Table 1 Open in new tab Basic...

Parameters	CKD mice experiment	FMT experiment
BW (g)	41.2 ± 0.6	32.6 ± 0.9***	38.8 ± 0.6	41.0 ± 1.1	40.8 ± 0.5
Gastrocnemius muscle (mg)	306.2 ± 10.0	214.8 ± 7.6***	243.2 ± 6.7	300.6 ± 10.4^##	265.6 ± 8.0**
Soleus muscle (mg)	19.6 ± 0.8	13.3 ± 0.8***	13.3 ± 1.2	19.7 ± 1.1^##	16.5 ± 0.7*
Epididymal fat (mg)	626.0 ± 60.1	109.0 ± 35.6***	478.9.0 ± 33.0	815.4 ± 33.5^###	651.6 ± 24.4^### ***
UN (mg/dL)	24.5 ± 2.0	80.3 ± 6.5***	22.5 ± 1.8	18.5 ± 1.2	17.9 ± 1.1
Creatinine (mg/dL)	0.17 ± 0.02	0.56 ± 0.05***	0.11 ± 0.005	0.09 ± 0.004	0.10 ± 0.004
FBS (mg/dL)	141.4 ± 13.7	153.0 ± 13.6	169.0 ± 4.3	186.0 ± 8.7	186.8 ± 6.3
Insulin (ng/mL)	0.10 ± 0.03	0.34 ± 0.07**	0.20 ± 0.04	0.20 ± 0.08	0.20 ± 0.04
Aldosterone (pg/mL)	578.6 ± 136.6	2445.0 ± 481.4**	478.1 ± 94.3	487.5 ± 68.3	354.4 ± 45.1
Total protein (g/dL)	4.7 ± 0.09	4.5 ± 0.11	4.7 ± 0.12	4.5 ± 0.10	4.4 ± 0.12
TG (mg/dL)	71.4 ± 5.9	77.4 ± 8.6	48.9 ± 6.7	90.5 ± 9.3^##	90.5 ± 11.5^#
FFA (μEq/L)	1693.3 ± 68.1	1240.1 ± 84.3***	1202.4 ± 107.3	1461.9 ± 62.9	1351.1 ± 53.6
TC (mg/dL)	105.1 ± 4.6	142.4 ± 4.1***	117.9 ± 8.8	116.7 ± 5.2	117.3 ± 7.4

Parameters

CKD mice experiment

FMT experiment

Control

CKD

Vehicle

Control-FMT

CKD-FMT

BW (g)

41.2 ± 0.6

32.6 ± 0.9***

38.8 ± 0.6

41.0 ± 1.1

40.8 ± 0.5

Gastrocnemius muscle (mg)

306.2 ± 10.0

214.8 ± 7.6***

243.2 ± 6.7

300.6 ± 10.4^##

265.6 ± 8.0**

Soleus muscle (mg)

19.6 ± 0.8

13.3 ± 0.8***

13.3 ± 1.2

19.7 ± 1.1^##

16.5 ± 0.7*

Epididymal fat (mg)

626.0 ± 60.1

109.0 ± 35.6***

478.9.0 ± 33.0

815.4 ± 33.5^###

651.6 ± 24.4^### ***

UN (mg/dL)

24.5 ± 2.0

80.3 ± 6.5***

22.5 ± 1.8

18.5 ± 1.2

17.9 ± 1.1

Creatinine (mg/dL)

0.17 ± 0.02

0.56 ± 0.05***

0.11 ± 0.005

0.09 ± 0.004

0.10 ± 0.004

FBS (mg/dL)

141.4 ± 13.7

153.0 ± 13.6

169.0 ± 4.3

186.0 ± 8.7

186.8 ± 6.3

Insulin (ng/mL)

0.10 ± 0.03

0.34 ± 0.07**

0.20 ± 0.04

0.20 ± 0.08

0.20 ± 0.04

Aldosterone (pg/mL)

578.6 ± 136.6

2445.0 ± 481.4**

478.1 ± 94.3

487.5 ± 68.3

354.4 ± 45.1

Total protein (g/dL)

