Examples of the usage of binding site comparison tools to identify new drug targets
| Name . | Purpose . | Targets . | Validated . | URL . |
|---|---|---|---|---|
| SiteAlign [64] | New target of staurosporine [16]. | 134 | 1 | bioinfo-pharma.u-strasbg.fr |
| SOIPPA [72] | Targets of entacapone and tolcapone [76]. | – | 1 | funsite.sdsc.edu |
| Off-targets of cholesteryl ester transfer protein inhibitors [77]. | 204 | – | ||
| Alternative targets [73]. | 87 | 2 | ||
| Minai et al. [78] | Alternative targets [78]. | 540 | 1 |
| Name . | Purpose . | Targets . | Validated . | URL . |
|---|---|---|---|---|
| SiteAlign [64] | New target of staurosporine [16]. | 134 | 1 | bioinfo-pharma.u-strasbg.fr |
| SOIPPA [72] | Targets of entacapone and tolcapone [76]. | – | 1 | funsite.sdsc.edu |
| Off-targets of cholesteryl ester transfer protein inhibitors [77]. | 204 | – | ||
| Alternative targets [73]. | 87 | 2 | ||
| Minai et al. [78] | Alternative targets [78]. | 540 | 1 |
The table lists the name of the tools together with the number of proposed new targets and the number of experimentally validated targets.
Examples of the usage of binding site comparison tools to identify new drug targets
| Name . | Purpose . | Targets . | Validated . | URL . |
|---|---|---|---|---|
| SiteAlign [64] | New target of staurosporine [16]. | 134 | 1 | bioinfo-pharma.u-strasbg.fr |
| SOIPPA [72] | Targets of entacapone and tolcapone [76]. | – | 1 | funsite.sdsc.edu |
| Off-targets of cholesteryl ester transfer protein inhibitors [77]. | 204 | – | ||
| Alternative targets [73]. | 87 | 2 | ||
| Minai et al. [78] | Alternative targets [78]. | 540 | 1 |
| Name . | Purpose . | Targets . | Validated . | URL . |
|---|---|---|---|---|
| SiteAlign [64] | New target of staurosporine [16]. | 134 | 1 | bioinfo-pharma.u-strasbg.fr |
| SOIPPA [72] | Targets of entacapone and tolcapone [76]. | – | 1 | funsite.sdsc.edu |
| Off-targets of cholesteryl ester transfer protein inhibitors [77]. | 204 | – | ||
| Alternative targets [73]. | 87 | 2 | ||
| Minai et al. [78] | Alternative targets [78]. | 540 | 1 |
The table lists the name of the tools together with the number of proposed new targets and the number of experimentally validated targets.
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