Table 4.
Open in new tab

Findings according to the location of the lesion

Lesion in the CNS (n = 64)Lesion in the PNS and intrinsic to the larynx (n = 17)P value
Male sex, n (%)39 (60.4)7 (41.2)0.144
Age at disease onset, y57.7 ± 11.452.8 ± 20.50.155
Age at estimated stridor onset, y61.1 ± 10.958.4 ± 160.802
Stridor as the first manifestation, n (%)4 (6.2)0 (0)0.366
Age at V-PSG, y62 ± 10.560.9 ± 14.10.921
Inspiratory stridor, n (%)63 (98.4)17 (100)0.460
Expiratory stridor, n (%)7 (10.9)4 (23.5)0.178
AHI21.3 ± 18.522 ± 19.60.885
AHI >5, n (%)53 (82.8)15 (82.2)0.588
AHI >10, n (%)41 (64.1)11 (64.7)0.961
AHI >30, n (%)14 (21.9)5 (29.4)0.514
Obstructive apnea index, n19.7 ± 17.620.7 ± 20.40.903
Central apnea index, n1.6 ± 7.70.34 ± 0.50.212
CT90, n13.4 ± 20.94.5 ± 7.10.022
Nadir O2Hb, n83.7 ± 7.886 ± 5.20.353
Stridor during wakefulness, n (%)9 (14.1)4 (23.5)0.345
Laryngoscopy, n (%)55 (85.9)17 (100)0.101
Abnormal vocal cord mobility in laryngoscopy, n (%)51 (92.7)14 (82.3)0.207
 Vocal cord bilateral impairment, n (%)33 (64.7)9 (64.4)0.977
 Vocal cord unilateral impairment, n (%)18 (35.3)5 (35.7)0.977
 Vocal cord flickering, n (%)6 (11.8)0 (0)0.167
CPAP pressure, n8.7 ± 2.410.4 ± 1.30.035
Tracheostomy, n (%)16 (25)2 (11.8)0.243
Lesion in the CNS (n = 64)Lesion in the PNS and intrinsic to the larynx (n = 17)P value
Male sex, n (%)39 (60.4)7 (41.2)0.144
Age at disease onset, y57.7 ± 11.452.8 ± 20.50.155
Age at estimated stridor onset, y61.1 ± 10.958.4 ± 160.802
Stridor as the first manifestation, n (%)4 (6.2)0 (0)0.366
Age at V-PSG, y62 ± 10.560.9 ± 14.10.921
Inspiratory stridor, n (%)63 (98.4)17 (100)0.460
Expiratory stridor, n (%)7 (10.9)4 (23.5)0.178
AHI21.3 ± 18.522 ± 19.60.885
AHI >5, n (%)53 (82.8)15 (82.2)0.588
AHI >10, n (%)41 (64.1)11 (64.7)0.961
AHI >30, n (%)14 (21.9)5 (29.4)0.514
Obstructive apnea index, n19.7 ± 17.620.7 ± 20.40.903
Central apnea index, n1.6 ± 7.70.34 ± 0.50.212
CT90, n13.4 ± 20.94.5 ± 7.10.022
Nadir O2Hb, n83.7 ± 7.886 ± 5.20.353
Stridor during wakefulness, n (%)9 (14.1)4 (23.5)0.345
Laryngoscopy, n (%)55 (85.9)17 (100)0.101
Abnormal vocal cord mobility in laryngoscopy, n (%)51 (92.7)14 (82.3)0.207
 Vocal cord bilateral impairment, n (%)33 (64.7)9 (64.4)0.977
 Vocal cord unilateral impairment, n (%)18 (35.3)5 (35.7)0.977
 Vocal cord flickering, n (%)6 (11.8)0 (0)0.167
CPAP pressure, n8.7 ± 2.410.4 ± 1.30.035
Tracheostomy, n (%)16 (25)2 (11.8)0.243

CNS, central nervous system; PNS, peripheral nervous system; V-PSG, video-polysomnography; AHI, apnea–hypopnea index; CT90, percentatge of total sleep time with oxyhemoglobin saturation below 90; O2Hb, oxyhemoglobin saturation; CPAP, continuous positive airway pressure.

