| Age at the baseline scan . | 60-70 . | 70-80 . | 80+ . |
|---|---|---|---|
| Age group characteristics | |||
| N, N (%) | 247 (45.00%) | 188 (34.00%) | 118 (21.00%) |
| Males, N (%) | 128 (51.80%) | 98 (52.10%) | 74 (62.70%) |
| Age, median (mad) | 65.00 (3.00) | 74.90 (3.70) | 84.50 (4.10) |
| Education (years), median (mad) | 16.00 (2.97) | 14.00 (2.97) | 14.50 (3.71) |
| APOE4 allele carrier, N (%) | 71 (28.70%) | 59 (31.40%) | 32 (27.10%) |
| APOE2 allele carrier, N (%) | 40 (16.2%) | 32 (17%) | 12 (10.20%) |
| Health, mean (SD) | 2.20 (0.90) | 2.10 (0.80) | 2.30 (0.90) |
| Baseline_CMC, mean (SD) | 1.70 (1.20) | 2.00 (1.30) | 2.90 (1.40) |
| Gait speed, median (mad) | 121.00 (15.86) | 114.00 (18.09) | 100.70 (20.76) |
| WMH/TIV × 100, median (mad) | 0.38% (0.24) | 0.82% (0.54) | 1.44% (0.91) |
| SPM12_PIB_RATIO, median (mad) | 1.39 (0.09) | 1.41 (0.15) | 1.56 (0.32) |
| Diagnosis and cognition | |||
| CU, N (%) | 230 (93.10%) | 161 (85.60%) | 95 (80.50%) |
| Global, median (mad) | 0.47 (0.83) | 0.05 (0.98) | −0.34 (0.94) |
| Memory, median (mad) | 0.45 (0.91) | 0.00 (1.15) | −0.36 (1.40) |
| Executive, median (mad) | 0.38 (0.77) | −0.02 (0.80) | −0.50 (0.99) |
| Language, median (mad) | 0.41 (0.90) | −0.04 (1.00) | −0.25 (0.88) |
| Visuospatial, median (mad) | 0.38 (0.85) | 0.12 (0.86) | 0.05 (0.93) |
| Age at the baseline scan . | 60-70 . | 70-80 . | 80+ . |
|---|---|---|---|
| Age group characteristics | |||
| N, N (%) | 247 (45.00%) | 188 (34.00%) | 118 (21.00%) |
| Males, N (%) | 128 (51.80%) | 98 (52.10%) | 74 (62.70%) |
| Age, median (mad) | 65.00 (3.00) | 74.90 (3.70) | 84.50 (4.10) |
| Education (years), median (mad) | 16.00 (2.97) | 14.00 (2.97) | 14.50 (3.71) |
| APOE4 allele carrier, N (%) | 71 (28.70%) | 59 (31.40%) | 32 (27.10%) |
| APOE2 allele carrier, N (%) | 40 (16.2%) | 32 (17%) | 12 (10.20%) |
| Health, mean (SD) | 2.20 (0.90) | 2.10 (0.80) | 2.30 (0.90) |
| Baseline_CMC, mean (SD) | 1.70 (1.20) | 2.00 (1.30) | 2.90 (1.40) |
| Gait speed, median (mad) | 121.00 (15.86) | 114.00 (18.09) | 100.70 (20.76) |
| WMH/TIV × 100, median (mad) | 0.38% (0.24) | 0.82% (0.54) | 1.44% (0.91) |
| SPM12_PIB_RATIO, median (mad) | 1.39 (0.09) | 1.41 (0.15) | 1.56 (0.32) |
| Diagnosis and cognition | |||
| CU, N (%) | 230 (93.10%) | 161 (85.60%) | 95 (80.50%) |
| Global, median (mad) | 0.47 (0.83) | 0.05 (0.98) | −0.34 (0.94) |
| Memory, median (mad) | 0.45 (0.91) | 0.00 (1.15) | −0.36 (1.40) |
| Executive, median (mad) | 0.38 (0.77) | −0.02 (0.80) | −0.50 (0.99) |
| Language, median (mad) | 0.41 (0.90) | −0.04 (1.00) | −0.25 (0.88) |
| Visuospatial, median (mad) | 0.38 (0.85) | 0.12 (0.86) | 0.05 (0.93) |
Main demographic, clinical and biomarker characteristics of the data set. Health, how healthy the participant feels from 0 to 4 with 4 being worst; CU, cognitively unimpaired; WMH/TIV × 100, WMH in T2 MRI as a fraction of total intra-cranial volume; SPM12_PIB_RATIO, Pittsburgh compound B (PiB) PET SUVR; mad, median absolute deviation. The last five domains that start with PZ refer to cognitive functionality; they are normative Z-values and higher values correspond to better cognitive score.
