Table IV.
Identification of candidate genes based on their connection with known symbiosis genes in the 227 subnetwork
GeneGene DescriptionConnectivity Scorea
Medtr3g072710Nodulation-signaling pathway2 protein (NSP2)0.153
Medtr5g086110LysM domain-containing receptor-like kinase0.122
Medtr1g056530Nuclear transcription factor Y subunit A-10 (NF-YA1)0.083
Medtr5g086130LysM receptor kinase (LYK3)0.076
Medtr7g082260Zinc finger protein0.075
contig_119095_1SUPERMAN-like zinc finger protein0.072
Medtr3g031270Wound-induced protein0.071
Medtr5g099060Nodule inception protein (NIN)0.070
Medtr5g086120Receptor-like protein kinase (LYK4)0.069
Medtr7g085810ET-responsive TF (ERN1)0.069
contig_56789_1Calmodulin-binding protein0.067
Medtr4g079760TF basic helix-loop-helix300.064
Medtr3g015490Two-component response regulator ARR90.064
Medtr2g101830Rop guanine nucleotide-exchange factor (RopGEF12)0.064
contig_103831_1Myb-like transcription factor Myb0.062
contig_60935_1Protein phosphatase2C0.056
Medtr7g011900Isoliquiritigenin 2′-O-methyltransferase0.056
Medtr5g025840Kinase-like protein0.053
contig_8047_1LOB domain protein-like protein (LBD16)0.052
Medtr4g127140MADS box transcription factor0.050
Medtr5g025850Receptor-like protein kinase0.048
contig_49939_2Receptor-like kinase0.044
AC235664_104-Hydroxy-3-methyl-but-2-enyl diphosphate reductase (HDR)0.044
contig_167979_1Chaperone protein DnaJ-like protein0.044
contig_245351_1Receptor protein kinase0.044
contig_76132_1HDR0.044
Medtr4g104060Unknown protein0.044
Medtr5g0100102-C-Methyl-d-erythritol 2 4-cyclodiphosphate synthase (MCS)0.044
Medtr6g082180Unknown protein0.044
Medtr7g104250Unknown protein0.044
Medtr5g019070LRR receptor-like Ser/Thr-protein kinase FEI0.043
Medtr3g086320Pectate lyase0.043
Medtr2g068960ACC oxidase homologb0.040
Medtr2g069020ACC oxidase homologb0.040
Medtr8g097190Unknown protein0.040
contig_30837_1Receptor-like kinase0.040
Medtr2g068650Kinase-like protein0.039
Medtr4g051330Two-component response regulator ARR90.039
CX549419Weakly similar to UniRef100 A7P585 (Vitis vinifera)0.039
contig_60385_1Basic helix-loop-helix TF-like protein0.039
Medtr1g031540Receptor Ser/Thr kinase0.039
contig_68802_2Cytochrome P4500.038
Medtr4g107970WRKY transcription factor0.038
Medtr5g033030Multidrug resistance protein ATP-binding cassette transporter family0.038
Medtr2g069250Nodule-specific Gly-rich protein3C0.038
Medtr2g019750ET-responsive transcription factor3b0.038
Medtr8g026680Rac GTPase-activating protein0.038
contig_55524_1Zinc finger protein0.037
AC233082_23Receptor-like kinase0.037
Medtr5g026760Kinase-like protein0.036
Medtr8g074530Unknown protein0.033
Medtr7g020980ET-responsive TF (ERF115)0.033
contig_62786_1Inositol-tetrakisphosphate 1-kinase0.032
Medtr3g00876021-kD protein0.032
Medtr6g052300Metal transporter cyclin and CBS domain divalent metal cation transport mediator20.032
contig_94824_1LRR-RLK protein0.032
GeneGene DescriptionConnectivity Scorea
Medtr3g072710Nodulation-signaling pathway2 protein (NSP2)0.153
Medtr5g086110LysM domain-containing receptor-like kinase0.122
Medtr1g056530Nuclear transcription factor Y subunit A-10 (NF-YA1)0.083
Medtr5g086130LysM receptor kinase (LYK3)0.076
Medtr7g082260Zinc finger protein0.075
contig_119095_1SUPERMAN-like zinc finger protein0.072
Medtr3g031270Wound-induced protein0.071
Medtr5g099060Nodule inception protein (NIN)0.070
Medtr5g086120Receptor-like protein kinase (LYK4)0.069
Medtr7g085810ET-responsive TF (ERN1)0.069
contig_56789_1Calmodulin-binding protein0.067
Medtr4g079760TF basic helix-loop-helix300.064
Medtr3g015490Two-component response regulator ARR90.064
Medtr2g101830Rop guanine nucleotide-exchange factor (RopGEF12)0.064
contig_103831_1Myb-like transcription factor Myb0.062
contig_60935_1Protein phosphatase2C0.056
Medtr7g011900Isoliquiritigenin 2′-O-methyltransferase0.056
Medtr5g025840Kinase-like protein0.053
contig_8047_1LOB domain protein-like protein (LBD16)0.052
Medtr4g127140MADS box transcription factor0.050
Medtr5g025850Receptor-like protein kinase0.048
contig_49939_2Receptor-like kinase0.044
AC235664_104-Hydroxy-3-methyl-but-2-enyl diphosphate reductase (HDR)0.044
contig_167979_1Chaperone protein DnaJ-like protein0.044
contig_245351_1Receptor protein kinase0.044
contig_76132_1HDR0.044
Medtr4g104060Unknown protein0.044
Medtr5g0100102-C-Methyl-d-erythritol 2 4-cyclodiphosphate synthase (MCS)0.044
Medtr6g082180Unknown protein0.044
Medtr7g104250Unknown protein0.044
Medtr5g019070LRR receptor-like Ser/Thr-protein kinase FEI0.043
Medtr3g086320Pectate lyase0.043
Medtr2g068960ACC oxidase homologb0.040
Medtr2g069020ACC oxidase homologb0.040
Medtr8g097190Unknown protein0.040
contig_30837_1Receptor-like kinase0.040
Medtr2g068650Kinase-like protein0.039
Medtr4g051330Two-component response regulator ARR90.039
CX549419Weakly similar to UniRef100 A7P585 (Vitis vinifera)0.039
contig_60385_1Basic helix-loop-helix TF-like protein0.039
Medtr1g031540Receptor Ser/Thr kinase0.039
contig_68802_2Cytochrome P4500.038
Medtr4g107970WRKY transcription factor0.038
Medtr5g033030Multidrug resistance protein ATP-binding cassette transporter family0.038
Medtr2g069250Nodule-specific Gly-rich protein3C0.038
Medtr2g019750ET-responsive transcription factor3b0.038
Medtr8g026680Rac GTPase-activating protein0.038
contig_55524_1Zinc finger protein0.037
AC233082_23Receptor-like kinase0.037
Medtr5g026760Kinase-like protein0.036
Medtr8g074530Unknown protein0.033
Medtr7g020980ET-responsive TF (ERF115)0.033
contig_62786_1Inositol-tetrakisphosphate 1-kinase0.032
Medtr3g00876021-kD protein0.032
Medtr6g052300Metal transporter cyclin and CBS domain divalent metal cation transport mediator20.032
contig_94824_1LRR-RLK protein0.032
a

