Predictive Accuracy Metrics of Sepsis Criteria in Relation to 10-Day and 28-Day Mortality in Hematopoietic Cell Transplant Recipients With Suspected Infections
| Infection . | Sensitivitya, % (95% CI) . | Specificitya, % (95% CI) . | Youden Threshold . |
|---|---|---|---|
| All suspected infections | |||
| 10-day mortality | |||
| SIRS | 91.3 (72.0–98.9) | 35.0 (32.6–37.5) | 2 |
| qSOFA | 47.8 (26.8–69.4) | 90.5 (88.9–91.9) | 1 |
| NEWS | 78.3 (56.3–92.5) | 70.2 (67.8–72.4) | 8 |
| 28-day mortality | |||
| SIRS | 83.8 (73.4–91.3) | 35.5 (33.1–38.0) | 4 |
| qSOFA | 29.7 (19.7–41.5) | 90.9 (89.3–92.3) | 1 |
| NEWS | 64.9 (52.9–75.6) | 71.2 (68.8–73.4) | 7 |
| Inpatient suspected infections | |||
| 10-day mortality | |||
| SIRS | 88.2 (63.6–98.5) | 24.2 (21.4–27.1) | 2 |
| qSOFA | 52.9 (27.8–77.0) | 89.0 (86.7–91.0) | 2 |
| NEWS | 76.5 (50.1–93.2) | 65.9 (62.7–69.0) | 9 |
| 28-day mortality | |||
| SIRS | 87.5 (74.8–95.3) | 24.6 (21.7–27.6) | 4 |
| qSOFA | 37.5 (24.0–52.6) | 89.6 (87.4–91.6) | 1 |
| NEWS | 68.8 (53.7–81.3) | 67.0 (63.8–70.2) | 8 |
| Outpatient suspected infections | |||
| 10-day mortality | |||
| SIRS | 100 (54.1–100) | 49.8 (45.9–53.7) | 3 |
| qSOFA | 33.3 (4.3–77.7) | 92.5 (90.2–94.4) | 1 |
| NEWS | 83.3 (35.9–99.6) | 76.0 (72.5–79.2) | 8 |
| 28-day mortality | |||
| SIRS | 76.9 (56.4–91.0) | 50.4 (46.4–54.4) | 3 |
| qSOFA | 15.4 (4.4–34.9) | 92.6 (90.2–94.5) | 1 |
| NEWS | 57.7 (36.9–76.6) | 76.8 (73.3–80.0) | 5 |
| Infection . | Sensitivitya, % (95% CI) . | Specificitya, % (95% CI) . | Youden Threshold . |
|---|---|---|---|
| All suspected infections | |||
| 10-day mortality | |||
| SIRS | 91.3 (72.0–98.9) | 35.0 (32.6–37.5) | 2 |
| qSOFA | 47.8 (26.8–69.4) | 90.5 (88.9–91.9) | 1 |
| NEWS | 78.3 (56.3–92.5) | 70.2 (67.8–72.4) | 8 |
| 28-day mortality | |||
| SIRS | 83.8 (73.4–91.3) | 35.5 (33.1–38.0) | 4 |
| qSOFA | 29.7 (19.7–41.5) | 90.9 (89.3–92.3) | 1 |
| NEWS | 64.9 (52.9–75.6) | 71.2 (68.8–73.4) | 7 |
| Inpatient suspected infections | |||
| 10-day mortality | |||
| SIRS | 88.2 (63.6–98.5) | 24.2 (21.4–27.1) | 2 |
| qSOFA | 52.9 (27.8–77.0) | 89.0 (86.7–91.0) | 2 |
| NEWS | 76.5 (50.1–93.2) | 65.9 (62.7–69.0) | 9 |
| 28-day mortality | |||
| SIRS | 87.5 (74.8–95.3) | 24.6 (21.7–27.6) | 4 |
| qSOFA | 37.5 (24.0–52.6) | 89.6 (87.4–91.6) | 1 |
| NEWS | 68.8 (53.7–81.3) | 67.0 (63.8–70.2) | 8 |
| Outpatient suspected infections | |||
| 10-day mortality | |||
| SIRS | 100 (54.1–100) | 49.8 (45.9–53.7) | 3 |
| qSOFA | 33.3 (4.3–77.7) | 92.5 (90.2–94.4) | 1 |
| NEWS | 83.3 (35.9–99.6) | 76.0 (72.5–79.2) | 8 |
| 28-day mortality | |||
| SIRS | 76.9 (56.4–91.0) | 50.4 (46.4–54.4) | 3 |
| qSOFA | 15.4 (4.4–34.9) | 92.6 (90.2–94.5) | 1 |
| NEWS | 57.7 (36.9–76.6) | 76.8 (73.3–80.0) | 5 |
Abbreviations: CI, confidence interval; NEWS, National Early Warning Score; qSOFA, quick Sequential Organ Failure Assessment; SIRS, Systemic Inflammatory Response Syndrome.
aBased on the following prespecified cutpoints: SIRS ≥ 2, qSOFA ≥ 2, NEWS ≥ 7. CIs were estimated using the Clopper-Pearson method.
