Table 3 Open in new tab Univariable...

	MACE	All-cause mortality
Age	1.02 (0.95–1.09)	0.59	2.93 (0.95–3.50)	0.26
Male	2.55 (1.50–2.42)	<0.001	1.91 (1.34–2.73)	<0.0001
Hypertension	1.09 (0.65–1.82)	0.77	1.26 (0.86–1.85)	0.24
Diabetes mellitus	1.19 (0.67–2.13)	0.56	0.91 (0.60–1.36)	0.64
Hypercholesterolaemia	1.01 (0.62–1.64)	0.98	0.80 (0.56–1.14)	0.22
Smoking	1.07 (0.56–2.18)	0.88	0.95 (0.44–2.06)	0.90
Family history of CAD	1.25 (0.69–2.26)	0.46	1.52 (0.51–4.45)	0.46
Renal failure^a	1.49 (0.20–10.80)	0.69	1.49 (0.27–8.22)	0.64
Presence of LGE^b	5.04 (3.01–8.45)	<0.001	2.37 (1.43–3.93)	0.001
Presence of LGE with viability	2.32 (1.78–3.02)	<0.001	1.97 (1.14–3.38)	0.013
Presence of inducible ischaemia	3.33 (2.24–4.95)	<0.001	1.93 (1.38–1.69)	<0.001
Number of segments with inducible ischaemia	2.31 (1.38––3.91)	<0.001	1.21 (1.08–1.34)	<0.001
LV ejection fraction	1.19 (0.93–1.54)	0.18	1.20 (0.38–1.67)	0.22
RV ejection fraction	1.23 (0.79–2.51)	0.40	1.08 (0.29–1.58)	0.78

MACE

All-cause mortality

Hazard ratio (95% CI)

P value

Hazard ratio (95% CI)

P value

Age

1.02 (0.95–1.09)

0.59

2.93 (0.95–3.50)

0.26

Male

2.55 (1.50–2.42)

<0.001

1.91 (1.34–2.73)

<0.0001

Hypertension

1.09 (0.65–1.82)

0.77

1.26 (0.86–1.85)

0.24

Diabetes mellitus

1.19 (0.67–2.13)

0.56

0.91 (0.60–1.36)

0.64

Hypercholesterolaemia

1.01 (0.62–1.64)

0.98

0.80 (0.56–1.14)

0.22

Smoking

1.07 (0.56–2.18)

0.88

0.95 (0.44–2.06)

0.90

Family history of CAD

1.25 (0.69–2.26)

0.46

1.52 (0.51–4.45)

0.46

Renal failure^a

1.49 (0.20–10.80)

0.69

1.49 (0.27–8.22)

0.64

Presence of LGE^b

5.04 (3.01–8.45)

<0.001

2.37 (1.43–3.93)

0.001

Presence of LGE with viability

2.32 (1.78–3.02)

<0.001

1.97 (1.14–3.38)

0.013

Presence of inducible ischaemia

3.33 (2.24–4.95)

<0.001

1.93 (1.38–1.69)

<0.001

Number of segments with inducible ischaemia

2.31 (1.38––3.91)

<0.001

1.21 (1.08–1.34)

<0.001

LV ejection fraction

1.19 (0.93–1.54)

0.18

1.20 (0.38–1.67)

0.22

RV ejection fraction

1.23 (0.79–2.51)

0.40

1.08 (0.29–1.58)

0.78

	MACE	All-cause mortality
Age	1.02 (0.95–1.09)	0.59	2.93 (0.95–3.50)	0.26
Male	2.55 (1.50–2.42)	<0.001	1.91 (1.34–2.73)	<0.0001
Hypertension	1.09 (0.65–1.82)	0.77	1.26 (0.86–1.85)	0.24
Diabetes mellitus	1.19 (0.67–2.13)	0.56	0.91 (0.60–1.36)	0.64
Hypercholesterolaemia	1.01 (0.62–1.64)	0.98	0.80 (0.56–1.14)	0.22
Smoking	1.07 (0.56–2.18)	0.88	0.95 (0.44–2.06)	0.90
Family history of CAD	1.25 (0.69–2.26)	0.46	1.52 (0.51–4.45)	0.46
Renal failure^a	1.49 (0.20–10.80)	0.69	1.49 (0.27–8.22)	0.64
Presence of LGE^b	5.04 (3.01–8.45)	<0.001	2.37 (1.43–3.93)	0.001
Presence of LGE with viability	2.32 (1.78–3.02)	<0.001	1.97 (1.14–3.38)	0.013
Presence of inducible ischaemia	3.33 (2.24–4.95)	<0.001	1.93 (1.38–1.69)	<0.001
Number of segments with inducible ischaemia	2.31 (1.38––3.91)	<0.001	1.21 (1.08–1.34)	<0.001
LV ejection fraction	1.19 (0.93–1.54)	0.18	1.20 (0.38–1.67)	0.22
RV ejection fraction	1.23 (0.79–2.51)	0.40	1.08 (0.29–1.58)	0.78

