Age-Adjusted Incidence Rates, Incidence Rate Ratio, and Prevalence Rate with 95% Confidence Intervals (95% CI) for Primary Higher-grade Brainstem Glioma in Children and Adolescents (age ≤19 years) 2000-2017, CBTRUS (N = 4,486).
| . | Total Patients 2000-2017 (%) . | Ratea . | 95% Confidence Interval (CI) . | Incidence Rate Ratio (95% CI) . | P-value . | Prevalence Rate (95% CI) . |
|---|---|---|---|---|---|---|
| Overall | 4,486 | 0.305 | 0.296-0.314 | – | – | 1.49 (1.40-1.57) |
| Sex | ||||||
| Males | 2,162 (48.2) | 0.288 | 0.276-0.300 | – | – | 1.50 (1.39-1.62) |
| Females | 2,324 (51.8) | 0.324 | 0.311-0.337 | 1.13 (1.06-1.19) | <.001 | 1.47 (1.36-1.59) |
| Race | ||||||
| White | 3,439 (76.7) | 0.234 | 0.226-0.242 | – | – | 1.62 (1.57-1.67) |
| Black | 750 (16.7) | 0.051 | 0.048-0.055 | 0.22 (0.20-0.24) | <.001 | 0.72 (0.66-0.78) |
| Other | 297 (6.6) | 0.020 | 0.018-0.023 | 0.08 (0.07-0.09) | <.001 | 0.99 (0.91-1.08) |
| Ethnicity | ||||||
| Hispanic | 914 (19.7) | 0.283 | 0.265-0.302 | – | – | 0.89 (0.81-0.96) |
| Non-Hispanic | 3,735 (80.3) | 0.325 | 0.315-0.336 | 1.14 (1.06-1.23) | <.001 | 1.60 (1.55-1.65) |
| Age at Diagnosis | ||||||
| <1 year | 80 (1.8) | 0.111 | 0.088-0.138 | – | – | 0.12 (0.04-0.29) |
| 01-04 years | 1,093 (24.4) | 0.381 | 0.359-0.404 | 3.43 (2.73-4.36) | <.001 | 0.58 (0.47-0.71) |
| 05-09 years | 1,843 (41.1) | 0.508 | 0.485-0.531 | 4.56 (3.65-5.78) | <.001 | 1.68 (1.51-1.87) |
| 10-14 years | 944 (21.0) | 0.250 | 0.235-0.267 | 2.25 (1.79-2.86) | <.001 | 1.76 (1.58-1.95) |
| 15-19 years | 526 (11.7) | 0.137 | 0.125-0.149 | 1.23 (0.97-1.57) | .093 | 1.97 (1.78-2.17) |
| Gradeb | ||||||
| Radiographic confirmation onlyc | 3,101 (69.1) | 0.211 | 0.204-0.219 | – | – | – |
| Grade 3 | 171 (3.8) | 0.012 | 0.010-0.013 | 0.055 (0.047-0.064) | <.001 | – |
| Grade 4 | 320 (7.1) | 0.022 | 0.020-0.024 | 0.104 (0.092-0.116) | <.001 | – |
| Unknownd | 894 (19.9) | 0.061 | 0.057-0.065 | 0.288 (0.267-0.310) | <.001 | – |
| . | Total Patients 2000-2017 (%) . | Ratea . | 95% Confidence Interval (CI) . | Incidence Rate Ratio (95% CI) . | P-value . | Prevalence Rate (95% CI) . |
|---|---|---|---|---|---|---|
| Overall | 4,486 | 0.305 | 0.296-0.314 | – | – | 1.49 (1.40-1.57) |
| Sex | ||||||
| Males | 2,162 (48.2) | 0.288 | 0.276-0.300 | – | – | 1.50 (1.39-1.62) |
| Females | 2,324 (51.8) | 0.324 | 0.311-0.337 | 1.13 (1.06-1.19) | <.001 | 1.47 (1.36-1.59) |
| Race | ||||||
| White | 3,439 (76.7) | 0.234 | 0.226-0.242 | – | – | 1.62 (1.57-1.67) |
| Black | 750 (16.7) | 0.051 | 0.048-0.055 | 0.22 (0.20-0.24) | <.001 | 0.72 (0.66-0.78) |
| Other | 297 (6.6) | 0.020 | 0.018-0.023 | 0.08 (0.07-0.09) | <.001 | 0.99 (0.91-1.08) |
