Incidence of Solicited Systemic Adverse Events During the 21 Days Following Each Vaccination
| Symptom . | Vaccine . | Grade . | Group 1 (n = 20) . | . | Group 2 (n = 20) . | . | Group 3 (n = 20) . | . | Group 4 (n = 20) . | . |
|---|---|---|---|---|---|---|---|---|---|---|
| . | . | . | n (%) . | 95% CI . | n (%) . | 95% CI . | n (%) . | 95% CI . | n (%) . | 95% CI . |
| Abdominal Pain | LAV | Any | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 2 (10.0) | 1.2–31.7 | 0 (0.0) | .0–16.8 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Arthralgia | LAV | Any | 2 (10.0) | 1.2–31.7 | 5 (25.0) | 8.7–49.1 | 2 (10.0) | 1.2–31.7 | 4 (20.0) | 5.7–43.7 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 2 (10.0) | 1.2–31.7 | 0 (0.0) | .0–16.8 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Diarrhea | LAV | Any | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Fatigue | LAV | Any | 3 (15.0) | 3.2–37.9 | 8 (40.0) | 19.1–63.9 | 5 (25.0) | 8.7–49.1 | 5 (25.0) | 8.7–49.1 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 2 (10.0) | 1.2–31.7 | ||
| PIV | Any | 2 (10.0) | 1.2–31.7 | 2 (10.0) | 1.2–31.7 | 3 (15.0) | 3.2–37.9 | 4 (20.0) | 5.7–43.7 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Fever | LAV | Any | 0 (0.0) | .0–16.8 | 5 (25.0) | 8.7–49.1 | 0 (0.0) | .0–16.8 | 5 (25.0) | 8.7–49.1 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Headache | LAV | Any | 3 (15.0) | 3.2–37.9 | 8 (40.0) | 19.1–63.9 | 8 (40.0) | 19.1–63.9 | 6 (30.0) | 11.9–54.3 |
| Grade 3 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | 2 (10.0) | 1.2–31.7 | ||
| PIV | Any | 1 (5.0) | .1–24.9 | 3 (15.0) | 3.2–37.9 | 5 (25.0) | 8.7–49.1 | 3 (15.0) | 3.2–37.9 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Myalgia | LAV | Any | 1 (5.0) | .1–24.9 | 5 (25.0) | 8.7–49.1 | 2 (10.0) | 1.2–31.7 | 6 (30.0) | 11.9–54.3 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 4 (20.0) | 5.7–43.7 | 3 (15.0) | 3.2–37.9 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Nausea | LAV | Any | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | 3 (15.0) | 3.2–37.9 | 1 (5.0) | .1–24.9 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | ||
| Vomiting | LAV | Any | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | ||
| Overall | LAV | Any | 5 (25.0) | 8.7–49.1 | 10 (50.0) | 27.2–72.8 | 8 (40.0) | 19.1–63.9 | 8 (40.0) | 19.1–63.9 |
| Grade 3 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | 4 (20.0) | 5.7–43.7 | ||
| PIV | Any | 2 (10.0) | 1.2–31.7 | 4 (20.0) | 5.7–43.7 | 5 (25.0) | 8.7–49.1 | 8 (40.0) | 19.1–63.9 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 |
| Symptom . | Vaccine . | Grade . | Group 1 (n = 20) . | . | Group 2 (n = 20) . | . | Group 3 (n = 20) . | . | Group 4 (n = 20) . | . |
|---|---|---|---|---|---|---|---|---|---|---|
| . | . | . | n (%) . | 95% CI . | n (%) . | 95% CI . | n (%) . | 95% CI . | n (%) . | 95% CI . |
| Abdominal Pain | LAV | Any | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 2 (10.0) | 1.2–31.7 | 0 (0.0) | .0–16.8 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Arthralgia | LAV | Any | 2 (10.0) | 1.2–31.7 | 5 (25.0) | 8.7–49.1 | 2 (10.0) | 1.2–31.7 | 4 (20.0) | 5.7–43.7 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 2 (10.0) | 1.2–31.7 | 0 (0.0) | .0–16.8 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Diarrhea | LAV | Any | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Fatigue | LAV | Any | 3 (15.0) | 3.2–37.9 | 8 (40.0) | 19.1–63.9 | 5 (25.0) | 8.7–49.1 | 5 (25.0) | 8.7–49.1 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 2 (10.0) | 1.2–31.7 | ||
