| Characteristic . | . | |||
|---|---|---|---|---|
| . | Total (n = 53) . | APOE genotype . | ||
| . | . | ε3ε4 carriers (n = 15) . | ε3ε3 carriers (n = 38) . | P value . |
| Age (years) | 64.2 (7.2) | 65.0 (7.9) | 64.0 (6.9) | 0.65 |
| Sex (male/female) | 21/33 | 7/9 | 15/22 | |
| Education (years) | 14.2 (2.9) | 14.5 (2.8) | 14.1 (3.0) | 0.63 |
| Serum free DHA (µg/ml) | 1.23 (0.63) | 1.22 (0.59) | 1.23 (0.66) | 0.96 |
| Serum LPC DHA (µg/ml) | 2.15 (1.36) | 2.23 (1.49) | 2.10 (1.26) | 0.43 |
| Blood pressure | ||||
| Systolic (mm Hg) | 133 (17) | 121 (23) | 126 (14) | 0.61 |
| Diastolic (mm Hg) | 74 (7.6) | 72 (7.3) | 75 (7.8) | 0.10 |
| BMI (kg/m2) | 26.9 (4.0) | 27.1 (4.9) | 26.9 (3.8) | 0.87 |
| Serum glucose (mmol/l) | 5.19 (0.57) | 5.26 (0.38) | 5.17 (0.63) | 0.63 |
| Serum cholesterol (mmol/l) | ||||
| Total | 5.08 (0.9) | 5.04 (1.2) | 5.12 (0.8) | 0.82 |
| HDL | 1.42 (4.5) | 1.39 (5.2) | 1.44 (3.9) | 0.81 |
| Serum TG (mmol/l) | 1.52 (0.5) | 1.59 (0.6) | 1.47 (0.4) | 0.48 |
| Serum BDNF (pg/ml) | 18958 (4676) | 19359 (4702) | 18144 (4589) | 0.13 |
| Brain volume | ||||
| Hippocampal volume (ratio of total intracranial volume) | 0.0045 (0.00038) | 0.0044 (0.00046) | 0.0045 (0.00035) | 0.36 |
| Entorhinal volume (ratio of total intracranial volume) | 0.0024 (0.00031) | 0.0023 (0.00025) | 0.0024 (0.00033) | 0.29 |
| Cognition | ||||
| CVLT (delayed free recall) | 10.99 (2.3) | 10.43 (2.7) | 11.16 (2.3) | 0.28 |
| MOCA (delayed recall) | 3.11 (1.3) | 3.07 (1.2) | 3.24 (1.4) | 0.68 |
| MOCA (total) | 27.87 (1.7) | 27.73 (1.7) | 27.93 (1.8) | 0.72 |
| Digital span (total score) | 19.01 (3.4) | 18.80 (3.2) | 19.79 (3.6) | 0.37 |
| Characteristic . | . | |||
|---|---|---|---|---|
| . | Total (n = 53) . | APOE genotype . | ||
| . | . | ε3ε4 carriers (n = 15) . | ε3ε3 carriers (n = 38) . | P value . |
| Age (years) | 64.2 (7.2) | 65.0 (7.9) | 64.0 (6.9) | 0.65 |
| Sex (male/female) | 21/33 | 7/9 | 15/22 | |
| Education (years) | 14.2 (2.9) | 14.5 (2.8) | 14.1 (3.0) | 0.63 |
| Serum free DHA (µg/ml) | 1.23 (0.63) | 1.22 (0.59) | 1.23 (0.66) | 0.96 |
| Serum LPC DHA (µg/ml) | 2.15 (1.36) | 2.23 (1.49) | 2.10 (1.26) | 0.43 |
| Blood pressure | ||||
| Systolic (mm Hg) | 133 (17) | 121 (23) | 126 (14) | 0.61 |
| Diastolic (mm Hg) | 74 (7.6) | 72 (7.3) | 75 (7.8) | 0.10 |
| BMI (kg/m2) | 26.9 (4.0) | 27.1 (4.9) | 26.9 (3.8) | 0.87 |
| Serum glucose (mmol/l) | 5.19 (0.57) | 5.26 (0.38) | 5.17 (0.63) | 0.63 |
| Serum cholesterol (mmol/l) | ||||
| Total | 5.08 (0.9) | 5.04 (1.2) | 5.12 (0.8) | 0.82 |