Predictive Accuracy Metrics of Sepsis Criteria in Relation to 10-Day and 28-Day Mortality in Hematopoietic Cell Transplant Recipients With Suspected Infections
| Infection . | Sensitivitya, % (95% CI) . | Specificitya, % (95% CI) . | Youden Threshold . |
|---|---|---|---|
| All suspected infections | |||
| 10-day mortality | |||
| SIRS | 91.3 (72.0–98.9) | 35.0 (32.6–37.5) | 2 |
| qSOFA | 47.8 (26.8–69.4) | 90.5 (88.9–91.9) | 1 |
| NEWS | 78.3 (56.3–92.5) | 70.2 (67.8–72.4) | 8 |
| 28-day mortality | |||
| SIRS | 83.8 (73.4–91.3) | 35.5 (33.1–38.0) | 4 |
| qSOFA | 29.7 (19.7–41.5) | 90.9 (89.3–92.3) | 1 |
| NEWS | 64.9 (52.9–75.6) | 71.2 (68.8–73.4) | 7 |
| Inpatient suspected infections | |||
| 10-day mortality | |||
| SIRS | 88.2 (63.6–98.5) | 24.2 (21.4–27.1) | 2 |
| qSOFA | 52.9 (27.8–77.0) | 89.0 (86.7–91.0) | 2 |
| NEWS | 76.5 (50.1–93.2) | 65.9 (62.7–69.0) | 9 |
| 28-day mortality | |||
| SIRS | 87.5 (74.8–95.3) | 24.6 (21.7–27.6) | 4 |
| qSOFA | 37.5 (24.0–52.6) | 89.6 (87.4–91.6) | 1 |
| NEWS | 68.8 (53.7–81.3) | 67.0 (63.8–70.2) | 8 |
| Outpatient suspected infections | |||
| 10-day mortality | |||
| SIRS | 100 (54.1–100) | 49.8 (45.9–53.7) | 3 |
| qSOFA | 33.3 (4.3–77.7) | 92.5 (90.2–94.4) | 1 |
| NEWS | 83.3 (35.9–99.6) | 76.0 (72.5–79.2) | 8 |
| 28-day mortality | |||
| SIRS | 76.9 (56.4–91.0) | 50.4 (46.4–54.4) | 3 |
| qSOFA | 15.4 (4.4–34.9) | 92.6 (90.2–94.5) | 1 |
| NEWS | 57.7 (36.9–76.6) | 76.8 (73.3–80.0) | 5 |
| Infection . | Sensitivitya, % (95% CI) . | Specificitya, % (95% CI) . | Youden Threshold . |
|---|---|---|---|
| All suspected infections | |||
| 10-day mortality | |||
| SIRS | 91.3 (72.0–98.9) | 35.0 (32.6–37.5) | 2 |
| qSOFA | 47.8 (26.8–69.4) | 90.5 (88.9–91.9) | 1 |
| NEWS | 78.3 (56.3–92.5) | 70.2 (67.8–72.4) | 8 |
| 28-day mortality | |||
| SIRS | 83.8 (73.4–91.3) | 35.5 (33.1–38.0) | 4 |
| qSOFA | 29.7 (19.7–41.5) | 90.9 (89.3–92.3) | 1 |
| NEWS | 64.9 (52.9–75.6) | 71.2 (68.8–73.4) | 7 |
| Inpatient suspected infections | |||
| 10-day mortality | |||
| SIRS | 88.2 (63.6–98.5) | 24.2 (21.4–27.1) | 2 |
| qSOFA | 52.9 (27.8–77.0) | 89.0 (86.7–91.0) | 2 |
| NEWS | 76.5 (50.1–93.2) | 65.9 (62.7–69.0) | 9 |
| 28-day mortality | |||
| SIRS | 87.5 (74.8–95.3) | 24.6 (21.7–27.6) | 4 |
| qSOFA | 37.5 (24.0–52.6) | 89.6 (87.4–91.6) | 1 |
| NEWS | 68.8 (53.7–81.3) | 67.0 (63.8–70.2) | 8 |
| Outpatient suspected infections | |||
| 10-day mortality | |||
| SIRS | 100 (54.1–100) | 49.8 (45.9–53.7) | 3 |
| qSOFA | 33.3 (4.3–77.7) | 92.5 (90.2–94.4) | 1 |
| NEWS | 83.3 (35.9–99.6) | 76.0 (72.5–79.2) | 8 |
| 28-day mortality | |||
| SIRS | 76.9 (56.4–91.0) | 50.4 (46.4–54.4) | 3 |
| qSOFA | 15.4 (4.4–34.9) | 92.6 (90.2–94.5) | 1 |
| NEWS | 57.7 (36.9–76.6) | 76.8 (73.3–80.0) | 5 |
Abbreviations: CI, confidence interval; NEWS, National Early Warning Score; qSOFA, quick Sequential Organ Failure Assessment; SIRS, Systemic Inflammatory Response Syndrome.
aBased on the following prespecified cutpoints: SIRS ≥ 2, qSOFA ≥ 2, NEWS ≥ 7. CIs were estimated using the Clopper-Pearson method.
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