Table 4.

Comparison of Metabolic Characteristics in Patients With CGL1 and CGL2

CGL1 (n = 16)CGL2 (n = 11)P Value
Age22 (11–31)11 (3–19).054
Gender (F/M)10/6 (F: 62.5%)5/6 (F: 45.5%).452
Diabetes9 (56.3%)5 (45.5%).704
The median age when diabetes develops17 (12–37)15 (7.5–17.5).19
Hypertriglyceridemia12 (75%)11 (100%).123
The median age when hypertriglyceridemia detected14 (10–26)1 (0.5–11).003
Low HDL cholesterol15 (93.8%)10 (90.9%).786
Hepatic steatosis15 (93.8%)10 (90.9%).786
The median age when hepatic steatosis detected16 (10–29)3.5 (0.5–13).007
Elevated liver enzymes4 (25%)9 (81.8%).006
Cirrhosis02 (18.2%).138
Pancreatitis3 (18.8%)0.248
Retinopathy5 (31.3%)2 (18.2%).662
Nephropathy8 (50%)4 (36.4%).696
Neuropathy5 (31.3%)1 (9.1%).35
Atherosclerosis3 (18.8%)0.248
Glucose (mmol/liter)7.11 (5.09–12.25)5.11 (4.56–8).076
HbA1c (%)7 (5.5–9.7)5.9 (4.9–8.2).251
HOMA score8.11 (3.47–16.39)12.46 (3.75–29.42).331
Triglyceride (mmol/liter)6.01 (1.86–13.81)4.58 (2.88–7.64).882
Total cholesterol (mmol/liter)4.42 (3.83–6.01)4.24 (3.64–5.92).748
LDL cholesterol (mmol/liter)2.16 (1.24–2.73)2.53 (1.73–3.93).183
HDL cholesterol (mmol/liter)0.75 (0.65–0.95)0.7 (0.41–0.86).277
ALT (IU/liter)28 (23–41)75 (60–109).003
AST (IU/liter)22 (17–33)43 (29–85).013
GGT (IU/liter)24 (14–70)85 (53–178).007
Leptin (ng/ml)0.74 (0.4–0.87)0.26 (0.1–0.57).008
Adiponectin (μg/ml)0.67 (0.39–1.43)11.77 (6.81–19.29)<.001
CGL1 (n = 16)CGL2 (n = 11)P Value
Age22 (11–31)11 (3–19).054
Gender (F/M)10/6 (F: 62.5%)5/6 (F: 45.5%).452
Diabetes9 (56.3%)5 (45.5%).704
The median age when diabetes develops17 (12–37)15 (7.5–17.5).19
Hypertriglyceridemia12 (75%)11 (100%).123
The median age when hypertriglyceridemia detected14 (10–26)1 (0.5–11).003
Low HDL cholesterol15 (93.8%)10 (90.9%).786
Hepatic steatosis15 (93.8%)10 (90.9%).786
The median age when hepatic steatosis detected16 (10–29)3.5 (0.5–13).007
Elevated liver enzymes4 (25%)9 (81.8%).006
Cirrhosis02 (18.2%).138
Pancreatitis3 (18.8%)0.248
Retinopathy5 (31.3%)2 (18.2%).662
Nephropathy8 (50%)4 (36.4%).696
Neuropathy5 (31.3%)1 (9.1%).35
Atherosclerosis3 (18.8%)0.248
Glucose (mmol/liter)7.11 (5.09–12.25)5.11 (4.56–8).076
HbA1c (%)7 (5.5–9.7)5.9 (4.9–8.2).251
HOMA score8.11 (3.47–16.39)12.46 (3.75–29.42).331
Triglyceride (mmol/liter)6.01 (1.86–13.81)4.58 (2.88–7.64).882
Total cholesterol (mmol/liter)4.42 (3.83–6.01)4.24 (3.64–5.92).748
LDL cholesterol (mmol/liter)2.16 (1.24–2.73)2.53 (1.73–3.93).183
HDL cholesterol (mmol/liter)0.75 (0.65–0.95)0.7 (0.41–0.86).277
ALT (IU/liter)28 (23–41)75 (60–109).003
AST (IU/liter)22 (17–33)43 (29–85).013
GGT (IU/liter)24 (14–70)85 (53–178).007
Leptin (ng/ml)0.74 (0.4–0.87)0.26 (0.1–0.57).008
Adiponectin (μg/ml)0.67 (0.39–1.43)11.77 (6.81–19.29)<.001

Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT: γ-glutamyl transferase; LDL, low-density lipoprotein; NASH, nonalcoholic steatohepatitis.

Data are presented as median (25th–75th percentiles).

