Table 1

Selected assays for tracking soluble and aggregated species of HTT

AnalyteHTRFAlphaLISAMSD
Total soluble mutant HTT

4C9-MW1

2B7-4C9

2B7-MW1

2B7-MW1

4C9-MW1

Soluble exon 1 HTT2B7-MW8

MW8-2B7

MW1-MW8

2B7-MW8

Soluble mutant HTT

(excluding exon 1 HTT)

MW1-MAB5490

MW1-MAB2166

MAB2166-MW1

MW1-MAB2166

MW1-MAB5490

Aggregated HTT

4C9-MW8

MW8-2B7

4C9-MW8

MAB2166-MW8

MW8-4C9

MW8-2B7

MW8-MAB5490

MW8-MAB2166

Total soluble full-length HTT

(mutant and wild type)

MAB5490-MAB2166

D7F7-MAB5490

MAB5490-MAB2166

MAB2166-MAB5490

None
AnalyteHTRFAlphaLISAMSD
Total soluble mutant HTT

4C9-MW1

2B7-4C9

2B7-MW1

2B7-MW1

4C9-MW1

Soluble exon 1 HTT2B7-MW8

MW8-2B7

MW1-MW8

2B7-MW8

Soluble mutant HTT

(excluding exon 1 HTT)

MW1-MAB5490

MW1-MAB2166

MAB2166-MW1

MW1-MAB2166

MW1-MAB5490

Aggregated HTT

4C9-MW8

MW8-2B7

4C9-MW8

MAB2166-MW8

MW8-4C9

MW8-2B7

MW8-MAB5490

MW8-MAB2166

Total soluble full-length HTT

(mutant and wild type)

MAB5490-MAB2166

D7F7-MAB5490

MAB5490-MAB2166

MAB2166-MAB5490

None
Table 1

Selected assays for tracking soluble and aggregated species of HTT

AnalyteHTRFAlphaLISAMSD
Total soluble mutant HTT

4C9-MW1

2B7-4C9

2B7-MW1

2B7-MW1

4C9-MW1

Soluble exon 1 HTT2B7-MW8

MW8-2B7

MW1-MW8

2B7-MW8

Soluble mutant HTT

(excluding exon 1 HTT)

MW1-MAB5490

MW1-MAB2166

MAB2166-MW1

MW1-MAB2166

MW1-MAB5490

Aggregated HTT

4C9-MW8

MW8-2B7

4C9-MW8

MAB2166-MW8

MW8-4C9

MW8-2B7

MW8-MAB5490

MW8-MAB2166

Total soluble full-length HTT

(mutant and wild type)

MAB5490-MAB2166

D7F7-MAB5490

MAB5490-MAB2166

MAB2166-MAB5490

None
AnalyteHTRFAlphaLISAMSD
Total soluble mutant HTT

4C9-MW1

2B7-4C9

2B7-MW1

2B7-MW1

4C9-MW1

Soluble exon 1 HTT2B7-MW8

MW8-2B7

MW1-MW8

2B7-MW8

Soluble mutant HTT

(excluding exon 1 HTT)

MW1-MAB5490

MW1-MAB2166

MAB2166-MW1

MW1-MAB2166

MW1-MAB5490

Aggregated HTT

4C9-MW8

MW8-2B7

4C9-MW8

MAB2166-MW8

MW8-4C9

MW8-2B7

MW8-MAB5490

MW8-MAB2166

Total soluble full-length HTT

(mutant and wild type)

MAB5490-MAB2166

D7F7-MAB5490

MAB5490-MAB2166

MAB2166-MAB5490

None
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