| . | HC . | MS patients . | p-value . | p-value FDR . |
|---|---|---|---|---|
| Force-matching performance | ||||
| Number of participants | 17 | 28 | ||
| Upper limb lag, ms | 184.71 (113.75) | 216.07 (90.08) | 0.201 | 0.503 |
| Upper limb force error, N | 0.31 (0.07) | 0.34 (0.09) | 0.226 | 0.452 |
| Lower limb lag, ms | 142.35 (116.49) | 266.43 (120.68) | 0.002* | 0.010* |
| Lower limb force error, N | 0.30 (0.05) | 0.45 (0.16) | 0.001* | 0.010* |
| Spatiotemporal gait measures | ||||
| Number of participants | 15 | 28 | ||
| Speed, ms | 1.39 (0.04) | 1.38 (0.03) | 0.308 | 0.513 |
| Single support, % gait cycle | 40.19 (3.26) | 40.45 (2.92) | 0.760 | 1.000 |
| Terminal double support, % gait cycle | 7.79 (1.30) | 7.78 (1.54) | 0.985 | 0.985 |
| Stance, % gait cycle | 58.52 (1.26) | 58.44 (2.35) | 0.899 | 1.000 |
| Stride length, mm | 1426.26 (88.09) | 1358.05 (89.16) | 0.021* | 0.070 |
| Step width, mm | 75.51 (22.68) | 77.26 (24.50) | 0.919 | 1.000 |
| . | HC . | MS patients . | p-value . | p-value FDR . |
|---|---|---|---|---|
| Force-matching performance | ||||
| Number of participants | 17 | 28 | ||
| Upper limb lag, ms | 184.71 (113.75) | 216.07 (90.08) | 0.201 | 0.503 |
| Upper limb force error, N | 0.31 (0.07) | 0.34 (0.09) | 0.226 | 0.452 |
| Lower limb lag, ms | 142.35 (116.49) | 266.43 (120.68) | 0.002* | 0.010* |
| Lower limb force error, N | 0.30 (0.05) | 0.45 (0.16) | 0.001* | 0.010* |
| Spatiotemporal gait measures | ||||
| Number of participants | 15 | 28 | ||
| Speed, ms | 1.39 (0.04) | 1.38 (0.03) | 0.308 | 0.513 |
| Single support, % gait cycle | 40.19 (3.26) | 40.45 (2.92) | 0.760 | 1.000 |
| Terminal double support, % gait cycle | 7.79 (1.30) | 7.78 (1.54) | 0.985 | 0.985 |
| Stance, % gait cycle | 58.52 (1.26) | 58.44 (2.35) | 0.899 | 1.000 |
| Stride length, mm | 1426.26 (88.09) | 1358.05 (89.16) | 0.021* | 0.070 |
| Step width, mm | 75.51 (22.68) | 77.26 (24.50) | 0.919 | 1.000 |
Compared to HC, MS patients showed worse behavioural performance during the lower limb visually guided motor task during fMRI testing, but no differences were observed during upper limb movement. MS patients displayed longer lag (p = 0.002) and more force error (p = 0.001) during lower limb movements, compared to HC. In addition, during walking patients showed a shorter stride length compared to controls (p= 0.021). *Significant difference between MS patients and HC.
| . | HC . | MS patients . | p-value . | p-value FDR . |
|---|---|---|---|---|
| Force-matching performance | ||||
| Number of participants | 17 | 28 | ||
| Upper limb lag, ms | 184.71 (113.75) | 216.07 (90.08) | 0.201 | 0.503 |
| Upper limb force error, N | 0.31 (0.07) | 0.34 (0.09) | 0.226 | 0.452 |
| Lower limb lag, ms | 142.35 (116.49) | 266.43 (120.68) | 0.002* | 0.010* |
| Lower limb force error, N | 0.30 (0.05) | 0.45 (0.16) | 0.001* | 0.010* |
| Spatiotemporal gait measures | ||||
| Number of participants | 15 | 28 | ||
| Speed, ms | 1.39 (0.04) | 1.38 (0.03) | 0.308 | 0.513 |
| Single support, % gait cycle | 40.19 (3.26) | 40.45 (2.92) | 0.760 | 1.000 |
| Terminal double support, % gait cycle | 7.79 (1.30) | 7.78 (1.54) | 0.985 | 0.985 |
| Stance, % gait cycle | 58.52 (1.26) | 58.44 (2.35) | 0.899 | 1.000 |
| Stride length, mm | 1426.26 (88.09) | 1358.05 (89.16) | 0.021* | 0.070 |
| Step width, mm | 75.51 (22.68) | 77.26 (24.50) | 0.919 | 1.000 |
| . | HC . | MS patients . | p-value . | p-value FDR . |
|---|---|---|---|---|
| Force-matching performance | ||||
| Number of participants | 17 | 28 | ||
| Upper limb lag, ms | 184.71 (113.75) | 216.07 (90.08) | 0.201 | 0.503 |
| Upper limb force error, N | 0.31 (0.07) | 0.34 (0.09) | 0.226 | 0.452 |
| Lower limb lag, ms | 142.35 (116.49) | 266.43 (120.68) | 0.002* | 0.010* |
| Lower limb force error, N | 0.30 (0.05) | 0.45 (0.16) | 0.001* | 0.010* |
| Spatiotemporal gait measures | ||||
| Number of participants | 15 | 28 | ||
| Speed, ms | 1.39 (0.04) | 1.38 (0.03) | 0.308 | 0.513 |
| Single support, % gait cycle | 40.19 (3.26) | 40.45 (2.92) | 0.760 | 1.000 |
| Terminal double support, % gait cycle | 7.79 (1.30) | 7.78 (1.54) | 0.985 | 0.985 |
| Stance, % gait cycle | 58.52 (1.26) | 58.44 (2.35) | 0.899 | 1.000 |
| Stride length, mm | 1426.26 (88.09) | 1358.05 (89.16) | 0.021* | 0.070 |
| Step width, mm | 75.51 (22.68) | 77.26 (24.50) | 0.919 | 1.000 |
Compared to HC, MS patients showed worse behavioural performance during the lower limb visually guided motor task during fMRI testing, but no differences were observed during upper limb movement. MS patients displayed longer lag (p = 0.002) and more force error (p = 0.001) during lower limb movements, compared to HC. In addition, during walking patients showed a shorter stride length compared to controls (p= 0.021). *Significant difference between MS patients and HC.
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