| Ethnicity | ||||||
| Hispanic | 914 (19.7) | 0.283 | 0.265-0.302 | – | – | 0.89 (0.81-0.96) |
| Non-Hispanic | 3,735 (80.3) | 0.325 | 0.315-0.336 | 1.14 (1.06-1.23) | <.001 | 1.60 (1.55-1.65) |
| Age at Diagnosis | ||||||
| <1 year | 80 (1.8) | 0.111 | 0.088-0.138 | – | – | 0.12 (0.04-0.29) |
| 01-04 years | 1,093 (24.4) | 0.381 | 0.359-0.404 | 3.43 (2.73-4.36) | <.001 | 0.58 (0.47-0.71) |
| 05-09 years | 1,843 (41.1) | 0.508 | 0.485-0.531 | 4.56 (3.65-5.78) | <.001 | 1.68 (1.51-1.87) |
| 10-14 years | 944 (21.0) | 0.250 | 0.235-0.267 | 2.25 (1.79-2.86) | <.001 | 1.76 (1.58-1.95) |
| 15-19 years | 526 (11.7) | 0.137 | 0.125-0.149 | 1.23 (0.97-1.57) | .093 | 1.97 (1.78-2.17) |
| Gradeb | ||||||
| Radiographic confirmation onlyc | 3,101 (69.1) | 0.211 | 0.204-0.219 | – | – | – |
| Grade 3 | 171 (3.8) | 0.012 | 0.010-0.013 | 0.055 (0.047-0.064) | <.001 | – |
| Grade 4 | 320 (7.1) | 0.022 | 0.020-0.024 | 0.104 (0.092-0.116) | <.001 | – |
| Unknownd | 894 (19.9) | 0.061 | 0.057-0.065 | 0.288 (0.267-0.310) | <.001 | – |
aIncidence and Prevalence rates are per 100,000 and are age-adjusted to the 2000 US standard population.
bPrevalence could not be reliably estimated due to the low sample size.
cIncludes unknown grade patients.
dIncludes histologically confirmed, but unknown WHO grade patients.
Age-Adjusted Incidence Rates, Incidence Rate Ratio, and Prevalence Rate with 95% Confidence Intervals (95% CI) for Primary Higher-grade Brainstem Glioma in Children and Adolescents (age ≤19 years) 2000-2017, CBTRUS (N = 4,486).
| . | Total Patients 2000-2017 (%) . | Ratea . | 95% Confidence Interval (CI) . | Incidence Rate Ratio (95% CI) . | P-value . | Prevalence Rate (95% CI) . |
|---|---|---|---|---|---|---|
| Overall | 4,486 | 0.305 | 0.296-0.314 | – | – | 1.49 (1.40-1.57) |
| Sex | ||||||
| Males | 2,162 (48.2) | 0.288 | 0.276-0.300 | – | – | 1.50 (1.39-1.62) |
| Females | 2,324 (51.8) | 0.324 | 0.311-0.337 | 1.13 (1.06-1.19) | <.001 | 1.47 (1.36-1.59) |
| Race | ||||||
| White | 3,439 (76.7) | 0.234 | 0.226-0.242 | – | – | 1.62 (1.57-1.67) |
| Black | 750 (16.7) | 0.051 | 0.048-0.055 | 0.22 (0.20-0.24) | <.001 | 0.72 (0.66-0.78) |
| Other | 297 (6.6) | 0.020 | 0.018-0.023 | 0.08 (0.07-0.09) | <.001 | 0.99 (0.91-1.08) |
| Ethnicity | ||||||
| Hispanic | 914 (19.7) | 0.283 | 0.265-0.302 | – | – | 0.89 (0.81-0.96) |
| Non-Hispanic | 3,735 (80.3) | 0.325 | 0.315-0.336 | 1.14 (1.06-1.23) | <.001 | 1.60 (1.55-1.65) |
| Age at Diagnosis | ||||||
| <1 year | 80 (1.8) | 0.111 | 0.088-0.138 | – | – | 0.12 (0.04-0.29) |
| 01-04 years | 1,093 (24.4) | 0.381 | 0.359-0.404 | 3.43 (2.73-4.36) | <.001 | 0.58 (0.47-0.71) |