| HDL | 1.42 (4.5) | 1.39 (5.2) | 1.44 (3.9) | 0.81 |
| Serum TG (mmol/l) | 1.52 (0.5) | 1.59 (0.6) | 1.47 (0.4) | 0.48 |
| Serum BDNF (pg/ml) | 18958 (4676) | 19359 (4702) | 18144 (4589) | 0.13 |
| Brain volume | ||||
| Hippocampal volume (ratio of total intracranial volume) | 0.0045 (0.00038) | 0.0044 (0.00046) | 0.0045 (0.00035) | 0.36 |
| Entorhinal volume (ratio of total intracranial volume) | 0.0024 (0.00031) | 0.0023 (0.00025) | 0.0024 (0.00033) | 0.29 |
| Cognition | ||||
| CVLT (delayed free recall) | 10.99 (2.3) | 10.43 (2.7) | 11.16 (2.3) | 0.28 |
| MOCA (delayed recall) | 3.11 (1.3) | 3.07 (1.2) | 3.24 (1.4) | 0.68 |
| MOCA (total) | 27.87 (1.7) | 27.73 (1.7) | 27.93 (1.8) | 0.72 |
| Digital span (total score) | 19.01 (3.4) | 18.80 (3.2) | 19.79 (3.6) | 0.37 |
Data are presented as mean (SD) for normally distributed data or median for non-normal distributions. The two groups were compared by an independent sample t-test. Serum free DHA is measured as total DHA in serum, in the free/non-esterified fatty acid form. BDNF, brain derived neurotrophic factor; CVLT, California Verbal Learning Test, DHA, docosahexaenoic acid; HDL, high density lipoprotein, LPC; Lysophosphatidylcholine; MOCA, Montreal Cognitive Assessment; TG, triglycerides
| Characteristic . | . | |||
|---|---|---|---|---|
| . | Total (n = 53) . | APOE genotype . | ||
| . | . | ε3ε4 carriers (n = 15) . | ε3ε3 carriers (n = 38) . | P value . |
| Age (years) | 64.2 (7.2) | 65.0 (7.9) | 64.0 (6.9) | 0.65 |
| Sex (male/female) | 21/33 | 7/9 | 15/22 | |
| Education (years) | 14.2 (2.9) | 14.5 (2.8) | 14.1 (3.0) | 0.63 |
| Serum free DHA (µg/ml) | 1.23 (0.63) | 1.22 (0.59) | 1.23 (0.66) | 0.96 |
| Serum LPC DHA (µg/ml) | 2.15 (1.36) | 2.23 (1.49) | 2.10 (1.26) | 0.43 |
| Blood pressure | ||||
| Systolic (mm Hg) | 133 (17) | 121 (23) | 126 (14) | 0.61 |
| Diastolic (mm Hg) | 74 (7.6) | 72 (7.3) | 75 (7.8) | 0.10 |
| BMI (kg/m2) | 26.9 (4.0) | 27.1 (4.9) | 26.9 (3.8) | 0.87 |
| Serum glucose (mmol/l) | 5.19 (0.57) | 5.26 (0.38) | 5.17 (0.63) | 0.63 |
| Serum cholesterol (mmol/l) | ||||
| Total | 5.08 (0.9) | 5.04 (1.2) | 5.12 (0.8) | 0.82 |
| HDL | 1.42 (4.5) | 1.39 (5.2) | 1.44 (3.9) | 0.81 |
| Serum TG (mmol/l) | 1.52 (0.5) | 1.59 (0.6) | 1.47 (0.4) | 0.48 |
| Serum BDNF (pg/ml) | 18958 (4676) | 19359 (4702) | 18144 (4589) | 0.13 |
| Brain volume | ||||
| Hippocampal volume (ratio of total intracranial volume) | 0.0045 (0.00038) | 0.0044 (0.00046) | 0.0045 (0.00035) | 0.36 |
| Entorhinal volume (ratio of total intracranial volume) | 0.0024 (0.00031) | 0.0023 (0.00025) | 0.0024 (0.00033) | 0.29 |
