Table 1. Open in new tab Isogenic...

A. baumannii Mutants

Gene Description

Log₂ Fold Change (P Value) in ATCC 17978

References

Δ0242

feoA, ferrous iron transport protein A

1.16 (.0023)

[23]

Δ0781

mtnN, (MTA/SAH) nucleosidase

1.63 (9.04 × 10⁻⁹)

[24, 25]

Δ1657

bnfL, N-acetyltransferase, baumanoferrin biosynthesis protein

2.17 (5.06 × 10⁻⁰⁸)

[11, 26]

Δ2247

yfgC (bepA) putative periplasmic metalloprotease

2.06 (5.52 × 10⁻⁰⁵)

[27]

Δ2390

basB, acinetobactin biosynthesis protein

1.05 (.008)

[28, 29]

Δ3245

hisF, imidazole glycerol phosphate synthase cyclase subunit

2.86 (4.14 × 10⁻¹⁸)

[30]

Δ3410

oatA, acyltransferase

2.29 (1.20 × 10⁻⁰⁷)

[31, 32]

Δ0094

lrp regulon transcriptional regulator

3.53 (1.10 × 10⁻¹⁷)

[33]

Δ0315

DNA repair system (2-oxoglutarate-Fe (II)-oxygenase-like)

1.68 (.00022)

[34]

Δ0318

FusE-MFP/HlyD membrane fusion protein

2.10 (1.57 × 10⁻⁰⁷)

[35]

Δ0896

pilU, twitching motility

1.13 (.00635)

[36]

Δ1028

ligB, aromatic ring-opening dioxygenase

1.29 (.00326)

[37]

Δ3032

tonB-like, biological transducer activity

1.01 (3.63 × 10⁻⁰⁵)

[38]

Δ3290

esvF2, thiaminase (transcriptional activator TenA)

1.42 (.00034)

[39, 40]

Table 1.

Open in new tab

Isogenic Derivative Mutants of Acinetobacter baumannii ATCC 17978 Strain, Gene Names and Function of Product, Upregulated Expression During Lung Infection in ATCC 17978, and Previous Studies on the Implication of the Genes in Bacterial Virulence

A. baumannii Mutants	Gene Description	Log₂ Fold Change (P Value) in ATCC 17978	References
Δ0242	feoA, ferrous iron transport protein A	1.16 (.0023)	[23]
Δ0781	mtnN, (MTA/SAH) nucleosidase	1.63 (9.04 × 10⁻⁹)	[24, 25]
Δ1657	bnfL, N-acetyltransferase, baumanoferrin biosynthesis protein	2.17 (5.06 × 10⁻⁰⁸)	[11, 26]
Δ2247	yfgC (bepA) putative periplasmic metalloprotease	2.06 (5.52 × 10⁻⁰⁵)	[27]
Δ2390	basB, acinetobactin biosynthesis protein	1.05 (.008)	[28, 29]
Δ3245	hisF, imidazole glycerol phosphate synthase cyclase subunit	2.86 (4.14 × 10⁻¹⁸)	[30]
Δ3410	oatA, acyltransferase	2.29 (1.20 × 10⁻⁰⁷)	[31, 32]
Δ0094	lrp regulon transcriptional regulator	3.53 (1.10 × 10⁻¹⁷)	[33]
Δ0315	DNA repair system (2-oxoglutarate-Fe (II)-oxygenase-like)	1.68 (.00022)	[34]
Δ0318	FusE-MFP/HlyD membrane fusion protein	2.10 (1.57 × 10⁻⁰⁷)	[35]
Δ0896	pilU, twitching motility	1.13 (.00635)	[36]
Δ1028	ligB, aromatic ring-opening dioxygenase	1.29 (.00326)	[37]
Δ3032	tonB-like, biological transducer activity	1.01 (3.63 × 10⁻⁰⁵)	[38]
Δ3290	esvF2, thiaminase (transcriptional activator TenA)	1.42 (.00034)	[39, 40]

A. baumannii Mutants	Gene Description	Log₂ Fold Change (P Value) in ATCC 17978	References
Δ0242	feoA, ferrous iron transport protein A	1.16 (.0023)	[23]
Δ0781	mtnN, (MTA/SAH) nucleosidase	1.63 (9.04 × 10⁻⁹)	[24, 25]
Δ1657	bnfL, N-acetyltransferase, baumanoferrin biosynthesis protein	2.17 (5.06 × 10⁻⁰⁸)	[11, 26]
Δ2247	yfgC (bepA) putative periplasmic metalloprotease	2.06 (5.52 × 10⁻⁰⁵)	[27]
Δ2390	basB, acinetobactin biosynthesis protein	1.05 (.008)	[28, 29]
Δ3245	hisF, imidazole glycerol phosphate synthase cyclase subunit	2.86 (4.14 × 10⁻¹⁸)	[30]
Δ3410	oatA, acyltransferase	2.29 (1.20 × 10⁻⁰⁷)	[31, 32]
Δ0094	lrp regulon transcriptional regulator	3.53 (1.10 × 10⁻¹⁷)	[33]
Δ0315	DNA repair system (2-oxoglutarate-Fe (II)-oxygenase-like)	1.68 (.00022)	[34]
Δ0318	FusE-MFP/HlyD membrane fusion protein	2.10 (1.57 × 10⁻⁰⁷)	[35]
Δ0896	pilU, twitching motility	1.13 (.00635)	[36]
Δ1028	ligB, aromatic ring-opening dioxygenase	1.29 (.00326)	[37]
Δ3032	tonB-like, biological transducer activity	1.01 (3.63 × 10⁻⁰⁵)	[38]
Δ3290	esvF2, thiaminase (transcriptional activator TenA)	1.42 (.00034)	[39, 40]

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