Examples of drugs, which could be shown to bind to targets unknown so far and have similar binding sites in the already known and the new found target
| Drug name . | Known target . | New target . | Indication (possible) . |
|---|---|---|---|
| Eflornithine | Ornithine decarboxylase (Homo sapiens) | Ornithine decarboxylase (Trypanosoma brucei) [34] | Sleeping sickness |
| Celecoxib | Cyclo oxygenase-2 | Carbonic anhydrase [17] | Glaucoma/cancer |
| Staurosporine | Pim-1 kinase | Synapsin I [16] | – |
| Entacapone | Catechol-O-methyltransferase | Enoyl–acyl carrier protein reductase [76] | Tuberculosis |
| 4,5-dihydroxy-3- (1-naphthyldiazenyl)-2,7- naphthalenedisulfonic acid | RNA editing ligase 1 (T. brucei) | Mitochondrial 2-enoyl thioester reductase (H. Sapiens) [73] | – |
| UDP-galactose 4′ epimerase (T. brucei) [73] | Sleeping sickness | ||
| Ibuprofen | Phospholipase A2 | Porcine pancreatic elastase [78] | – |
| Drug name . | Known target . | New target . | Indication (possible) . |
|---|---|---|---|
| Eflornithine | Ornithine decarboxylase (Homo sapiens) | Ornithine decarboxylase (Trypanosoma brucei) [34] | Sleeping sickness |
| Celecoxib | Cyclo oxygenase-2 | Carbonic anhydrase [17] | Glaucoma/cancer |
| Staurosporine | Pim-1 kinase | Synapsin I [16] | – |
| Entacapone | Catechol-O-methyltransferase | Enoyl–acyl carrier protein reductase [76] | Tuberculosis |
| 4,5-dihydroxy-3- (1-naphthyldiazenyl)-2,7- naphthalenedisulfonic acid | RNA editing ligase 1 (T. brucei) | Mitochondrial 2-enoyl thioester reductase (H. Sapiens) [73] | – |
| UDP-galactose 4′ epimerase (T. brucei) [73] | Sleeping sickness | ||
| Ibuprofen | Phospholipase A2 | Porcine pancreatic elastase [78] | – |
A possible disease application is given if known.
Examples of drugs, which could be shown to bind to targets unknown so far and have similar binding sites in the already known and the new found target
| Drug name . | Known target . | New target . | Indication (possible) . |
|---|---|---|---|
| Eflornithine | Ornithine decarboxylase (Homo sapiens) | Ornithine decarboxylase (Trypanosoma brucei) [34] | Sleeping sickness |
| Celecoxib | Cyclo oxygenase-2 | Carbonic anhydrase [17] | Glaucoma/cancer |
| Staurosporine | Pim-1 kinase | Synapsin I [16] | – |
| Entacapone | Catechol-O-methyltransferase | Enoyl–acyl carrier protein reductase [76] | Tuberculosis |
| 4,5-dihydroxy-3- (1-naphthyldiazenyl)-2,7- naphthalenedisulfonic acid | RNA editing ligase 1 (T. brucei) | Mitochondrial 2-enoyl thioester reductase (H. Sapiens) [73] | – |
| UDP-galactose 4′ epimerase (T. brucei) [73] | Sleeping sickness | ||
| Ibuprofen | Phospholipase A2 | Porcine pancreatic elastase [78] | – |
| Drug name . | Known target . | New target . | Indication (possible) . |
|---|---|---|---|
| Eflornithine | Ornithine decarboxylase (Homo sapiens) | Ornithine decarboxylase (Trypanosoma brucei) [34] | Sleeping sickness |
| Celecoxib | Cyclo oxygenase-2 | Carbonic anhydrase [17] | Glaucoma/cancer |
| Staurosporine | Pim-1 kinase | Synapsin I [16] | – |
| Entacapone | Catechol-O-methyltransferase | Enoyl–acyl carrier protein reductase [76] | Tuberculosis |
| 4,5-dihydroxy-3- (1-naphthyldiazenyl)-2,7- naphthalenedisulfonic acid | RNA editing ligase 1 (T. brucei) | Mitochondrial 2-enoyl thioester reductase (H. Sapiens) [73] | – |
| UDP-galactose 4′ epimerase (T. brucei) [73] | Sleeping sickness | ||
| Ibuprofen | Phospholipase A2 | Porcine pancreatic elastase [78] | – |
A possible disease application is given if known.
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