4.7 ± 0.09

4.5 ± 0.11

4.7 ± 0.12

4.5 ± 0.10

4.4 ± 0.12

TG (mg/dL)

71.4 ± 5.9

77.4 ± 8.6

48.9 ± 6.7

90.5 ± 9.3^##

90.5 ± 11.5^#

FFA (μEq/L)

1693.3 ± 68.1

1240.1 ± 84.3***

1202.4 ± 107.3

1461.9 ± 62.9

1351.1 ± 53.6

TC (mg/dL)

105.1 ± 4.6

142.4 ± 4.1***

117.9 ± 8.8

116.7 ± 5.2

117.3 ± 7.4

Parameters	CKD mice experiment	FMT experiment
BW (g)	41.2 ± 0.6	32.6 ± 0.9***	38.8 ± 0.6	41.0 ± 1.1	40.8 ± 0.5
Gastrocnemius muscle (mg)	306.2 ± 10.0	214.8 ± 7.6***	243.2 ± 6.7	300.6 ± 10.4^##	265.6 ± 8.0**
Soleus muscle (mg)	19.6 ± 0.8	13.3 ± 0.8***	13.3 ± 1.2	19.7 ± 1.1^##	16.5 ± 0.7*
Epididymal fat (mg)	626.0 ± 60.1	109.0 ± 35.6***	478.9.0 ± 33.0	815.4 ± 33.5^###	651.6 ± 24.4^### ***
UN (mg/dL)	24.5 ± 2.0	80.3 ± 6.5***	22.5 ± 1.8	18.5 ± 1.2	17.9 ± 1.1
Creatinine (mg/dL)	0.17 ± 0.02	0.56 ± 0.05***	0.11 ± 0.005	0.09 ± 0.004	0.10 ± 0.004
FBS (mg/dL)	141.4 ± 13.7	153.0 ± 13.6	169.0 ± 4.3	186.0 ± 8.7	186.8 ± 6.3
Insulin (ng/mL)	0.10 ± 0.03	0.34 ± 0.07**	0.20 ± 0.04	0.20 ± 0.08	0.20 ± 0.04
Aldosterone (pg/mL)	578.6 ± 136.6	2445.0 ± 481.4**	478.1 ± 94.3	487.5 ± 68.3	354.4 ± 45.1
Total protein (g/dL)	4.7 ± 0.09	4.5 ± 0.11	4.7 ± 0.12	4.5 ± 0.10	4.4 ± 0.12
TG (mg/dL)	71.4 ± 5.9	77.4 ± 8.6	48.9 ± 6.7	90.5 ± 9.3^##	90.5 ± 11.5^#
FFA (μEq/L)	1693.3 ± 68.1	1240.1 ± 84.3***	1202.4 ± 107.3	1461.9 ± 62.9	1351.1 ± 53.6
TC (mg/dL)	105.1 ± 4.6	142.4 ± 4.1***	117.9 ± 8.8	116.7 ± 5.2	117.3 ± 7.4

Table 1

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Basic characteristics of control and adenine-induced CKD mice or vehicle, control-FMT and CKD-FMT mice