Table 3

Open in new tab

Univariable analysis of clinical and CMR characteristics for prediction of adverse events

	MACE		All-cause mortality
	Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)	P value
Age	1.02 (0.95–1.09)	0.59	2.93 (0.95–3.50)	0.26
Male	2.55 (1.50–2.42)	<0.001	1.91 (1.34–2.73)	<0.0001
Hypertension	1.09 (0.65–1.82)	0.77	1.26 (0.86–1.85)	0.24
Diabetes mellitus	1.19 (0.67–2.13)	0.56	0.91 (0.60–1.36)	0.64
Hypercholesterolaemia	1.01 (0.62–1.64)	0.98	0.80 (0.56–1.14)	0.22
Smoking	1.07 (0.56–2.18)	0.88	0.95 (0.44–2.06)	0.90
Family history of CAD	1.25 (0.69–2.26)	0.46	1.52 (0.51–4.45)	0.46
Renal failure^a	1.49 (0.20–10.80)	0.69	1.49 (0.27–8.22)	0.64
Presence of LGE^b	5.04 (3.01–8.45)	<0.001	2.37 (1.43–3.93)	0.001
Presence of LGE with viability	2.32 (1.78–3.02)	<0.001	1.97 (1.14–3.38)	0.013
Presence of inducible ischaemia	3.33 (2.24–4.95)	<0.001	1.93 (1.38–1.69)	<0.001
Number of segments with inducible ischaemia	2.31 (1.38––3.91)	<0.001	1.21 (1.08–1.34)	<0.001
LV ejection fraction	1.19 (0.93–1.54)	0.18	1.20 (0.38–1.67)	0.22
RV ejection fraction	1.23 (0.79–2.51)	0.40	1.08 (0.29–1.58)	0.78

	MACE		All-cause mortality
	Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)	P value
Age	1.02 (0.95–1.09)	0.59	2.93 (0.95–3.50)	0.26
Male	2.55 (1.50–2.42)	<0.001	1.91 (1.34–2.73)	<0.0001
Hypertension	1.09 (0.65–1.82)	0.77	1.26 (0.86–1.85)	0.24
Diabetes mellitus	1.19 (0.67–2.13)	0.56	0.91 (0.60–1.36)	0.64
Hypercholesterolaemia	1.01 (0.62–1.64)	0.98	0.80 (0.56–1.14)	0.22
Smoking	1.07 (0.56–2.18)	0.88	0.95 (0.44–2.06)	0.90
Family history of CAD	1.25 (0.69–2.26)	0.46	1.52 (0.51–4.45)	0.46
Renal failure^a	1.49 (0.20–10.80)	0.69	1.49 (0.27–8.22)	0.64
Presence of LGE^b	5.04 (3.01–8.45)	<0.001	2.37 (1.43–3.93)	0.001
Presence of LGE with viability	2.32 (1.78–3.02)	<0.001	1.97 (1.14–3.38)	0.013
Presence of inducible ischaemia	3.33 (2.24–4.95)	<0.001	1.93 (1.38–1.69)	<0.001
Number of segments with inducible ischaemia	2.31 (1.38––3.91)	<0.001	1.21 (1.08–1.34)	<0.001
LV ejection fraction	1.19 (0.93–1.54)	0.18	1.20 (0.38–1.67)	0.22
RV ejection fraction	1.23 (0.79–2.51)	0.40	1.08 (0.29–1.58)	0.78

BMI, body mass index; CI, confidence interval; CMR, cardiovascular magnetic resonance; LGE, late gadolinium enhancement; LV, left ventricular; MACE, major adverse cardiovascular events; RV, right ventricular.

Defined by glomerular filtration rate (GFR) = 30–90 mL/min.

Per 10 units increment.

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