Table 1 Open in new tab Fetal pH, blood...

Group

Baseline

UCO
(5 min)

UCO
(17 min)

+2 h

+4 h

+6 h

+1 day

+3 days

+7 days

+14 days

+21 days

Sham

7.36 ± 0.01

7.35 ± 0.01

7.34 ± 0.01

7.35 ± 0.01

7.34 ± 0.01

7.33 ± 0.01

UCO

7.35 ± 0.01

7.03 ± 0.01^*

6.84 ± 0.01^*

7.29 ± 0.02^*

7.38 ± 0.01

7.40 ± 0.01^*

7.36 ± 0.01

7.35 ± 0.01

7.36 ± 0.01^*

p_aCO₂ (mmHg)

Sham

48.5 ± 0.7

47.1 ± 0.8

46.6 ± 0.8

47.3 ± 0.9

46.1 ± 1.1

46.7 ± 0.9

48.4 ± 0.7

48.4 ± 0.8

49.1 ± 0.8

48.6 ± 1.0

49.4 ± 1.2

UCO

50.7 ± 1.4

99.7 ± 2.6^*

136.4 ± 6.0^*

47.8 ± 0.8

47.7 ± 1.1

48.5 ± 0.7

46.3 ± 1.4

46.8 ± 1.5

49.2 ± 1.8

50.6 ± 1.4

48.6 ± 1.1

p_aO₂ (mmHg)

Sham

25.6 ± 0.6

24.6 ± 0.7

24.3 ± 0.6

25.5 ± 0.7

24.9 ± 0.5

25.7 ± 0.7

26.2 ± 0.8

27.0 ± 0.7

25.3 ± 1.1

26.0 ± 1.4

22.6 ± 1.3

UCO

24.7 ± 0.8

6.6 ± 0.4^*

9.5 ± 1.2^*

27.2 ± 1.2

23.5 ± 1.0

25.4 ± 1.0

29.1 ± 1.0^*

31.1 ± 1.2^*

29.4 ± 1.5^*

28.4 ± 1.2

26.5 ± 1.8

Hct (%)

Sham

27.2 ± 0.7

26.2 ± 0.8

26.1 ± 0.9

26.7 ± 0.7

25.4 ± 0.7

25.9 ± 0.9

26.9 ± 0.8

29.4 ± 1.4

31.6 ± 1.8

31.3 ± 1.3

31.4 ± 0.8

UCO

26.2 ± 0.7

27.8 ± 1.1

28.2 ± 0.8

28.1 ± 0.7

27.4 ± 0.5^*

27.7 ± 0.8

29.0 ± 0.5^*

30.2 ± 2.2

33.6 ± 3.7

35.2 ± 4.4

30.5 ± 1.2

O₂ct (mmol/l)

Sham

3.6 ± 0.1

3.4 ± 0.1

3.3 ± 0.2

3.6 ± 0.1

3.2 ± 0.1

3.4 ± 0.2

3.7 ± 0.2

3.9 ± 0.1

3.9 ± 0.2

6.6 ± 2.7

3.3 ± 0.3

UCO

3.6 ± 0.1

0.4 ± 0.1^*

0.5 ± 0.1^*

4.3 ± 0.3^*

3.6 ± 0.2

4.1 ± 0.2^*

4.5 ± 0.1^*

4.6 ± 0.2^*

4.5 ± 0.2

4.2 ± 0.2^*

Lactate (mmol/l)

Sham

0.9 ± 0.1

0.9 ± 0.03

0.9 ± 0.1

0.9 ± 0.0

1.0 ± 0.0

0.9 ± 0.1

0.8 ± 0.04

0.9 ± 0.0

0.8 ± 0.0

1.1 ± 0.1

UCO

0.8 ± 0.1

3.9 ± 0.2^*

6.2 ± 0.3^*

4.8 ± 0.7^*

3.0 ± 0.5^*

2.1 ± 0.2^*

1.5 ± 0.2^*

0.9 ± 0.1

0.7 ± 0.0^*

0.8 ± 0.0

Glucose (mmol/l)

