Table 3.

Microbiologic Data and Its Relationship to 90-Day Mortalitya

CharacteristicSurvived
(n = 235)
Died
(n = 80)
Total
(N = 315)
Odds Ratio
(95% CI)
P Value
Positive blood culture prior to antimicrobials80 (34.0)22 (27.5)102 (32.4)0.66 (.37–1.20).18
Positive blood culture after antibiotics47 (20.0)16 (20.0)63 (20.0)0.79 (.40–1.57).51
Any positive blood culture83 (35.3)23 (28.8)106 (33.6)0.65 (.36–1.18).16
Concordant blood cultures44 (18.7)15 (18.8)59 (18.7)0.81 (.40–1.63).56
Pathogen recovered80 (34.0)22 (27.8)102 (32.3)1.07 (.89–1.29).51
Source of infection235 (100)80 (100)315 (100)0.99 (.83–1.17).88
Time to positivity of preantibiotic blood culture, h, median (IQR) (n = 100)n = 79
14.0 (12–17)
n = 21
12.0 (10–17)
13.0 (11–17)1.02 (.93–1.12).69
Time to positivity of postantibiotic blood culture, h, median (IQR) (n = 60)n = 44
17.5 (14–29)
n = 16
15.5 (11–23)
17.0 (13–24)0.96 (.91–1.02).18
CharacteristicSurvived
(n = 235)
Died
(n = 80)
Total
(N = 315)
Odds Ratio
(95% CI)
P Value
Positive blood culture prior to antimicrobials80 (34.0)22 (27.5)102 (32.4)0.66 (.37–1.20).18
Positive blood culture after antibiotics47 (20.0)16 (20.0)63 (20.0)0.79 (.40–1.57).51
Any positive blood culture83 (35.3)23 (28.8)106 (33.6)0.65 (.36–1.18).16
Concordant blood cultures44 (18.7)15 (18.8)59 (18.7)0.81 (.40–1.63).56
Pathogen recovered80 (34.0)22 (27.8)102 (32.3)1.07 (.89–1.29).51
Source of infection235 (100)80 (100)315 (100)0.99 (.83–1.17).88
Time to positivity of preantibiotic blood culture, h, median (IQR) (n = 100)n = 79
14.0 (12–17)
n = 21
12.0 (10–17)
13.0 (11–17)1.02 (.93–1.12).69
Time to positivity of postantibiotic blood culture, h, median (IQR) (n = 60)n = 44
17.5 (14–29)
n = 16
15.5 (11–23)
17.0 (13–24)0.96 (.91–1.02).18

Data are presented as No. (%) unless otherwise indicated.

Abbreviations: CI, confidence interval; IQR, interquartile range.

aMultivariate model adjusting for age, Charlson Comorbidity Index, the presence of malignancy, a positive quick Sequential Organ Failure Assessment score, an abnormal white blood cell count, and male sex.

Table 3.

Microbiologic Data and Its Relationship to 90-Day Mortalitya

CharacteristicSurvived
(n = 235)
Died
(n = 80)
Total
(N = 315)
Odds Ratio
(95% CI)
P Value
Positive blood culture prior to antimicrobials80 (34.0)22 (27.5)102 (32.4)0.66 (.37–1.20).18
Positive blood culture after antibiotics47 (20.0)16 (20.0)63 (20.0)0.79 (.40–1.57).51
Any positive blood culture83 (35.3)23 (28.8)106 (33.6)0.65 (.36–1.18).16
Concordant blood cultures44 (18.7)15 (18.8)59 (18.7)0.81 (.40–1.63).56
Pathogen recovered80 (34.0)22 (27.8)102 (32.3)1.07 (.89–1.29).51
Source of infection235 (100)80 (100)315 (100)0.99 (.83–1.17).88
Time to positivity of preantibiotic blood culture, h, median (IQR) (n = 100)n = 79
14.0 (12–17)
n = 21
12.0 (10–17)
13.0 (11–17)1.02 (.93–1.12).69
Time to positivity of postantibiotic blood culture, h, median (IQR) (n = 60)n = 44
17.5 (14–29)
n = 16
15.5 (11–23)
17.0 (13–24)0.96 (.91–1.02).18
CharacteristicSurvived
(n = 235)
Died
(n = 80)
Total
(N = 315)
Odds Ratio
(95% CI)
P Value
Positive blood culture prior to antimicrobials80 (34.0)22 (27.5)102 (32.4)0.66 (.37–1.20).18
Positive blood culture after antibiotics47 (20.0)16 (20.0)63 (20.0)0.79 (.40–1.57).51
Any positive blood culture83 (35.3)23 (28.8)106 (33.6)0.65 (.36–1.18).16
Concordant blood cultures44 (18.7)15 (18.8)59 (18.7)0.81 (.40–1.63).56
Pathogen recovered80 (34.0)22 (27.8)102 (32.3)1.07 (.89–1.29).51
Source of infection235 (100)80 (100)315 (100)0.99 (.83–1.17).88
Time to positivity of preantibiotic blood culture, h, median (IQR) (n = 100)n = 79
14.0 (12–17)
n = 21
12.0 (10–17)
13.0 (11–17)1.02 (.93–1.12).69
Time to positivity of postantibiotic blood culture, h, median (IQR) (n = 60)n = 44
17.5 (14–29)
n = 16
15.5 (11–23)
17.0 (13–24)0.96 (.91–1.02).18

Data are presented as No. (%) unless otherwise indicated.

Abbreviations: CI, confidence interval; IQR, interquartile range.

aMultivariate model adjusting for age, Charlson Comorbidity Index, the presence of malignancy, a positive quick Sequential Organ Failure Assessment score, an abnormal white blood cell count, and male sex.

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