| . | Arm A: RT Alone (N = 9) . | Arm B: RT + Concomitant TMZ (N = 11) . | Arm C: TMZ Alone (N = 9) . | Total (N = 29) . | P-value . |
|---|---|---|---|---|---|
| Median Days to Testing (range) | 87 (84–105) | 85 (73–130) | 82 (59–97) | 86 (59–130) | 0.13e |
| Frequency of Deteriorationa | |||||
| HVLT-R Immediate Recall, n (%) | 1 (11.1) | 1 (9.1) | 1 (11.1) | 3 (10.3) | 0.93d |
| COWAT, n (%) | 0 (0.0) | 1 (9.1) | 1 (11.1) | 2 (6.9) | 0.20d |
| Trail Making A, n (%) | 1 (12.5) | 0 (0.0) | 3 (37.5) | 4 (15.4) | 0.18d |
| Trail Making B, n (%) | 5 (71.4) | 3 (33.3) | 3 (42.9) | 11 (47.8) | 0.29d |
| HVLT-R Delayed Recall, n (%) | 3 (33.3) | 1 (9.1) | 0 (0.0) | 4 (14.3) | 0.18d |
| HVLT-R Delayed Recognition, n (%) | 2 (22.2) | 2 (18.2) | 1 (12.5) | 5 (17.9) | 0.24d |
| Progression Determination | |||||
| Neurocognitive Progressionb, n (%) | 7 (77.8) | 8 (72.7) | 6 (66.7) | 21 (72.4) | 0.87d |
| Clinical Progressionc, n (%) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | NA |
| . | Arm A: RT Alone (N = 9) . | Arm B: RT + Concomitant TMZ (N = 11) . | Arm C: TMZ Alone (N = 9) . | Total (N = 29) . | P-value . |
|---|---|---|---|---|---|
| Median Days to Testing (range) | 87 (84–105) | 85 (73–130) | 82 (59–97) | 86 (59–130) | 0.13e |
| Frequency of Deteriorationa | |||||
| HVLT-R Immediate Recall, n (%) | 1 (11.1) | 1 (9.1) | 1 (11.1) | 3 (10.3) | 0.93d |
| COWAT, n (%) | 0 (0.0) | 1 (9.1) | 1 (11.1) | 2 (6.9) | 0.20d |
| Trail Making A, n (%) | 1 (12.5) | 0 (0.0) | 3 (37.5) | 4 (15.4) | 0.18d |
| Trail Making B, n (%) | 5 (71.4) | 3 (33.3) | 3 (42.9) | 11 (47.8) | 0.29d |
| HVLT-R Delayed Recall, n (%) | 3 (33.3) | 1 (9.1) | 0 (0.0) | 4 (14.3) | 0.18d |
| HVLT-R Delayed Recognition, n (%) | 2 (22.2) | 2 (18.2) | 1 (12.5) | 5 (17.9) | 0.24d |
| Progression Determination | |||||
| Neurocognitive Progressionb, n (%) | 7 (77.8) | 8 (72.7) | 6 (66.7) | 21 (72.4) | 0.87d |
| Clinical Progressionc, n (%) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | NA |
RCI, reliable change index; HVLT-R, Hopkins Verbal Learning Test‒Revised; COWAT, Controlled Oral Word Association Test.
a>RCI90 value decrease from baseline.
bNumber deteriorating on any one subtest >RCI90 value decrease from baseline.
cDefined by clinical exam and/or radiographic progression at 3 months after registration.
dChi-square.
eKruskal–Wallis.
| . | Arm A: RT Alone (N = 9) . | Arm B: RT + Concomitant TMZ (N = 11) . | Arm C: TMZ Alone (N = 9) . | Total (N = 29) . | P-value . |
|---|---|---|---|---|---|
| Median Days to Testing (range) | 87 (84–105) | 85 (73–130) | 82 (59–97) | 86 (59–130) | 0.13e |
| Frequency of Deteriorationa | |||||
| HVLT-R Immediate Recall, n (%) | 1 (11.1) | 1 (9.1) | 1 (11.1) | 3 (10.3) | 0.93d |
| COWAT, n (%) | 0 (0.0) | 1 (9.1) | 1 (11.1) | 2 (6.9) | 0.20d |
| Trail Making A, n (%) | 1 (12.5) | 0 (0.0) | 3 (37.5) | 4 (15.4) | 0.18d |
| Trail Making B, n (%) | 5 (71.4) | 3 (33.3) | 3 (42.9) | 11 (47.8) | 0.29d |
| HVLT-R Delayed Recall, n (%) | 3 (33.3) | 1 (9.1) | 0 (0.0) | 4 (14.3) | 0.18d |
| HVLT-R Delayed Recognition, n (%) | 2 (22.2) | 2 (18.2) | 1 (12.5) | 5 (17.9) | 0.24d |
| Progression Determination | |||||
| Neurocognitive Progressionb, n (%) | 7 (77.8) | 8 (72.7) | 6 (66.7) | 21 (72.4) | 0.87d |
| Clinical Progressionc, n (%) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | NA |
| . | Arm A: RT Alone (N = 9) . | Arm B: RT + Concomitant TMZ (N = 11) . | Arm C: TMZ Alone (N = 9) . | Total (N = 29) . | P-value . |
|---|---|---|---|---|---|
| Median Days to Testing (range) | 87 (84–105) | 85 (73–130) | 82 (59–97) | 86 (59–130) | 0.13e |
| Frequency of Deteriorationa | |||||
| HVLT-R Immediate Recall, n (%) | 1 (11.1) | 1 (9.1) | 1 (11.1) | 3 (10.3) | 0.93d |
| COWAT, n (%) | 0 (0.0) | 1 (9.1) | 1 (11.1) | 2 (6.9) | 0.20d |
| Trail Making A, n (%) | 1 (12.5) | 0 (0.0) | 3 (37.5) | 4 (15.4) | 0.18d |
| Trail Making B, n (%) | 5 (71.4) | 3 (33.3) | 3 (42.9) | 11 (47.8) | 0.29d |
| HVLT-R Delayed Recall, n (%) | 3 (33.3) | 1 (9.1) | 0 (0.0) | 4 (14.3) | 0.18d |
| HVLT-R Delayed Recognition, n (%) | 2 (22.2) | 2 (18.2) | 1 (12.5) | 5 (17.9) | 0.24d |
| Progression Determination | |||||
| Neurocognitive Progressionb, n (%) | 7 (77.8) | 8 (72.7) | 6 (66.7) | 21 (72.4) | 0.87d |
| Clinical Progressionc, n (%) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | NA |
RCI, reliable change index; HVLT-R, Hopkins Verbal Learning Test‒Revised; COWAT, Controlled Oral Word Association Test.
a>RCI90 value decrease from baseline.
bNumber deteriorating on any one subtest >RCI90 value decrease from baseline.
cDefined by clinical exam and/or radiographic progression at 3 months after registration.
dChi-square.
eKruskal–Wallis.
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