; plasma C-reactive protein >2 sd above the normal value |
| Sepsis | The clinical syndrome defined by the presence of both signs and symptoms of infection as described above and documented or suspected new infection |
| Severe sepsis | Sepsis complicated by one organ dysfunction |
| Multi-organ failure | Two or more organ dysfunction |
| Organ dysfunction | Defined using the definitions used for the Sequential Organ Failure Assessment (SOFA) score:40Pao2/Fio2≤26.7 kPa; noradrenaline/adrenaline ≥0.1 μg kg−1 min−1; creatinine ≥330 μmol litre−1; platelets ≤50×103 ml−1; bilirubin ≥102 μmol litre−1; Glasgow Coma Score <9 |
| Septic shock | In adults applies to a state of acute circulatory failure unexplained by other causes, defined as persistent arterial hypotension [a systolic arterial pressure (SBP) <90, MAP<60, or a reduction in SBP 40 mm Hg from baseline despite adequate volume resuscitation] |
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