Sham

1.1 ± 0.1

1.0 ± 0.04

1.0 ± 0.1

1.2 ± 0.1

1.1 ± 0.1

1.2 ± 0.1

1.1 ± 0.1

1.0 ± 0.1

0.8 ± 0.1

UCO

1.0 ± 0.1

0.4 ± 0.1^*

0.6 ± 0.1^*

1.3 ± 0.1

1.4 ± 0.1^*

1.1 ± 0.1

0.9 ± 0.1

0.9 ± 0.0

Group

Baseline

UCO
(5 min)

UCO
(17 min)

+2 h

+4 h

+6 h

+1 day

+3 days

+7 days

+14 days

+21 days

Sham

7.36 ± 0.01

7.35 ± 0.01

7.34 ± 0.01

7.35 ± 0.01

7.34 ± 0.01

7.33 ± 0.01

UCO

7.35 ± 0.01

7.03 ± 0.01^*

6.84 ± 0.01^*

7.29 ± 0.02^*

7.38 ± 0.01

7.40 ± 0.01^*

7.36 ± 0.01

7.35 ± 0.01

7.36 ± 0.01^*

p_aCO₂ (mmHg)

Sham

48.5 ± 0.7

47.1 ± 0.8

46.6 ± 0.8

47.3 ± 0.9

46.1 ± 1.1

46.7 ± 0.9

48.4 ± 0.7

48.4 ± 0.8

49.1 ± 0.8

48.6 ± 1.0

49.4 ± 1.2

UCO

50.7 ± 1.4

99.7 ± 2.6^*

136.4 ± 6.0^*

47.8 ± 0.8

47.7 ± 1.1

48.5 ± 0.7

46.3 ± 1.4

46.8 ± 1.5

49.2 ± 1.8

50.6 ± 1.4

48.6 ± 1.1

p_aO₂ (mmHg)

Sham

25.6 ± 0.6

24.6 ± 0.7

24.3 ± 0.6

25.5 ± 0.7

24.9 ± 0.5

25.7 ± 0.7

26.2 ± 0.8

27.0 ± 0.7

25.3 ± 1.1

26.0 ± 1.4

22.6 ± 1.3

UCO

24.7 ± 0.8

6.6 ± 0.4^*

9.5 ± 1.2^*

27.2 ± 1.2

23.5 ± 1.0

25.4 ± 1.0

29.1 ± 1.0^*

31.1 ± 1.2^*

29.4 ± 1.5^*

28.4 ± 1.2

26.5 ± 1.8

Hct (%)

Sham

27.2 ± 0.7

26.2 ± 0.8

26.1 ± 0.9

26.7 ± 0.7

25.4 ± 0.7

25.9 ± 0.9

26.9 ± 0.8

29.4 ± 1.4

31.6 ± 1.8

31.3 ± 1.3

31.4 ± 0.8

UCO

26.2 ± 0.7

27.8 ± 1.1

28.2 ± 0.8

28.1 ± 0.7

27.4 ± 0.5^*

27.7 ± 0.8

29.0 ± 0.5^*

30.2 ± 2.2

33.6 ± 3.7

35.2 ± 4.4

30.5 ± 1.2

O₂ct (mmol/l)

Sham

3.6 ± 0.1

3.4 ± 0.1

3.3 ± 0.2

3.6 ± 0.1

3.2 ± 0.1

3.4 ± 0.2

3.7 ± 0.2

3.9 ± 0.1

3.9 ± 0.2

6.6 ± 2.7

3.3 ± 0.3

UCO

3.6 ± 0.1

0.4 ± 0.1^*

0.5 ± 0.1^*

4.3 ± 0.3^*

3.6 ± 0.2

4.1 ± 0.2^*

4.5 ± 0.1^*

4.6 ± 0.2^*

4.5 ± 0.2

4.2 ± 0.2^*

Lactate (mmol/l)