| 05-09 years | 1,843 (41.1) | 0.508 | 0.485-0.531 | 4.56 (3.65-5.78) | <.001 | 1.68 (1.51-1.87) |
| 10-14 years | 944 (21.0) | 0.250 | 0.235-0.267 | 2.25 (1.79-2.86) | <.001 | 1.76 (1.58-1.95) |
| 15-19 years | 526 (11.7) | 0.137 | 0.125-0.149 | 1.23 (0.97-1.57) | .093 | 1.97 (1.78-2.17) |
| Gradeb | ||||||
| Radiographic confirmation onlyc | 3,101 (69.1) | 0.211 | 0.204-0.219 | – | – | – |
| Grade 3 | 171 (3.8) | 0.012 | 0.010-0.013 | 0.055 (0.047-0.064) | <.001 | – |
| Grade 4 | 320 (7.1) | 0.022 | 0.020-0.024 | 0.104 (0.092-0.116) | <.001 | – |
| Unknownd | 894 (19.9) | 0.061 | 0.057-0.065 | 0.288 (0.267-0.310) | <.001 | – |
| . | Total Patients 2000-2017 (%) . | Ratea . | 95% Confidence Interval (CI) . | Incidence Rate Ratio (95% CI) . | P-value . | Prevalence Rate (95% CI) . |
|---|---|---|---|---|---|---|
| Overall | 4,486 | 0.305 | 0.296-0.314 | – | – | 1.49 (1.40-1.57) |
| Sex | ||||||
| Males | 2,162 (48.2) | 0.288 | 0.276-0.300 | – | – | 1.50 (1.39-1.62) |
| Females | 2,324 (51.8) | 0.324 | 0.311-0.337 | 1.13 (1.06-1.19) | <.001 | 1.47 (1.36-1.59) |
| Race | ||||||
| White | 3,439 (76.7) | 0.234 | 0.226-0.242 | – | – | 1.62 (1.57-1.67) |
| Black | 750 (16.7) | 0.051 | 0.048-0.055 | 0.22 (0.20-0.24) | <.001 | 0.72 (0.66-0.78) |
| Other | 297 (6.6) | 0.020 | 0.018-0.023 | 0.08 (0.07-0.09) | <.001 | 0.99 (0.91-1.08) |
| Ethnicity | ||||||
| Hispanic | 914 (19.7) | 0.283 | 0.265-0.302 | – | – | 0.89 (0.81-0.96) |
| Non-Hispanic | 3,735 (80.3) | 0.325 | 0.315-0.336 | 1.14 (1.06-1.23) | <.001 | 1.60 (1.55-1.65) |
| Age at Diagnosis | ||||||
| <1 year | 80 (1.8) | 0.111 | 0.088-0.138 | – | – | 0.12 (0.04-0.29) |
| 01-04 years | 1,093 (24.4) | 0.381 | 0.359-0.404 | 3.43 (2.73-4.36) | <.001 | 0.58 (0.47-0.71) |
| 05-09 years | 1,843 (41.1) | 0.508 | 0.485-0.531 | 4.56 (3.65-5.78) | <.001 | 1.68 (1.51-1.87) |
| 10-14 years | 944 (21.0) | 0.250 | 0.235-0.267 | 2.25 (1.79-2.86) | <.001 | 1.76 (1.58-1.95) |
| 15-19 years | 526 (11.7) | 0.137 | 0.125-0.149 | 1.23 (0.97-1.57) | .093 | 1.97 (1.78-2.17) |
| Gradeb | ||||||
| Radiographic confirmation onlyc | 3,101 (69.1) | 0.211 | 0.204-0.219 | – | – | – |
| Grade 3 | 171 (3.8) | 0.012 | 0.010-0.013 | 0.055 (0.047-0.064) | <.001 | – |
| Grade 4 | 320 (7.1) | 0.022 | 0.020-0.024 | 0.104 (0.092-0.116) | <.001 | – |
| Unknownd | 894 (19.9) | 0.061 | 0.057-0.065 | 0.288 (0.267-0.310) | <.001 | – |
aIncidence and Prevalence rates are per 100,000 and are age-adjusted to the 2000 US standard population.
bPrevalence could not be reliably estimated due to the low sample size.
cIncludes unknown grade patients.
dIncludes histologically confirmed, but unknown WHO grade patients.
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