The connectivity score, obtained by applying a regularized Laplacian kernel method to the inferred regulatory network, measures connectivity to the known symbiosis genes. The top 56 genes shown were selected such that their score was 2 sd above the mean. Input symbiosis genes are shown in boldface.

b

Annotated as 2-oxoglutarate-Fe(II) oxygenase family oxidoreductase in IMGA 4.0 version 1.

Table IV.
Identification of candidate genes based on their connection with known symbiosis genes in the 227 subnetwork
GeneGene DescriptionConnectivity Scorea
Medtr3g072710Nodulation-signaling pathway2 protein (NSP2)0.153
Medtr5g086110LysM domain-containing receptor-like kinase0.122
Medtr1g056530Nuclear transcription factor Y subunit A-10 (NF-YA1)0.083
Medtr5g086130LysM receptor kinase (LYK3)0.076
Medtr7g082260Zinc finger protein0.075
contig_119095_1SUPERMAN-like zinc finger protein0.072
Medtr3g031270Wound-induced protein0.071
Medtr5g099060Nodule inception protein (NIN)0.070
Medtr5g086120Receptor-like protein kinase (LYK4)0.069
Medtr7g085810ET-responsive TF (ERN1)0.069
contig_56789_1Calmodulin-binding protein0.067
Medtr4g079760TF basic helix-loop-helix300.064
Medtr3g015490Two-component response regulator ARR90.064
Medtr2g101830Rop guanine nucleotide-exchange factor (RopGEF12)0.064
contig_103831_1Myb-like transcription factor Myb0.062
contig_60935_1Protein phosphatase2C0.056
Medtr7g011900Isoliquiritigenin 2′-O-methyltransferase0.056
Medtr5g025840Kinase-like protein0.053
contig_8047_1LOB domain protein-like protein (LBD16)0.052
Medtr4g127140MADS box transcription factor0.050
Medtr5g025850Receptor-like protein kinase0.048
contig_49939_2Receptor-like kinase0.044
AC235664_104-Hydroxy-3-methyl-but-2-enyl diphosphate reductase (HDR)0.044
contig_167979_1Chaperone protein DnaJ-like protein0.044
contig_245351_1Receptor protein kinase0.044
contig_76132_1HDR0.044
Medtr4g104060Unknown protein0.044
Medtr5g0100102-C-Methyl-d-erythritol 2 4-cyclodiphosphate synthase (MCS)0.044
Medtr6g082180Unknown protein0.044
Medtr7g104250Unknown protein0.044
Medtr5g019070LRR receptor-like Ser/Thr-protein kinase FEI0.043
Medtr3g086320Pectate lyase0.043
Medtr2g068960ACC oxidase homologb0.040
Medtr2g069020ACC oxidase homologb0.040
Medtr8g097190Unknown protein0.040
contig_30837_1Receptor-like kinase0.040
Medtr2g068650Kinase-like protein0.039
Medtr4g051330Two-component response regulator ARR90.039
CX549419Weakly similar to UniRef100 A7P585 (Vitis vinifera)0.039
contig_60385_1Basic helix-loop-helix TF-like protein0.039
Medtr1g031540Receptor Ser/Thr kinase0.039
contig_68802_2Cytochrome P4500.038
Medtr4g107970WRKY transcription factor0.038
Medtr5g033030Multidrug resistance protein ATP-binding cassette transporter family0.038
Medtr2g069250Nodule-specific Gly-rich protein3C0.038
Medtr2g019750ET-responsive transcription factor3b0.038
Medtr8g026680Rac GTPase-activating protein0.038
contig_55524_1Zinc finger protein0.037
AC233082_23Receptor-like kinase0.037
Medtr5g026760Kinase-like protein0.036
Medtr8g074530Unknown protein0.033
Medtr7g020980ET-responsive TF (ERF115)0.033
contig_62786_1Inositol-tetrakisphosphate 1-kinase0.032
Medtr3g00876021-kD protein0.032
Medtr6g052300Metal transporter cyclin and CBS domain divalent metal cation transport mediator20.032