Table 4.

Comparison of Metabolic Characteristics in Patients With CGL1 and CGL2

CGL1 (n = 16)CGL2 (n = 11)P Value
Age22 (11–31)11 (3–19).054
Gender (F/M)10/6 (F: 62.5%)5/6 (F: 45.5%).452
Diabetes9 (56.3%)5 (45.5%).704
The median age when diabetes develops17 (12–37)15 (7.5–17.5).19
Hypertriglyceridemia12 (75%)11 (100%).123
The median age when hypertriglyceridemia detected14 (10–26)1 (0.5–11).003
Low HDL cholesterol15 (93.8%)10 (90.9%).786
Hepatic steatosis15 (93.8%)10 (90.9%).786
The median age when hepatic steatosis detected16 (10–29)3.5 (0.5–13).007
Elevated liver enzymes4 (25%)9 (81.8%).006
Cirrhosis02 (18.2%).138
Pancreatitis3 (18.8%)0.248
Retinopathy5 (31.3%)2 (18.2%).662
Nephropathy8 (50%)4 (36.4%).696
Neuropathy5 (31.3%)1 (9.1%).35
Atherosclerosis3 (18.8%)0.248
Glucose (mmol/liter)7.11 (5.09–12.25)5.11 (4.56–8).076
HbA1c (%)7 (5.5–9.7)5.9 (4.9–8.2).251
HOMA score8.11 (3.47–16.39)12.46 (3.75–29.42).331
Triglyceride (mmol/liter)6.01 (1.86–13.81)4.58 (2.88–7.64).882
Total cholesterol (mmol/liter)4.42 (3.83–6.01)4.24 (3.64–5.92).748
LDL cholesterol (mmol/liter)2.16 (1.24–2.73)2.53 (1.73–3.93).183
HDL cholesterol (mmol/liter)0.75 (0.65–0.95)0.7 (0.41–0.86).277
ALT (IU/liter)28 (23–41)75 (60–109).003
AST (IU/liter)22 (17–33)43 (29–85).013
GGT (IU/liter)24 (14–70)85 (53–178).007
Leptin (ng/ml)0.74 (0.4–0.87)0.26 (0.1–0.57).008
Adiponectin (μg/ml)0.67 (0.39–1.43)11.77 (6.81–19.29)<.001
CGL1 (n = 16)CGL2 (n = 11)P Value
Age22 (11–31)11 (3–19).054
Gender (F/M)10/6 (F: 62.5%)5/6 (F: 45.5%).452
Diabetes9 (56.3%)5 (45.5%).704
The median age when diabetes develops17 (12–37)15 (7.5–17.5).19
Hypertriglyceridemia12 (75%)11 (100%).123
The median age when hypertriglyceridemia detected14 (10–26)1 (0.5–11).003
Low HDL cholesterol15 (93.8%)10 (90.9%).786
Hepatic steatosis15 (93.8%)10 (90.9%).786
The median age when hepatic steatosis detected16 (10–29)3.5 (0.5–13).007
Elevated liver enzymes4 (25%)9 (81.8%).006
Cirrhosis02 (18.2%).138
Pancreatitis3 (18.8%)0.248
Retinopathy5 (31.3%)2 (18.2%).662
Nephropathy8 (50%)4 (36.4%).696
Neuropathy5 (31.3%)1 (9.1%).35
Atherosclerosis3 (18.8%)0.248
Glucose (mmol/liter)7.11 (5.09–12.25)5.11 (4.56–8).076
HbA1c (%)7 (5.5–9.7)5.9 (4.9–8.2).251
HOMA score8.11 (3.47–16.39)12.46 (3.75–29.42).331
Triglyceride (mmol/liter)6.01 (1.86–13.81)4.58 (2.88–7.64).882
Total cholesterol (mmol/liter)4.42 (3.83–6.01)4.24 (3.64–5.92).748
LDL cholesterol (mmol/liter)2.16 (1.24–2.73)2.53 (1.73–3.93).183
HDL cholesterol (mmol/liter)0.75 (0.65–0.95)0.7 (0.41–0.86).277
ALT (IU/liter)28 (23–41)75 (60–109).003
AST (IU/liter)22 (17–33)43 (29–85).013
GGT (IU/liter)24 (14–70)85 (53–178).007
Leptin (ng/ml)0.74 (0.4–0.87)0.26 (0.1–0.57).008
Adiponectin (μg/ml)0.67 (0.39–1.43)11.77 (6.81–19.29)<.001

Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT: γ-glutamyl transferase; LDL, low-density lipoprotein; NASH, nonalcoholic steatohepatitis.

Data are presented as median (25th–75th percentiles).

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