Table 1.

The Role of Nicotine in Cigarette Design: Evidence of Patents and Corporate Documents

DateSourceDocument title or quotea
July 2, 1929Patent28Patent no. 1719291: Removing nicotine from tobacco. https://pdfpiw.uspto.gov/.piw?Docid=1719291&idkey=NONE&homeurl=http%3A%252F%252Fpatft.uspto.gov%252Fnetahtml%252FPTO%252Fpatimg.htm
May 7, 1935Patent29Patent no. 2000855: Method of denicotinizing tobacco. https://pdfpiw.uspto.gov/.piw?Docid=2000855&idkey=NONE&homeurl=http%3A%252F%252Fpatft.uspto.gov%252Fnetahtml%252FPTO%252Fpatimg.htm
December 9, 1935ATC30It is quite possible to “denicotinize” a cigarette by chemical and thermal methods. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/sxwv0024
November 2, 1959RJR31The physiological requirements of the smoker with respect to nicotine can be met by the application of the optimum amount of nicotine to the extracted tobacco. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/fxkp0034
July 17, 1963B&W32Moreover, nicotine is addictive. We are, then, in the business of selling nicotine, an addictive drug effective in the release of stress mechanisms. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/rhxp0042
September 18, 1963B&W33It may be well to remind you, however, that we have a research program in progress to obtain, by genetic means, any level of nicotine desired. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/jglw0200
February 1, 1965PM34Determine minimum nicotine required to keep human smoker “hooked.” https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/qynn0226
May 24, 1971RJR35Habituating level of nicotine (how low can we go?). https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/tjvk0191
April 14, 1972RJR36Research activities need to more precisely define the minimum amount of nicotine required for “satisfaction” in terms of dose levels, dose frequency, dosage form and the like. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/stdb0184
July 22, 1977Lorillard37The level of nicotine in the smoke required to produce the desired results is an unknown factor; however, we have estimated it to be in the neighborhood of 0.4–0.5 mg per cigarette. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/gxbv0035
June 30, 1978PM38For quite some time, we have been interested in finding out how smokers would react to cigarettes with normal levels of tar and very low levels of nicotine….The tobacco used to make these cigarettes was treated for 25 min with steam and ammonia to reduce the total alkaloids from 1.56% to 0.07%. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/srdv0184
February 13, 1980Lorillard39Determine the minimum level of nicotine that will allow continued smoking. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/kpmv0035
January 18, 1982PM40…a threshold [for nicotine effects] exists somewhere between 0.1 and 0.3 mgs of nicotine. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/tnbx0108
DateSourceDocument title or quotea
July 2, 1929Patent28Patent no. 1719291: Removing nicotine from tobacco. https://pdfpiw.uspto.gov/.piw?Docid=1719291&idkey=NONE&homeurl=http%3A%252F%252Fpatft.uspto.gov%252Fnetahtml%252FPTO%252Fpatimg.htm
May 7, 1935Patent29Patent no. 2000855: Method of denicotinizing tobacco. https://pdfpiw.uspto.gov/.piw?Docid=2000855&idkey=NONE&homeurl=http%3A%252F%252Fpatft.uspto.gov%252Fnetahtml%252FPTO%252Fpatimg.htm
December 9, 1935ATC30It is quite possible to “denicotinize” a cigarette by chemical and thermal methods. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/sxwv0024
November 2, 1959RJR31The physiological requirements of the smoker with respect to nicotine can be met by the application of the optimum amount of nicotine to the extracted tobacco. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/fxkp0034
July 17, 1963B&W32Moreover, nicotine is addictive. We are, then, in the business of selling nicotine, an addictive drug effective in the release of stress mechanisms. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/rhxp0042
September 18, 1963B&W33It may be well to remind you, however, that we have a research program in progress to obtain, by genetic means, any level of nicotine desired. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/jglw0200
February 1, 1965PM34Determine minimum nicotine required to keep human smoker “hooked.” https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/qynn0226
May 24, 1971RJR35Habituating level of nicotine (how low can we go?). https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/tjvk0191
April 14, 1972RJR36Research activities need to more precisely define the minimum amount of nicotine required for “satisfaction” in terms of dose levels, dose frequency, dosage form and the like. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/stdb0184
July 22, 1977Lorillard37The level of nicotine in the smoke required to produce the desired results is an unknown factor; however, we have estimated it to be in the neighborhood of 0.4–0.5 mg per cigarette. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/gxbv0035
June 30, 1978PM38For quite some time, we have been interested in finding out how smokers would react to cigarettes with normal levels of tar and very low levels of nicotine….The tobacco used to make these cigarettes was treated for 25 min with steam and ammonia to reduce the total alkaloids from 1.56% to 0.07%. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/srdv0184
February 13, 1980Lorillard39Determine the minimum level of nicotine that will allow continued smoking. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/kpmv0035
January 18, 1982PM40…a threshold [for nicotine effects] exists somewhere between 0.1 and 0.3 mgs of nicotine. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/tnbx0108

aLinks to U.S. patents and/or documents from the Truth Tobacco Industry Documents collection.