Parameters	CKD mice experiment		FMT experiment
Parameters	Control	CKD	Vehicle	Control-FMT	CKD-FMT
BW (g)	41.2 ± 0.6	32.6 ± 0.9***	38.8 ± 0.6	41.0 ± 1.1	40.8 ± 0.5
Gastrocnemius muscle (mg)	306.2 ± 10.0	214.8 ± 7.6***	243.2 ± 6.7	300.6 ± 10.4^##	265.6 ± 8.0**
Soleus muscle (mg)	19.6 ± 0.8	13.3 ± 0.8***	13.3 ± 1.2	19.7 ± 1.1^##	16.5 ± 0.7*
Epididymal fat (mg)	626.0 ± 60.1	109.0 ± 35.6***	478.9.0 ± 33.0	815.4 ± 33.5^###	651.6 ± 24.4^### ***
UN (mg/dL)	24.5 ± 2.0	80.3 ± 6.5***	22.5 ± 1.8	18.5 ± 1.2	17.9 ± 1.1
Creatinine (mg/dL)	0.17 ± 0.02	0.56 ± 0.05***	0.11 ± 0.005	0.09 ± 0.004	0.10 ± 0.004
FBS (mg/dL)	141.4 ± 13.7	153.0 ± 13.6	169.0 ± 4.3	186.0 ± 8.7	186.8 ± 6.3
Insulin (ng/mL)	0.10 ± 0.03	0.34 ± 0.07**	0.20 ± 0.04	0.20 ± 0.08	0.20 ± 0.04
Aldosterone (pg/mL)	578.6 ± 136.6	2445.0 ± 481.4**	478.1 ± 94.3	487.5 ± 68.3	354.4 ± 45.1
Total protein (g/dL)	4.7 ± 0.09	4.5 ± 0.11	4.7 ± 0.12	4.5 ± 0.10	4.4 ± 0.12
TG (mg/dL)	71.4 ± 5.9	77.4 ± 8.6	48.9 ± 6.7	90.5 ± 9.3^##	90.5 ± 11.5^#
FFA (μEq/L)	1693.3 ± 68.1	1240.1 ± 84.3***	1202.4 ± 107.3	1461.9 ± 62.9	1351.1 ± 53.6
TC (mg/dL)	105.1 ± 4.6	142.4 ± 4.1***	117.9 ± 8.8	116.7 ± 5.2	117.3 ± 7.4

Parameters	CKD mice experiment		FMT experiment
Parameters	Control	CKD	Vehicle	Control-FMT	CKD-FMT
BW (g)	41.2 ± 0.6	32.6 ± 0.9***	38.8 ± 0.6	41.0 ± 1.1	40.8 ± 0.5
Gastrocnemius muscle (mg)	306.2 ± 10.0	214.8 ± 7.6***	243.2 ± 6.7	300.6 ± 10.4^##	265.6 ± 8.0**
Soleus muscle (mg)	19.6 ± 0.8	13.3 ± 0.8***	13.3 ± 1.2	19.7 ± 1.1^##	16.5 ± 0.7*
Epididymal fat (mg)	626.0 ± 60.1	109.0 ± 35.6***	478.9.0 ± 33.0	815.4 ± 33.5^###	651.6 ± 24.4^### ***
UN (mg/dL)	24.5 ± 2.0	80.3 ± 6.5***	22.5 ± 1.8	18.5 ± 1.2	17.9 ± 1.1
Creatinine (mg/dL)	0.17 ± 0.02	0.56 ± 0.05***	0.11 ± 0.005	0.09 ± 0.004	0.10 ± 0.004
FBS (mg/dL)	141.4 ± 13.7	153.0 ± 13.6	169.0 ± 4.3	186.0 ± 8.7	186.8 ± 6.3
Insulin (ng/mL)	0.10 ± 0.03	0.34 ± 0.07**	0.20 ± 0.04	0.20 ± 0.08	0.20 ± 0.04
Aldosterone (pg/mL)	578.6 ± 136.6	2445.0 ± 481.4**	478.1 ± 94.3	487.5 ± 68.3	354.4 ± 45.1
Total protein (g/dL)	4.7 ± 0.09	4.5 ± 0.11	4.7 ± 0.12	4.5 ± 0.10	4.4 ± 0.12
TG (mg/dL)	71.4 ± 5.9	77.4 ± 8.6	48.9 ± 6.7	90.5 ± 9.3^##	90.5 ± 11.5^#
FFA (μEq/L)	1693.3 ± 68.1	1240.1 ± 84.3***	1202.4 ± 107.3	1461.9 ± 62.9	1351.1 ± 53.6
TC (mg/dL)	105.1 ± 4.6	142.4 ± 4.1***	117.9 ± 8.8	116.7 ± 5.2	117.3 ± 7.4

Values presented as mean ± standard deviation.

P < 0.05,

P < 0.01,

###

P < 0.001 versus vehicle mice.

P < 0.05,

P < 0.01,

***

P < 0.001 versus control mice or control-FMT group.

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