| PIV | Any | 2 (10.0) | 1.2–31.7 | 2 (10.0) | 1.2–31.7 | 3 (15.0) | 3.2–37.9 | 4 (20.0) | 5.7–43.7 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Fever | LAV | Any | 0 (0.0) | .0–16.8 | 5 (25.0) | 8.7–49.1 | 0 (0.0) | .0–16.8 | 5 (25.0) | 8.7–49.1 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Headache | LAV | Any | 3 (15.0) | 3.2–37.9 | 8 (40.0) | 19.1–63.9 | 8 (40.0) | 19.1–63.9 | 6 (30.0) | 11.9–54.3 |
| Grade 3 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | 2 (10.0) | 1.2–31.7 | ||
| PIV | Any | 1 (5.0) | .1–24.9 | 3 (15.0) | 3.2–37.9 | 5 (25.0) | 8.7–49.1 | 3 (15.0) | 3.2–37.9 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Myalgia | LAV | Any | 1 (5.0) | .1–24.9 | 5 (25.0) | 8.7–49.1 | 2 (10.0) | 1.2–31.7 | 6 (30.0) | 11.9–54.3 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 4 (20.0) | 5.7–43.7 | 3 (15.0) | 3.2–37.9 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Nausea | LAV | Any | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | 3 (15.0) | 3.2–37.9 | 1 (5.0) | .1–24.9 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | ||
| Vomiting | LAV | Any | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | ||
| Overall | LAV | Any | 5 (25.0) | 8.7–49.1 | 10 (50.0) | 27.2–72.8 | 8 (40.0) | 19.1–63.9 | 8 (40.0) | 19.1–63.9 |
| Grade 3 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | 4 (20.0) | 5.7–43.7 | ||
| PIV | Any | 2 (10.0) | 1.2–31.7 | 4 (20.0) | 5.7–43.7 | 5 (25.0) | 8.7–49.1 | 8 (40.0) | 19.1–63.9 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 |
Abbreviations: CI, confidence interval; LAV, live attenuated vaccine; PIV, purified inactivated vaccine.
Incidence of Solicited Systemic Adverse Events During the 21 Days Following Each Vaccination
| Symptom . | Vaccine . | Grade . | Group 1 (n = 20) . | . | Group 2 (n = 20) . | . | Group 3 (n = 20) . | . | Group 4 (n = 20) . | . |
|---|---|---|---|---|---|---|---|---|---|---|
| . | . | . | n (%) . | 95% CI . | n (%) . | 95% CI . | n (%) . | 95% CI . | n (%) . | 95% CI . |
| Abdominal Pain | LAV | Any | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 2 (10.0) | 1.2–31.7 | 0 (0.0) | .0–16.8 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Arthralgia | LAV | Any | 2 (10.0) | 1.2–31.7 | 5 (25.0) | 8.7–49.1 | 2 (10.0) | 1.2–31.7 | 4 (20.0) | 5.7–43.7 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 2 (10.0) | 1.2–31.7 | 0 (0.0) | .0–16.8 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Diarrhea | LAV | Any | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Fatigue | LAV | Any | 3 (15.0) | 3.2–37.9 | 8 (40.0) | 19.1–63.9 | 5 (25.0) | 8.7–49.1 | 5 (25.0) | 8.7–49.1 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 2 (10.0) | 1.2–31.7 | ||
| PIV | Any | 2 (10.0) | 1.2–31.7 | 2 (10.0) | 1.2–31.7 | 3 (15.0) | 3.2–37.9 | 4 (20.0) | 5.7–43.7 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Fever | LAV | Any | 0 (0.0) | .0–16.8 | 5 (25.0) | 8.7–49.1 | 0 (0.0) | .0–16.8 | 5 (25.0) | 8.7–49.1 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Headache | LAV | Any | 3 (15.0) | 3.2–37.9 | 8 (40.0) | 19.1–63.9 | 8 (40.0) | 19.1–63.9 | 6 (30.0) | 11.9–54.3 |
| Grade 3 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | 2 (10.0) | 1.2–31.7 | ||