Table 1.

The Role of Nicotine in Cigarette Design: Evidence of Patents and Corporate Documents

DateSourceDocument title or quotea
July 2, 1929Patent28Patent no. 1719291: Removing nicotine from tobacco. https://pdfpiw.uspto.gov/.piw?Docid=1719291&idkey=NONE&homeurl=http%3A%252F%252Fpatft.uspto.gov%252Fnetahtml%252FPTO%252Fpatimg.htm
May 7, 1935Patent29Patent no. 2000855: Method of denicotinizing tobacco. https://pdfpiw.uspto.gov/.piw?Docid=2000855&idkey=NONE&homeurl=http%3A%252F%252Fpatft.uspto.gov%252Fnetahtml%252FPTO%252Fpatimg.htm
December 9, 1935ATC30It is quite possible to “denicotinize” a cigarette by chemical and thermal methods. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/sxwv0024
November 2, 1959RJR31The physiological requirements of the smoker with respect to nicotine can be met by the application of the optimum amount of nicotine to the extracted tobacco. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/fxkp0034
July 17, 1963B&W32Moreover, nicotine is addictive. We are, then, in the business of selling nicotine, an addictive drug effective in the release of stress mechanisms. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/rhxp0042
September 18, 1963B&W33It may be well to remind you, however, that we have a research program in progress to obtain, by genetic means, any level of nicotine desired. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/jglw0200
February 1, 1965PM34Determine minimum nicotine required to keep human smoker “hooked.” https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/qynn0226
May 24, 1971RJR35Habituating level of nicotine (how low can we go?). https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/tjvk0191
April 14, 1972RJR36Research activities need to more precisely define the minimum amount of nicotine required for “satisfaction” in terms of dose levels, dose frequency, dosage form and the like. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/stdb0184
July 22, 1977Lorillard37The level of nicotine in the smoke required to produce the desired results is an unknown factor; however, we have estimated it to be in the neighborhood of 0.4–0.5 mg per cigarette. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/gxbv0035
June 30, 1978PM38For quite some time, we have been interested in finding out how smokers would react to cigarettes with normal levels of tar and very low levels of nicotine….The tobacco used to make these cigarettes was treated for 25 min with steam and ammonia to reduce the total alkaloids from 1.56% to 0.07%. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/srdv0184
February 13, 1980Lorillard39Determine the minimum level of nicotine that will allow continued smoking. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/kpmv0035
January 18, 1982PM40…a threshold [for nicotine effects] exists somewhere between 0.1 and 0.3 mgs of nicotine. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/tnbx0108
DateSourceDocument title or quotea
July 2, 1929Patent28Patent no. 1719291: Removing nicotine from tobacco. https://pdfpiw.uspto.gov/.piw?Docid=1719291&idkey=NONE&homeurl=http%3A%252F%252Fpatft.uspto.gov%252Fnetahtml%252FPTO%252Fpatimg.htm
May 7, 1935Patent29Patent no. 2000855: Method of denicotinizing tobacco. https://pdfpiw.uspto.gov/.piw?Docid=2000855&idkey=NONE&homeurl=http%3A%252F%252Fpatft.uspto.gov%252Fnetahtml%252FPTO%252Fpatimg.htm
December 9, 1935ATC30It is quite possible to “denicotinize” a cigarette by chemical and thermal methods. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/sxwv0024
November 2, 1959RJR31The physiological requirements of the smoker with respect to nicotine can be met by the application of the optimum amount of nicotine to the extracted tobacco. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/fxkp0034
July 17, 1963B&W32Moreover, nicotine is addictive. We are, then, in the business of selling nicotine, an addictive drug effective in the release of stress mechanisms. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/rhxp0042
September 18, 1963B&W33It may be well to remind you, however, that we have a research program in progress to obtain, by genetic means, any level of nicotine desired. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/jglw0200
February 1, 1965PM34Determine minimum nicotine required to keep human smoker “hooked.” https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/qynn0226
May 24, 1971RJR35Habituating level of nicotine (how low can we go?). https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/tjvk0191
April 14, 1972RJR36Research activities need to more precisely define the minimum amount of nicotine required for “satisfaction” in terms of dose levels, dose frequency, dosage form and the like. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/stdb0184
July 22, 1977Lorillard37The level of nicotine in the smoke required to produce the desired results is an unknown factor; however, we have estimated it to be in the neighborhood of 0.4–0.5 mg per cigarette. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/gxbv0035
June 30, 1978PM38For quite some time, we have been interested in finding out how smokers would react to cigarettes with normal levels of tar and very low levels of nicotine….The tobacco used to make these cigarettes was treated for 25 min with steam and ammonia to reduce the total alkaloids from 1.56% to 0.07%. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/srdv0184
February 13, 1980Lorillard39Determine the minimum level of nicotine that will allow continued smoking. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/kpmv0035
January 18, 1982PM40…a threshold [for nicotine effects] exists somewhere between 0.1 and 0.3 mgs of nicotine. https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/tnbx0108

aLinks to U.S. patents and/or documents from the Truth Tobacco Industry Documents collection.

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