| Age at the baseline scan . | 60-70 . | 70-80 . | 80+ . |
|---|---|---|---|
| Age group characteristics | |||
| N, N (%) | 247 (45.00%) | 188 (34.00%) | 118 (21.00%) |
| Males, N (%) | 128 (51.80%) | 98 (52.10%) | 74 (62.70%) |
| Age, median (mad) | 65.00 (3.00) | 74.90 (3.70) | 84.50 (4.10) |
| Education (years), median (mad) | 16.00 (2.97) | 14.00 (2.97) | 14.50 (3.71) |
| APOE4 allele carrier, N (%) | 71 (28.70%) | 59 (31.40%) | 32 (27.10%) |
| APOE2 allele carrier, N (%) | 40 (16.2%) | 32 (17%) | 12 (10.20%) |
| Health, mean (SD) | 2.20 (0.90) | 2.10 (0.80) | 2.30 (0.90) |
| Baseline_CMC, mean (SD) | 1.70 (1.20) | 2.00 (1.30) | 2.90 (1.40) |
| Gait speed, median (mad) | 121.00 (15.86) | 114.00 (18.09) | 100.70 (20.76) |
| WMH/TIV × 100, median (mad) | 0.38% (0.24) | 0.82% (0.54) | 1.44% (0.91) |
| SPM12_PIB_RATIO, median (mad) | 1.39 (0.09) | 1.41 (0.15) | 1.56 (0.32) |
| Diagnosis and cognition | |||
| CU, N (%) | 230 (93.10%) | 161 (85.60%) | 95 (80.50%) |
| Global, median (mad) | 0.47 (0.83) | 0.05 (0.98) | −0.34 (0.94) |
| Memory, median (mad) | 0.45 (0.91) | 0.00 (1.15) | −0.36 (1.40) |
| Executive, median (mad) | 0.38 (0.77) | −0.02 (0.80) | −0.50 (0.99) |
| Language, median (mad) | 0.41 (0.90) | −0.04 (1.00) | −0.25 (0.88) |
| Visuospatial, median (mad) | 0.38 (0.85) | 0.12 (0.86) | 0.05 (0.93) |
| Age at the baseline scan . | 60-70 . | 70-80 . | 80+ . |
|---|---|---|---|
| Age group characteristics | |||
| N, N (%) | 247 (45.00%) | 188 (34.00%) | 118 (21.00%) |
| Males, N (%) | 128 (51.80%) | 98 (52.10%) | 74 (62.70%) |
| Age, median (mad) | 65.00 (3.00) | 74.90 (3.70) | 84.50 (4.10) |
| Education (years), median (mad) | 16.00 (2.97) | 14.00 (2.97) | 14.50 (3.71) |
| APOE4 allele carrier, N (%) | 71 (28.70%) | 59 (31.40%) | 32 (27.10%) |
| APOE2 allele carrier, N (%) | 40 (16.2%) | 32 (17%) | 12 (10.20%) |
| Health, mean (SD) | 2.20 (0.90) | 2.10 (0.80) | 2.30 (0.90) |
| Baseline_CMC, mean (SD) | 1.70 (1.20) | 2.00 (1.30) | 2.90 (1.40) |
| Gait speed, median (mad) | 121.00 (15.86) | 114.00 (18.09) | 100.70 (20.76) |
| WMH/TIV × 100, median (mad) | 0.38% (0.24) | 0.82% (0.54) | 1.44% (0.91) |
| SPM12_PIB_RATIO, median (mad) | 1.39 (0.09) | 1.41 (0.15) | 1.56 (0.32) |
| Diagnosis and cognition | |||
| CU, N (%) | 230 (93.10%) | 161 (85.60%) | 95 (80.50%) |
| Global, median (mad) | 0.47 (0.83) | 0.05 (0.98) | −0.34 (0.94) |
| Memory, median (mad) | 0.45 (0.91) | 0.00 (1.15) | −0.36 (1.40) |
| Executive, median (mad) | 0.38 (0.77) | −0.02 (0.80) | −0.50 (0.99) |
| Language, median (mad) | 0.41 (0.90) | −0.04 (1.00) | −0.25 (0.88) |
| Visuospatial, median (mad) | 0.38 (0.85) | 0.12 (0.86) | 0.05 (0.93) |
Main demographic, clinical and biomarker characteristics of the data set. Health, how healthy the participant feels from 0 to 4 with 4 being worst; CU, cognitively unimpaired; WMH/TIV × 100, WMH in T2 MRI as a fraction of total intra-cranial volume; SPM12_PIB_RATIO, Pittsburgh compound B (PiB) PET SUVR; mad, median absolute deviation. The last five domains that start with PZ refer to cognitive functionality; they are normative Z-values and higher values correspond to better cognitive score.
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