| PIV | Any | 1 (5.0) | .1–24.9 | 3 (15.0) | 3.2–37.9 | 5 (25.0) | 8.7–49.1 | 3 (15.0) | 3.2–37.9 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Myalgia | LAV | Any | 1 (5.0) | .1–24.9 | 5 (25.0) | 8.7–49.1 | 2 (10.0) | 1.2–31.7 | 6 (30.0) | 11.9–54.3 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 4 (20.0) | 5.7–43.7 | 3 (15.0) | 3.2–37.9 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Nausea | LAV | Any | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | 3 (15.0) | 3.2–37.9 | 1 (5.0) | .1–24.9 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | ||
| Vomiting | LAV | Any | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | ||
| Overall | LAV | Any | 5 (25.0) | 8.7–49.1 | 10 (50.0) | 27.2–72.8 | 8 (40.0) | 19.1–63.9 | 8 (40.0) | 19.1–63.9 |
| Grade 3 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | 4 (20.0) | 5.7–43.7 | ||
| PIV | Any | 2 (10.0) | 1.2–31.7 | 4 (20.0) | 5.7–43.7 | 5 (25.0) | 8.7–49.1 | 8 (40.0) | 19.1–63.9 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 |
| Symptom . | Vaccine . | Grade . | Group 1 (n = 20) . | . | Group 2 (n = 20) . | . | Group 3 (n = 20) . | . | Group 4 (n = 20) . | . |
|---|---|---|---|---|---|---|---|---|---|---|
| . | . | . | n (%) . | 95% CI . | n (%) . | 95% CI . | n (%) . | 95% CI . | n (%) . | 95% CI . |
| Abdominal Pain | LAV | Any | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 2 (10.0) | 1.2–31.7 | 0 (0.0) | .0–16.8 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Arthralgia | LAV | Any | 2 (10.0) | 1.2–31.7 | 5 (25.0) | 8.7–49.1 | 2 (10.0) | 1.2–31.7 | 4 (20.0) | 5.7–43.7 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 2 (10.0) | 1.2–31.7 | 0 (0.0) | .0–16.8 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Diarrhea | LAV | Any | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Fatigue | LAV | Any | 3 (15.0) | 3.2–37.9 | 8 (40.0) | 19.1–63.9 | 5 (25.0) | 8.7–49.1 | 5 (25.0) | 8.7–49.1 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 2 (10.0) | 1.2–31.7 | ||
| PIV | Any | 2 (10.0) | 1.2–31.7 | 2 (10.0) | 1.2–31.7 | 3 (15.0) | 3.2–37.9 | 4 (20.0) | 5.7–43.7 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Fever | LAV | Any | 0 (0.0) | .0–16.8 | 5 (25.0) | 8.7–49.1 | 0 (0.0) | .0–16.8 | 5 (25.0) | 8.7–49.1 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Headache | LAV | Any | 3 (15.0) | 3.2–37.9 | 8 (40.0) | 19.1–63.9 | 8 (40.0) | 19.1–63.9 | 6 (30.0) | 11.9–54.3 |
| Grade 3 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | 2 (10.0) | 1.2–31.7 | ||
| PIV | Any | 1 (5.0) | .1–24.9 | 3 (15.0) | 3.2–37.9 | 5 (25.0) | 8.7–49.1 | 3 (15.0) | 3.2–37.9 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Myalgia | LAV | Any | 1 (5.0) | .1–24.9 | 5 (25.0) | 8.7–49.1 | 2 (10.0) | 1.2–31.7 | 6 (30.0) | 11.9–54.3 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 4 (20.0) | 5.7–43.7 | 3 (15.0) | 3.2–37.9 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | ||
| Nausea | LAV | Any | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | 3 (15.0) | 3.2–37.9 | 1 (5.0) | .1–24.9 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | ||
| Vomiting | LAV | Any | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | ||
| PIV | Any | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 | ||
| Overall | LAV | Any | 5 (25.0) | 8.7–49.1 | 10 (50.0) | 27.2–72.8 | 8 (40.0) | 19.1–63.9 | 8 (40.0) | 19.1–63.9 |
| Grade 3 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | 4 (20.0) | 5.7–43.7 | ||
| PIV | Any | 2 (10.0) | 1.2–31.7 | 4 (20.0) | 5.7–43.7 | 5 (25.0) | 8.7–49.1 | 8 (40.0) | 19.1–63.9 | |
| Grade 3 | 0 (0.0) | .0–16.8 | 1 (5.0) | .1–24.9 | 1 (5.0) | .1–24.9 | 0 (0.0) | .0–16.8 |
Abbreviations: CI, confidence interval; LAV, live attenuated vaccine; PIV, purified inactivated vaccine.
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