| Cognition | ||||
| CVLT (delayed free recall) | 10.99 (2.3) | 10.43 (2.7) | 11.16 (2.3) | 0.28 |
| MOCA (delayed recall) | 3.11 (1.3) | 3.07 (1.2) | 3.24 (1.4) | 0.68 |
| MOCA (total) | 27.87 (1.7) | 27.73 (1.7) | 27.93 (1.8) | 0.72 |
| Digital span (total score) | 19.01 (3.4) | 18.80 (3.2) | 19.79 (3.6) | 0.37 |
| Characteristic . | . | |||
|---|---|---|---|---|
| . | Total (n = 53) . | APOE genotype . | ||
| . | . | ε3ε4 carriers (n = 15) . | ε3ε3 carriers (n = 38) . | P value . |
| Age (years) | 64.2 (7.2) | 65.0 (7.9) | 64.0 (6.9) | 0.65 |
| Sex (male/female) | 21/33 | 7/9 | 15/22 | |
| Education (years) | 14.2 (2.9) | 14.5 (2.8) | 14.1 (3.0) | 0.63 |
| Serum free DHA (µg/ml) | 1.23 (0.63) | 1.22 (0.59) | 1.23 (0.66) | 0.96 |
| Serum LPC DHA (µg/ml) | 2.15 (1.36) | 2.23 (1.49) | 2.10 (1.26) | 0.43 |
| Blood pressure | ||||
| Systolic (mm Hg) | 133 (17) | 121 (23) | 126 (14) | 0.61 |
| Diastolic (mm Hg) | 74 (7.6) | 72 (7.3) | 75 (7.8) | 0.10 |
| BMI (kg/m2) | 26.9 (4.0) | 27.1 (4.9) | 26.9 (3.8) | 0.87 |
| Serum glucose (mmol/l) | 5.19 (0.57) | 5.26 (0.38) | 5.17 (0.63) | 0.63 |
| Serum cholesterol (mmol/l) | ||||
| Total | 5.08 (0.9) | 5.04 (1.2) | 5.12 (0.8) | 0.82 |
| HDL | 1.42 (4.5) | 1.39 (5.2) | 1.44 (3.9) | 0.81 |
| Serum TG (mmol/l) | 1.52 (0.5) | 1.59 (0.6) | 1.47 (0.4) | 0.48 |
| Serum BDNF (pg/ml) | 18958 (4676) | 19359 (4702) | 18144 (4589) | 0.13 |
| Brain volume | ||||
| Hippocampal volume (ratio of total intracranial volume) | 0.0045 (0.00038) | 0.0044 (0.00046) | 0.0045 (0.00035) | 0.36 |
| Entorhinal volume (ratio of total intracranial volume) | 0.0024 (0.00031) | 0.0023 (0.00025) | 0.0024 (0.00033) | 0.29 |
| Cognition | ||||
| CVLT (delayed free recall) | 10.99 (2.3) | 10.43 (2.7) | 11.16 (2.3) | 0.28 |
| MOCA (delayed recall) | 3.11 (1.3) | 3.07 (1.2) | 3.24 (1.4) | 0.68 |
| MOCA (total) | 27.87 (1.7) | 27.73 (1.7) | 27.93 (1.8) | 0.72 |
| Digital span (total score) | 19.01 (3.4) | 18.80 (3.2) | 19.79 (3.6) | 0.37 |
Data are presented as mean (SD) for normally distributed data or median for non-normal distributions. The two groups were compared by an independent sample t-test. Serum free DHA is measured as total DHA in serum, in the free/non-esterified fatty acid form. BDNF, brain derived neurotrophic factor; CVLT, California Verbal Learning Test, DHA, docosahexaenoic acid; HDL, high density lipoprotein, LPC; Lysophosphatidylcholine; MOCA, Montreal Cognitive Assessment; TG, triglycerides
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