contig_94824_1LRR-RLK protein0.032
GeneGene DescriptionConnectivity Scorea
Medtr3g072710Nodulation-signaling pathway2 protein (NSP2)0.153
Medtr5g086110LysM domain-containing receptor-like kinase0.122
Medtr1g056530Nuclear transcription factor Y subunit A-10 (NF-YA1)0.083
Medtr5g086130LysM receptor kinase (LYK3)0.076
Medtr7g082260Zinc finger protein0.075
contig_119095_1SUPERMAN-like zinc finger protein0.072
Medtr3g031270Wound-induced protein0.071
Medtr5g099060Nodule inception protein (NIN)0.070
Medtr5g086120Receptor-like protein kinase (LYK4)0.069
Medtr7g085810ET-responsive TF (ERN1)0.069
contig_56789_1Calmodulin-binding protein0.067
Medtr4g079760TF basic helix-loop-helix300.064
Medtr3g015490Two-component response regulator ARR90.064
Medtr2g101830Rop guanine nucleotide-exchange factor (RopGEF12)0.064
contig_103831_1Myb-like transcription factor Myb0.062
contig_60935_1Protein phosphatase2C0.056
Medtr7g011900Isoliquiritigenin 2′-O-methyltransferase0.056
Medtr5g025840Kinase-like protein0.053
contig_8047_1LOB domain protein-like protein (LBD16)0.052
Medtr4g127140MADS box transcription factor0.050
Medtr5g025850Receptor-like protein kinase0.048
contig_49939_2Receptor-like kinase0.044
AC235664_104-Hydroxy-3-methyl-but-2-enyl diphosphate reductase (HDR)0.044
contig_167979_1Chaperone protein DnaJ-like protein0.044
contig_245351_1Receptor protein kinase0.044
contig_76132_1HDR0.044
Medtr4g104060Unknown protein0.044
Medtr5g0100102-C-Methyl-d-erythritol 2 4-cyclodiphosphate synthase (MCS)0.044
Medtr6g082180Unknown protein0.044
Medtr7g104250Unknown protein0.044
Medtr5g019070LRR receptor-like Ser/Thr-protein kinase FEI0.043
Medtr3g086320Pectate lyase0.043
Medtr2g068960ACC oxidase homologb0.040
Medtr2g069020ACC oxidase homologb0.040
Medtr8g097190Unknown protein0.040
contig_30837_1Receptor-like kinase0.040
Medtr2g068650Kinase-like protein0.039
Medtr4g051330Two-component response regulator ARR90.039
CX549419Weakly similar to UniRef100 A7P585 (Vitis vinifera)0.039
contig_60385_1Basic helix-loop-helix TF-like protein0.039
Medtr1g031540Receptor Ser/Thr kinase0.039
contig_68802_2Cytochrome P4500.038
Medtr4g107970WRKY transcription factor0.038
Medtr5g033030Multidrug resistance protein ATP-binding cassette transporter family0.038
Medtr2g069250Nodule-specific Gly-rich protein3C0.038
Medtr2g019750ET-responsive transcription factor3b0.038
Medtr8g026680Rac GTPase-activating protein0.038
contig_55524_1Zinc finger protein0.037
AC233082_23Receptor-like kinase0.037
Medtr5g026760Kinase-like protein0.036
Medtr8g074530Unknown protein0.033
Medtr7g020980ET-responsive TF (ERF115)0.033
contig_62786_1Inositol-tetrakisphosphate 1-kinase0.032
Medtr3g00876021-kD protein0.032
Medtr6g052300Metal transporter cyclin and CBS domain divalent metal cation transport mediator20.032
contig_94824_1LRR-RLK protein0.032
a

The connectivity score, obtained by applying a regularized Laplacian kernel method to the inferred regulatory network, measures connectivity to the known symbiosis genes. The top 56 genes shown were selected such that their score was 2 sd above the mean. Input symbiosis genes are shown in boldface.

b

Annotated as 2-oxoglutarate-Fe(II) oxygenase family oxidoreductase in IMGA 4.0 version 1.

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