Table 1
Open in new tab

Summary of computational approaches for identifying miRNA-mediated RNA–RNA interaction

MethodsInput dataAdvantagesDisadvantagesPMID
RatiomiRNA–target regulation• Simple and fast• The number of ceRNA is greatly overestimated27365046
• Ignore expression data
HyperTmiRNA–target regulation• Simple and statistically significant• The number of ceRNA is greatly overestimated24297251
HyperCmiRNA–target regulation; RNA expression• Simple and statistically significant• Ignore non-linear interactions26304537
• Ignore miRNA expression data
SCmiRNA–target regulation; miRNA and RNA expression• Evaluate the influence of miRNAs using SC• Ignore MREs information25033876
CMImiRNA–target regulation; miRNA and RNA expression• Consider non-linear interactions• Ignore MREs information22,000,015
• Time consuming
CerniamiRNA–target regulation; miRNA and RNA expression; MREs• Contain MREs information• Ignore non-linear interactions31077152
MethodsInput dataAdvantagesDisadvantagesPMID
RatiomiRNA–target regulation• Simple and fast• The number of ceRNA is greatly overestimated27365046
• Ignore expression data
HyperTmiRNA–target regulation• Simple and statistically significant• The number of ceRNA is greatly overestimated24297251
HyperCmiRNA–target regulation; RNA expression• Simple and statistically significant• Ignore non-linear interactions26304537
• Ignore miRNA expression data
SCmiRNA–target regulation; miRNA and RNA expression• Evaluate the influence of miRNAs using SC• Ignore MREs information25033876
CMImiRNA–target regulation; miRNA and RNA expression• Consider non-linear interactions• Ignore MREs information22,000,015
• Time consuming
CerniamiRNA–target regulation; miRNA and RNA expression; MREs• Contain MREs information• Ignore non-linear interactions31077152
Table 1
Open in new tab

Summary of computational approaches for identifying miRNA-mediated RNA–RNA interaction

MethodsInput dataAdvantagesDisadvantagesPMID
RatiomiRNA–target regulation• Simple and fast• The number of ceRNA is greatly overestimated27365046
• Ignore expression data
HyperTmiRNA–target regulation• Simple and statistically significant• The number of ceRNA is greatly overestimated24297251
HyperCmiRNA–target regulation; RNA expression• Simple and statistically significant• Ignore non-linear interactions26304537
• Ignore miRNA expression data
SCmiRNA–target regulation; miRNA and RNA expression• Evaluate the influence of miRNAs using SC• Ignore MREs information25033876
CMImiRNA–target regulation; miRNA and RNA expression• Consider non-linear interactions• Ignore MREs information22,000,015
• Time consuming
CerniamiRNA–target regulation; miRNA and RNA expression; MREs• Contain MREs information• Ignore non-linear interactions31077152
MethodsInput dataAdvantagesDisadvantagesPMID
RatiomiRNA–target regulation• Simple and fast• The number of ceRNA is greatly overestimated27365046
• Ignore expression data
HyperTmiRNA–target regulation• Simple and statistically significant• The number of ceRNA is greatly overestimated24297251
HyperCmiRNA–target regulation; RNA expression• Simple and statistically significant• Ignore non-linear interactions26304537
• Ignore miRNA expression data
SCmiRNA–target regulation; miRNA and RNA expression• Evaluate the influence of miRNAs using SC• Ignore MREs information25033876
CMImiRNA–target regulation; miRNA and RNA expression• Consider non-linear interactions• Ignore MREs information22,000,015
• Time consuming
CerniamiRNA–target regulation; miRNA and RNA expression; MREs• Contain MREs information• Ignore non-linear interactions31077152
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