| Key Points . |
|---|
| • The appropriate migration and differentiation of DCs within the TME is critical for the priming of antigen-specific T-cell responses. There is a need for developing strategies to this end |
| • The adoptive transfer of hematopoietic stem cells may enhance the migration and differentiation of DCs within the TME |
| • There is a need to understand the contributions of microglia and astrocytes to the process of antigen presentation in the context of GBM tumors |
| • Gene delivery of Flt3L and/or GM-CSF to the TME may be employed to enhance differentiation of monocytes into APCs or recruit additional APCs |
| • Whether and how different APC populations drive T-cell exhaustion is unknown |
| • Development of models that accurately recapitulate and allow for robust study of antigen presentation in glioma is needed |
| Key Points . |
|---|
| • The appropriate migration and differentiation of DCs within the TME is critical for the priming of antigen-specific T-cell responses. There is a need for developing strategies to this end |
| • The adoptive transfer of hematopoietic stem cells may enhance the migration and differentiation of DCs within the TME |
| • There is a need to understand the contributions of microglia and astrocytes to the process of antigen presentation in the context of GBM tumors |
| • Gene delivery of Flt3L and/or GM-CSF to the TME may be employed to enhance differentiation of monocytes into APCs or recruit additional APCs |
| • Whether and how different APC populations drive T-cell exhaustion is unknown |
| • Development of models that accurately recapitulate and allow for robust study of antigen presentation in glioma is needed |
| Key Points . |
|---|
| • The appropriate migration and differentiation of DCs within the TME is critical for the priming of antigen-specific T-cell responses. There is a need for developing strategies to this end |
| • The adoptive transfer of hematopoietic stem cells may enhance the migration and differentiation of DCs within the TME |
| • There is a need to understand the contributions of microglia and astrocytes to the process of antigen presentation in the context of GBM tumors |
| • Gene delivery of Flt3L and/or GM-CSF to the TME may be employed to enhance differentiation of monocytes into APCs or recruit additional APCs |
| • Whether and how different APC populations drive T-cell exhaustion is unknown |
| • Development of models that accurately recapitulate and allow for robust study of antigen presentation in glioma is needed |
| Key Points . |
|---|
| • The appropriate migration and differentiation of DCs within the TME is critical for the priming of antigen-specific T-cell responses. There is a need for developing strategies to this end |
| • The adoptive transfer of hematopoietic stem cells may enhance the migration and differentiation of DCs within the TME |
| • There is a need to understand the contributions of microglia and astrocytes to the process of antigen presentation in the context of GBM tumors |
| • Gene delivery of Flt3L and/or GM-CSF to the TME may be employed to enhance differentiation of monocytes into APCs or recruit additional APCs |
| • Whether and how different APC populations drive T-cell exhaustion is unknown |
| • Development of models that accurately recapitulate and allow for robust study of antigen presentation in glioma is needed |
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