Sham

0.9 ± 0.1

0.9 ± 0.03

0.9 ± 0.1

0.9 ± 0.0

1.0 ± 0.0

0.9 ± 0.1

0.8 ± 0.04

0.9 ± 0.0

0.8 ± 0.0

1.1 ± 0.1

UCO

0.8 ± 0.1

3.9 ± 0.2^*

6.2 ± 0.3^*

4.8 ± 0.7^*

3.0 ± 0.5^*

2.1 ± 0.2^*

1.5 ± 0.2^*

0.9 ± 0.1

0.7 ± 0.0^*

0.8 ± 0.0

Glucose (mmol/l)

Sham

1.1 ± 0.1

1.0 ± 0.04

1.0 ± 0.1

1.2 ± 0.1

1.1 ± 0.1

1.2 ± 0.1

1.1 ± 0.1

1.0 ± 0.1

0.8 ± 0.1

UCO

1.0 ± 0.1

0.4 ± 0.1^*

0.6 ± 0.1^*

1.3 ± 0.1

1.4 ± 0.1^*

1.1 ± 0.1

0.9 ± 0.1

0.9 ± 0.0

Table 1

Open in new tab

Fetal pH, blood gases and metabolites from the 21-day recovery groups

	Group	Baseline	UCO (5 min)	UCO (17 min)	+2 h	+4 h	+6 h	+1 day	+3 days	+7 days	+14 days	+21 days
pH	Sham	7.36 ± 0.01	7.36 ± 0.01	7.36 ± 0.01	7.36 ± 0.01	7.35 ± 0.01	7.35 ± 0.01	7.35 ± 0.01	7.34 ± 0.01	7.35 ± 0.01	7.34 ± 0.01	7.33 ± 0.01
pH	UCO	7.35 ± 0.01	7.03 ± 0.01^*	6.84 ± 0.01^*	7.29 ± 0.02^*	7.38 ± 0.01	7.40 ± 0.01^*	7.36 ± 0.01	7.36 ± 0.01	7.36 ± 0.01	7.35 ± 0.01	7.36 ± 0.01^*
p_aCO₂ (mmHg)	Sham	48.5 ± 0.7	47.1 ± 0.8	46.6 ± 0.8	47.3 ± 0.9	46.1 ± 1.1	46.7 ± 0.9	48.4 ± 0.7	48.4 ± 0.8	49.1 ± 0.8	48.6 ± 1.0	49.4 ± 1.2
p_aCO₂ (mmHg)	UCO	50.7 ± 1.4	99.7 ± 2.6^*	136.4 ± 6.0^*	47.8 ± 0.8	47.7 ± 1.1	48.5 ± 0.7	46.3 ± 1.4	46.8 ± 1.5	49.2 ± 1.8	50.6 ± 1.4	48.6 ± 1.1
p_aO₂ (mmHg)	Sham	25.6 ± 0.6	24.6 ± 0.7	24.3 ± 0.6	25.5 ± 0.7	24.9 ± 0.5	25.7 ± 0.7	26.2 ± 0.8	27.0 ± 0.7	25.3 ± 1.1	26.0 ± 1.4	22.6 ± 1.3
