Key Points
• The challenge of distinguishing pseudoprogression from progression leads to the early removal of patients from studies, curtailing our ability to evaluate the long-term benefits of immunotherapy
• Advanced MRI techniques including perfusion MRI, diffusion-weighted MRI, and iron-oxide or indium-labeled MRI may help to improve diagnostic decision-making
• The limitations of anatomic imaging have spurred exploration and development of novel imaging techniques, including MRS, metabolic pH with CEST, and novel PET probes
Key Points
• The challenge of distinguishing pseudoprogression from progression leads to the early removal of patients from studies, curtailing our ability to evaluate the long-term benefits of immunotherapy
• Advanced MRI techniques including perfusion MRI, diffusion-weighted MRI, and iron-oxide or indium-labeled MRI may help to improve diagnostic decision-making
• The limitations of anatomic imaging have spurred exploration and development of novel imaging techniques, including MRS, metabolic pH with CEST, and novel PET probes
Key Points
• The challenge of distinguishing pseudoprogression from progression leads to the early removal of patients from studies, curtailing our ability to evaluate the long-term benefits of immunotherapy
• Advanced MRI techniques including perfusion MRI, diffusion-weighted MRI, and iron-oxide or indium-labeled MRI may help to improve diagnostic decision-making
• The limitations of anatomic imaging have spurred exploration and development of novel imaging techniques, including MRS, metabolic pH with CEST, and novel PET probes
Key Points
• The challenge of distinguishing pseudoprogression from progression leads to the early removal of patients from studies, curtailing our ability to evaluate the long-term benefits of immunotherapy
• Advanced MRI techniques including perfusion MRI, diffusion-weighted MRI, and iron-oxide or indium-labeled MRI may help to improve diagnostic decision-making
• The limitations of anatomic imaging have spurred exploration and development of novel imaging techniques, including MRS, metabolic pH with CEST, and novel PET probes
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