Switches from PS to iPS (LMP7/β5, LMP2/β1, MECL-1/β2), TLR and CD46 mRNA expressions in peripheral WBCs and PSMB8/PSMB9 SNP rs9357155 genotype alleles
| Variable . | Non-fast progressors (n = 117) . | Fast progressors (n = 40) . | P-value . |
|---|---|---|---|
| LMP7/β5 | 1.58 (1.28–2.09) | 1.87 (1.38–2.94) | 0.04 |
| LMP2/β1 | 1.18 (0.94–1.73) | 1.6 (1–5.55) | 0.04 |
| MECL-1/β2 | 0.85 (0.64–1.17) | 0.79 (0.6–1.34) | 0.83 |
| TLR2mRNA | 1.19 (0.8–1.89) | 1.56 (0.86–3.53) | 0.12 |
| TLR4mRNA | 1.34 (0.85–1.95) | 1.3 (0.89–3.01) | 0.45 |
| CD46 mRNAlog | −0.13 (−0.58 to 0.29) | −0.55 (−1.07 to 0.01) | 0.007 |
|
|
| 0.74 |
| Variable . | Non-fast progressors (n = 117) . | Fast progressors (n = 40) . | P-value . |
|---|---|---|---|
| LMP7/β5 | 1.58 (1.28–2.09) | 1.87 (1.38–2.94) | 0.04 |
| LMP2/β1 | 1.18 (0.94–1.73) | 1.6 (1–5.55) | 0.04 |
| MECL-1/β2 | 0.85 (0.64–1.17) | 0.79 (0.6–1.34) | 0.83 |
| TLR2mRNA | 1.19 (0.8–1.89) | 1.56 (0.86–3.53) | 0.12 |
| TLR4mRNA | 1.34 (0.85–1.95) | 1.3 (0.89–3.01) | 0.45 |
| CD46 mRNAlog | −0.13 (−0.58 to 0.29) | −0.55 (−1.07 to 0.01) | 0.007 |
|
|
| 0.74 |
LMP7/β5, LMP2/β1, MECL-1/β2 are expressed as a ratio of mRNA expressions and TLR2 and TLR mRNA expressions as arbitrary units. CD46 mRNA expression is reported in log U (details in the Methods section). rs9357155 SNP genotypes at the PSMB8/PSMB9 locus are expressed as the frequency of the alleles.
Switches from PS to iPS (LMP7/β5, LMP2/β1, MECL-1/β2), TLR and CD46 mRNA expressions in peripheral WBCs and PSMB8/PSMB9 SNP rs9357155 genotype alleles
| Variable . | Non-fast progressors (n = 117) . | Fast progressors (n = 40) . | P-value . |
|---|---|---|---|
| LMP7/β5 | 1.58 (1.28–2.09) | 1.87 (1.38–2.94) | 0.04 |
| LMP2/β1 | 1.18 (0.94–1.73) | 1.6 (1–5.55) | 0.04 |
| MECL-1/β2 | 0.85 (0.64–1.17) | 0.79 (0.6–1.34) | 0.83 |
| TLR2mRNA | 1.19 (0.8–1.89) | 1.56 (0.86–3.53) | 0.12 |
| TLR4mRNA | 1.34 (0.85–1.95) | 1.3 (0.89–3.01) | 0.45 |
| CD46 mRNAlog | −0.13 (−0.58 to 0.29) | −0.55 (−1.07 to 0.01) | 0.007 |
|
|
| 0.74 |
| Variable . | Non-fast progressors (n = 117) . | Fast progressors (n = 40) . | P-value . |
|---|---|---|---|
| LMP7/β5 | 1.58 (1.28–2.09) | 1.87 (1.38–2.94) | 0.04 |
| LMP2/β1 | 1.18 (0.94–1.73) | 1.6 (1–5.55) | 0.04 |
| MECL-1/β2 | 0.85 (0.64–1.17) | 0.79 (0.6–1.34) | 0.83 |
| TLR2mRNA | 1.19 (0.8–1.89) | 1.56 (0.86–3.53) | 0.12 |
| TLR4mRNA | 1.34 (0.85–1.95) | 1.3 (0.89–3.01) | 0.45 |
| CD46 mRNAlog | −0.13 (−0.58 to 0.29) | −0.55 (−1.07 to 0.01) | 0.007 |
|
|
| 0.74 |
LMP7/β5, LMP2/β1, MECL-1/β2 are expressed as a ratio of mRNA expressions and TLR2 and TLR mRNA expressions as arbitrary units. CD46 mRNA expression is reported in log U (details in the Methods section). rs9357155 SNP genotypes at the PSMB8/PSMB9 locus are expressed as the frequency of the alleles.
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