p_aO₂ (mmHg)	UCO	24.7 ± 0.8	6.6 ± 0.4^*	9.5 ± 1.2^*	27.2 ± 1.2	23.5 ± 1.0	25.4 ± 1.0	29.1 ± 1.0^*	31.1 ± 1.2^*	29.4 ± 1.5^*	28.4 ± 1.2	26.5 ± 1.8
Hct (%)	Sham	27.2 ± 0.7	26.2 ± 0.8	26.1 ± 0.9	26.7 ± 0.7	25.4 ± 0.7	25.9 ± 0.9	26.9 ± 0.8	29.4 ± 1.4	31.6 ± 1.8	31.3 ± 1.3	31.4 ± 0.8
Hct (%)	UCO	26.2 ± 0.7	27.8 ± 1.1	28.2 ± 0.8	28.1 ± 0.7	27.4 ± 0.5^*	27.7 ± 0.8	29.0 ± 0.5^*	30.2 ± 2.2	33.6 ± 3.7	35.2 ± 4.4	30.5 ± 1.2
O₂ct (mmol/l)	Sham	3.6 ± 0.1	3.4 ± 0.1	3.3 ± 0.2	3.6 ± 0.1	3.2 ± 0.1	3.4 ± 0.2	3.7 ± 0.2	3.9 ± 0.1	3.9 ± 0.2	6.6 ± 2.7	3.3 ± 0.3
O₂ct (mmol/l)	UCO	3.6 ± 0.1	0.4 ± 0.1^*	0.5 ± 0.1^*	4.3 ± 0.3^*	3.6 ± 0.2	4.1 ± 0.2^*	4.5 ± 0.1^*	4.6 ± 0.2^*	4.6 ± 0.2^*	4.5 ± 0.2	4.2 ± 0.2^*
Lactate (mmol/l)	Sham	0.9 ± 0.1	0.9 ± 0.03	0.9 ± 0.1	0.9 ± 0.0	0.9 ± 0.0	1.0 ± 0.0	0.9 ± 0.1	0.8 ± 0.04	0.9 ± 0.0	0.8 ± 0.0	1.1 ± 0.1
Lactate (mmol/l)	UCO	0.8 ± 0.1	3.9 ± 0.2^*	6.2 ± 0.3^*	4.8 ± 0.7^*	3.0 ± 0.5^*	2.1 ± 0.2^*	1.5 ± 0.2^*	0.9 ± 0.1	0.7 ± 0.0^*	0.8 ± 0.0	0.8 ± 0.0
Glucose (mmol/l)	Sham	1.1 ± 0.1	1.0 ± 0.04	1.0 ± 0.1	1.2 ± 0.1	1.1 ± 0.1	1.2 ± 0.1	1.1 ± 0.1	1.0 ± 0.1	1.0 ± 0.1	0.8 ± 0.1	0.8 ± 0.1
Glucose (mmol/l)	UCO	1.0 ± 0.1	0.4 ± 0.1^*	0.6 ± 0.1^*	1.3 ± 0.1	1.3 ± 0.1	1.4 ± 0.1^*	1.4 ± 0.1^*	1.1 ± 0.1	0.9 ± 0.1	0.9 ± 0.1	0.9 ± 0.0

