Key Points
• A better understanding of glycolipid composition between healthy and malignant glial tissues as well as glycolipid synthesis pathways could be important for effective anti-tumor immune responses
• NKT cells are an understudied lymphocyte population that recognize lipid antigens and could play a role in the anti-tumor immune response. There is a need to understand the antigenic properties of these glycolipids for NKT-mediated recognition by the immune system
• Above approaches will likely need to be combined with other treatment modalities such as immune checkpoint blockade, vaccination, radiation therapy, and local chemotherapy
Key Points
• A better understanding of glycolipid composition between healthy and malignant glial tissues as well as glycolipid synthesis pathways could be important for effective anti-tumor immune responses
• NKT cells are an understudied lymphocyte population that recognize lipid antigens and could play a role in the anti-tumor immune response. There is a need to understand the antigenic properties of these glycolipids for NKT-mediated recognition by the immune system
• Above approaches will likely need to be combined with other treatment modalities such as immune checkpoint blockade, vaccination, radiation therapy, and local chemotherapy
Key Points
• A better understanding of glycolipid composition between healthy and malignant glial tissues as well as glycolipid synthesis pathways could be important for effective anti-tumor immune responses
• NKT cells are an understudied lymphocyte population that recognize lipid antigens and could play a role in the anti-tumor immune response. There is a need to understand the antigenic properties of these glycolipids for NKT-mediated recognition by the immune system
• Above approaches will likely need to be combined with other treatment modalities such as immune checkpoint blockade, vaccination, radiation therapy, and local chemotherapy
Key Points
• A better understanding of glycolipid composition between healthy and malignant glial tissues as well as glycolipid synthesis pathways could be important for effective anti-tumor immune responses
• NKT cells are an understudied lymphocyte population that recognize lipid antigens and could play a role in the anti-tumor immune response. There is a need to understand the antigenic properties of these glycolipids for NKT-mediated recognition by the immune system
• Above approaches will likely need to be combined with other treatment modalities such as immune checkpoint blockade, vaccination, radiation therapy, and local chemotherapy
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