Cisplatin-induced AKI: impact of RBT-3 preconditioning 3 days after cisplatin injection
| Group . | BUN (mg/dL) . | Creatinine (mg/dL) . | Plasma NAG (activity units/L) . | Renal NGAL (ng/mg protein) . | Plasma NGAL (ng/mg protein) . | Tissue cisplatin (µg/g tissue wet weight) . |
|---|---|---|---|---|---|---|
| Cisplatin | 105 ± 11 | 0.7 ± 0.1 | 19.5 ± 0.8 | 86 ± 18 | 1667 ± 360 | 227 ± 35 |
| Cisplatin/RBT-3 | 48 ± 5 | 0.43 ± 0.03 | 9.8 ± 1.2 | 28 ± 5 | 543 ± 160 | 142 ± 9 |
| P-value | <0.001 | <0.001 | 0.0025 | <0.04 | <0.05 | <0.05 |
| Normal values | 24 ± 1 | 0.3 ± 0.03 | 8.9 ± 2.0 | 7 ± 0.2 | 48 ± 6 | 0 |
| Group . | BUN (mg/dL) . | Creatinine (mg/dL) . | Plasma NAG (activity units/L) . | Renal NGAL (ng/mg protein) . | Plasma NGAL (ng/mg protein) . | Tissue cisplatin (µg/g tissue wet weight) . |
|---|---|---|---|---|---|---|
| Cisplatin | 105 ± 11 | 0.7 ± 0.1 | 19.5 ± 0.8 | 86 ± 18 | 1667 ± 360 | 227 ± 35 |
| Cisplatin/RBT-3 | 48 ± 5 | 0.43 ± 0.03 | 9.8 ± 1.2 | 28 ± 5 | 543 ± 160 | 142 ± 9 |
| P-value | <0.001 | <0.001 | 0.0025 | <0.04 | <0.05 | <0.05 |
| Normal values | 24 ± 1 | 0.3 ± 0.03 | 8.9 ± 2.0 | 7 ± 0.2 | 48 ± 6 | 0 |
The values are presented as mean ± SEM. Statistical comparisons were made by unpaired Student’s t-test. Plasma NAG and NGAL each significantly correlated with the BUN and plasma creatinine concentrations (see text).
Cisplatin-induced AKI: impact of RBT-3 preconditioning 3 days after cisplatin injection
| Group . | BUN (mg/dL) . | Creatinine (mg/dL) . | Plasma NAG (activity units/L) . | Renal NGAL (ng/mg protein) . | Plasma NGAL (ng/mg protein) . | Tissue cisplatin (µg/g tissue wet weight) . |
|---|---|---|---|---|---|---|
| Cisplatin | 105 ± 11 | 0.7 ± 0.1 | 19.5 ± 0.8 | 86 ± 18 | 1667 ± 360 | 227 ± 35 |
| Cisplatin/RBT-3 | 48 ± 5 | 0.43 ± 0.03 | 9.8 ± 1.2 | 28 ± 5 | 543 ± 160 | 142 ± 9 |
| P-value | <0.001 | <0.001 | 0.0025 | <0.04 | <0.05 | <0.05 |
| Normal values | 24 ± 1 | 0.3 ± 0.03 | 8.9 ± 2.0 | 7 ± 0.2 | 48 ± 6 | 0 |
| Group . | BUN (mg/dL) . | Creatinine (mg/dL) . | Plasma NAG (activity units/L) . | Renal NGAL (ng/mg protein) . | Plasma NGAL (ng/mg protein) . | Tissue cisplatin (µg/g tissue wet weight) . |
|---|---|---|---|---|---|---|
| Cisplatin | 105 ± 11 | 0.7 ± 0.1 | 19.5 ± 0.8 | 86 ± 18 | 1667 ± 360 | 227 ± 35 |
| Cisplatin/RBT-3 | 48 ± 5 | 0.43 ± 0.03 | 9.8 ± 1.2 | 28 ± 5 | 543 ± 160 | 142 ± 9 |
| P-value | <0.001 | <0.001 | 0.0025 | <0.04 | <0.05 | <0.05 |
| Normal values | 24 ± 1 | 0.3 ± 0.03 | 8.9 ± 2.0 | 7 ± 0.2 | 48 ± 6 | 0 |
The values are presented as mean ± SEM. Statistical comparisons were made by unpaired Student’s t-test. Plasma NAG and NGAL each significantly correlated with the BUN and plasma creatinine concentrations (see text).
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