	Group	Baseline	UCO (5 min)	UCO (17 min)	+2 h	+4 h	+6 h	+1 day	+3 days	+7 days	+14 days	+21 days
pH	Sham	7.36 ± 0.01	7.36 ± 0.01	7.36 ± 0.01	7.36 ± 0.01	7.35 ± 0.01	7.35 ± 0.01	7.35 ± 0.01	7.34 ± 0.01	7.35 ± 0.01	7.34 ± 0.01	7.33 ± 0.01
pH	UCO	7.35 ± 0.01	7.03 ± 0.01^*	6.84 ± 0.01^*	7.29 ± 0.02^*	7.38 ± 0.01	7.40 ± 0.01^*	7.36 ± 0.01	7.36 ± 0.01	7.36 ± 0.01	7.35 ± 0.01	7.36 ± 0.01^*
p_aCO₂ (mmHg)	Sham	48.5 ± 0.7	47.1 ± 0.8	46.6 ± 0.8	47.3 ± 0.9	46.1 ± 1.1	46.7 ± 0.9	48.4 ± 0.7	48.4 ± 0.8	49.1 ± 0.8	48.6 ± 1.0	49.4 ± 1.2
p_aCO₂ (mmHg)	UCO	50.7 ± 1.4	99.7 ± 2.6^*	136.4 ± 6.0^*	47.8 ± 0.8	47.7 ± 1.1	48.5 ± 0.7	46.3 ± 1.4	46.8 ± 1.5	49.2 ± 1.8	50.6 ± 1.4	48.6 ± 1.1
p_aO₂ (mmHg)	Sham	25.6 ± 0.6	24.6 ± 0.7	24.3 ± 0.6	25.5 ± 0.7	24.9 ± 0.5	25.7 ± 0.7	26.2 ± 0.8	27.0 ± 0.7	25.3 ± 1.1	26.0 ± 1.4	22.6 ± 1.3
p_aO₂ (mmHg)	UCO	24.7 ± 0.8	6.6 ± 0.4^*	9.5 ± 1.2^*	27.2 ± 1.2	23.5 ± 1.0	25.4 ± 1.0	29.1 ± 1.0^*	31.1 ± 1.2^*	29.4 ± 1.5^*	28.4 ± 1.2	26.5 ± 1.8
Hct (%)	Sham	27.2 ± 0.7	26.2 ± 0.8	26.1 ± 0.9	26.7 ± 0.7	25.4 ± 0.7	25.9 ± 0.9	26.9 ± 0.8	29.4 ± 1.4	31.6 ± 1.8	31.3 ± 1.3	31.4 ± 0.8
Hct (%)	UCO	26.2 ± 0.7	27.8 ± 1.1	28.2 ± 0.8	28.1 ± 0.7	27.4 ± 0.5^*	27.7 ± 0.8	29.0 ± 0.5^*	30.2 ± 2.2	33.6 ± 3.7	35.2 ± 4.4	30.5 ± 1.2
O₂ct (mmol/l)	Sham	3.6 ± 0.1	3.4 ± 0.1	3.3 ± 0.2	3.6 ± 0.1	3.2 ± 0.1	3.4 ± 0.2	3.7 ± 0.2	3.9 ± 0.1	3.9 ± 0.2	6.6 ± 2.7	3.3 ± 0.3
O₂ct (mmol/l)	UCO	3.6 ± 0.1	0.4 ± 0.1^*	0.5 ± 0.1^*	4.3 ± 0.3^*	3.6 ± 0.2	4.1 ± 0.2^*	4.5 ± 0.1^*	4.6 ± 0.2^*	4.6 ± 0.2^*	4.5 ± 0.2	4.2 ± 0.2^*
Lactate (mmol/l)	Sham	0.9 ± 0.1	0.9 ± 0.03	0.9 ± 0.1	0.9 ± 0.0	0.9 ± 0.0	1.0 ± 0.0	0.9 ± 0.1	0.8 ± 0.04	0.9 ± 0.0	0.8 ± 0.0	1.1 ± 0.1
Lactate (mmol/l)	UCO	0.8 ± 0.1	3.9 ± 0.2^*	6.2 ± 0.3^*	4.8 ± 0.7^*	3.0 ± 0.5^*	2.1 ± 0.2^*	1.5 ± 0.2^*	0.9 ± 0.1	0.7 ± 0.0^*	0.8 ± 0.0	0.8 ± 0.0
Glucose (mmol/l)	Sham	1.1 ± 0.1	1.0 ± 0.04	1.0 ± 0.1	1.2 ± 0.1	1.1 ± 0.1	1.2 ± 0.1	1.1 ± 0.1	1.0 ± 0.1	1.0 ± 0.1	0.8 ± 0.1	0.8 ± 0.1
Glucose (mmol/l)	UCO	1.0 ± 0.1	0.4 ± 0.1^*	0.6 ± 0.1^*	1.3 ± 0.1	1.3 ± 0.1	1.4 ± 0.1^*	1.4 ± 0.1^*	1.1 ± 0.1	0.9 ± 0.1	0.9 ± 0.1	0.9 ± 0.0

p_aCO_2, arterial partial pressure of carbon dioxide; p_aO_2, arterial partial pressure of oxygen; Hct, haematocrit; O₂ct; arterial oxygen content.

P < 0.05 sham versus UCO. Data are means ± SEM.

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