Table 4.
Open in new tab

Findings according to the location of the lesion

Lesion in the CNS (n = 64)Lesion in the PNS and intrinsic to the larynx (n = 17)P value
Male sex, n (%)39 (60.4)7 (41.2)0.144
Age at disease onset, y57.7 ± 11.452.8 ± 20.50.155
Age at estimated stridor onset, y61.1 ± 10.958.4 ± 160.802
Stridor as the first manifestation, n (%)4 (6.2)0 (0)0.366
Age at V-PSG, y62 ± 10.560.9 ± 14.10.921
Inspiratory stridor, n (%)63 (98.4)17 (100)0.460
Expiratory stridor, n (%)7 (10.9)4 (23.5)0.178
AHI21.3 ± 18.522 ± 19.60.885
AHI >5, n (%)53 (82.8)15 (82.2)0.588
AHI >10, n (%)41 (64.1)11 (64.7)0.961
AHI >30, n (%)14 (21.9)5 (29.4)0.514
Obstructive apnea index, n19.7 ± 17.620.7 ± 20.40.903
Central apnea index, n1.6 ± 7.70.34 ± 0.50.212
CT90, n13.4 ± 20.94.5 ± 7.10.022
Nadir O2Hb, n83.7 ± 7.886 ± 5.20.353
Stridor during wakefulness, n (%)9 (14.1)4 (23.5)0.345
Laryngoscopy, n (%)55 (85.9)17 (100)0.101
Abnormal vocal cord mobility in laryngoscopy, n (%)51 (92.7)14 (82.3)0.207
 Vocal cord bilateral impairment, n (%)33 (64.7)9 (64.4)0.977
 Vocal cord unilateral impairment, n (%)18 (35.3)5 (35.7)0.977
 Vocal cord flickering, n (%)6 (11.8)0 (0)0.167
CPAP pressure, n8.7 ± 2.410.4 ± 1.30.035
Tracheostomy, n (%)16 (25)2 (11.8)0.243
Lesion in the CNS (n = 64)Lesion in the PNS and intrinsic to the larynx (n = 17)P value
Male sex, n (%)39 (60.4)7 (41.2)0.144
Age at disease onset, y57.7 ± 11.452.8 ± 20.50.155
Age at estimated stridor onset, y61.1 ± 10.958.4 ± 160.802
Stridor as the first manifestation, n (%)4 (6.2)0 (0)0.366
Age at V-PSG, y62 ± 10.560.9 ± 14.10.921
Inspiratory stridor, n (%)63 (98.4)17 (100)0.460
Expiratory stridor, n (%)7 (10.9)4 (23.5)0.178
AHI21.3 ± 18.522 ± 19.60.885
AHI >5, n (%)53 (82.8)15 (82.2)0.588
AHI >10, n (%)41 (64.1)11 (64.7)0.961
AHI >30, n (%)14 (21.9)5 (29.4)0.514
Obstructive apnea index, n19.7 ± 17.620.7 ± 20.40.903
Central apnea index, n1.6 ± 7.70.34 ± 0.50.212
CT90, n13.4 ± 20.94.5 ± 7.10.022
Nadir O2Hb, n83.7 ± 7.886 ± 5.20.353
Stridor during wakefulness, n (%)9 (14.1)4 (23.5)0.345
Laryngoscopy, n (%)55 (85.9)17 (100)0.101
Abnormal vocal cord mobility in laryngoscopy, n (%)51 (92.7)14 (82.3)0.207
 Vocal cord bilateral impairment, n (%)33 (64.7)9 (64.4)0.977
 Vocal cord unilateral impairment, n (%)18 (35.3)5 (35.7)0.977
 Vocal cord flickering, n (%)6 (11.8)0 (0)0.167
CPAP pressure, n8.7 ± 2.410.4 ± 1.30.035
Tracheostomy, n (%)16 (25)2 (11.8)0.243

CNS, central nervous system; PNS, peripheral nervous system; V-PSG, video-polysomnography; AHI, apnea–hypopnea index; CT90, percentatge of total sleep time with oxyhemoglobin saturation below 90; O2Hb, oxyhemoglobin saturation; CPAP, continuous positive airway pressure.

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