ROC curves analysis of SLEDAI-2000 index to determine the most appropriate minimal decrease in score associated with no increase in therapy
| Decrease in SLEDAI-2000 score (magnitude) . | Sensitivity % (95% CI) . | Specificity % (95% CI) . | PPV % (95% CI) . | NPV % (95% CI) . | Youden index . |
|---|---|---|---|---|---|
| ≥1 | 31.7 (28.9, 34.6) | 80.7 (76.3, 84.4) | 84.8 (81.1, 87.9) | 25.7 (22.8, 29.0) | 0.12 |
| ≥2 | 30.2 (27.5, 33.2) | 81.9 (77.6, 85.6) | 85.1 (81.2, 88.3) | 25.7 (22.7, 28.8) | 0.12 |
| ≥3 | 16.0 (13.8, 18.5) | 91.6 (88.1, 94.1) | 86.6 (81.4, 90.6) | 24.3 (21.6, 27.1) | 0.08 |
| ≥4 | 14.9 (12.7, 17.4) | 93.1 (90.0, 95.4) | 88.1 (82.8, 91.9) | 24.3 (21.7, 27.2) | 0.08 |
| ≥5 | 7.2 (5.7, 9.2) | 96.6 (94.1, 98.0) | 87.8 (80.1, 92.8) | 23.4 (20.9, 26.1) | 0.04 |
| ≥6 | 7.0 (5.5, 9.0) | 97.2 (94.8, 98.5) | 89.5 (81.8, 94.2) | 23.5 (21.0, 26.2) | 0.04 |
| ≥7 | 4.7 (3.4, 6.4) | 98.1 (96.0, 99.1) | 89.5 (79.7, 94.8) | 23.2 (20.8, 25.8) | 0.03 |
| Decrease in SLEDAI-2000 score (magnitude) . | Sensitivity % (95% CI) . | Specificity % (95% CI) . | PPV % (95% CI) . | NPV % (95% CI) . | Youden index . |
|---|---|---|---|---|---|
| ≥1 | 31.7 (28.9, 34.6) | 80.7 (76.3, 84.4) | 84.8 (81.1, 87.9) | 25.7 (22.8, 29.0) | 0.12 |
| ≥2 | 30.2 (27.5, 33.2) | 81.9 (77.6, 85.6) | 85.1 (81.2, 88.3) | 25.7 (22.7, 28.8) | 0.12 |
| ≥3 | 16.0 (13.8, 18.5) | 91.6 (88.1, 94.1) | 86.6 (81.4, 90.6) | 24.3 (21.6, 27.1) | 0.08 |
| ≥4 | 14.9 (12.7, 17.4) | 93.1 (90.0, 95.4) | 88.1 (82.8, 91.9) | 24.3 (21.7, 27.2) | 0.08 |
| ≥5 | 7.2 (5.7, 9.2) | 96.6 (94.1, 98.0) | 87.8 (80.1, 92.8) | 23.4 (20.9, 26.1) | 0.04 |
| ≥6 | 7.0 (5.5, 9.0) | 97.2 (94.8, 98.5) | 89.5 (81.8, 94.2) | 23.5 (21.0, 26.2) | 0.04 |
| ≥7 | 4.7 (3.4, 6.4) | 98.1 (96.0, 99.1) | 89.5 (79.7, 94.8) | 23.2 (20.8, 25.8) | 0.03 |
ROC curves analysis of SLEDAI-2000 index to determine the most appropriate minimal decrease in score associated with no increase in therapy
| Decrease in SLEDAI-2000 score (magnitude) . | Sensitivity % (95% CI) . | Specificity % (95% CI) . | PPV % (95% CI) . | NPV % (95% CI) . | Youden index . |
|---|---|---|---|---|---|
| ≥1 | 31.7 (28.9, 34.6) | 80.7 (76.3, 84.4) | 84.8 (81.1, 87.9) | 25.7 (22.8, 29.0) | 0.12 |
| ≥2 | 30.2 (27.5, 33.2) | 81.9 (77.6, 85.6) | 85.1 (81.2, 88.3) | 25.7 (22.7, 28.8) | 0.12 |
| ≥3 | 16.0 (13.8, 18.5) | 91.6 (88.1, 94.1) | 86.6 (81.4, 90.6) | 24.3 (21.6, 27.1) | 0.08 |
| ≥4 | 14.9 (12.7, 17.4) | 93.1 (90.0, 95.4) | 88.1 (82.8, 91.9) | 24.3 (21.7, 27.2) | 0.08 |
| ≥5 | 7.2 (5.7, 9.2) | 96.6 (94.1, 98.0) | 87.8 (80.1, 92.8) | 23.4 (20.9, 26.1) | 0.04 |
| ≥6 | 7.0 (5.5, 9.0) | 97.2 (94.8, 98.5) | 89.5 (81.8, 94.2) | 23.5 (21.0, 26.2) | 0.04 |
| ≥7 | 4.7 (3.4, 6.4) | 98.1 (96.0, 99.1) | 89.5 (79.7, 94.8) | 23.2 (20.8, 25.8) | 0.03 |
| Decrease in SLEDAI-2000 score (magnitude) . | Sensitivity % (95% CI) . | Specificity % (95% CI) . | PPV % (95% CI) . | NPV % (95% CI) . | Youden index . |
|---|---|---|---|---|---|
| ≥1 | 31.7 (28.9, 34.6) | 80.7 (76.3, 84.4) | 84.8 (81.1, 87.9) | 25.7 (22.8, 29.0) | 0.12 |
| ≥2 | 30.2 (27.5, 33.2) | 81.9 (77.6, 85.6) | 85.1 (81.2, 88.3) | 25.7 (22.7, 28.8) | 0.12 |
| ≥3 | 16.0 (13.8, 18.5) | 91.6 (88.1, 94.1) | 86.6 (81.4, 90.6) | 24.3 (21.6, 27.1) | 0.08 |
| ≥4 | 14.9 (12.7, 17.4) | 93.1 (90.0, 95.4) | 88.1 (82.8, 91.9) | 24.3 (21.7, 27.2) | 0.08 |
| ≥5 | 7.2 (5.7, 9.2) | 96.6 (94.1, 98.0) | 87.8 (80.1, 92.8) | 23.4 (20.9, 26.1) | 0.04 |
| ≥6 | 7.0 (5.5, 9.0) | 97.2 (94.8, 98.5) | 89.5 (81.8, 94.2) | 23.5 (21.0, 26.2) | 0.04 |
| ≥7 | 4.7 (3.4, 6.4) | 98.1 (96.0, 99.1) | 89.5 (79.7, 94.8) | 23.2 (20.8, 25.8) | 0.03 |
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