Table 1 Open in new tab Baseline...

Characteristics	Overall	Baseline	Baseline
Patients, n	1834	486	1348
Age (years), median (IQR)	75 (67–80)	73 (64–78)	75 (68–81)
Male (%)	58	64	55
Body mass index^a (kg/m²), mean (SD)	29 (6)	29 (5)	29 (6)
Primary cause of CKD^a^,b (%)
Diabetes	30	25	32
Hypertensive renal disease	33	35	33
Glomerulonephritis	9	10	9
Hereditary disease	4	3	4
Tubulointerstitial disease	6	8	6
Other	17	20	16
Comorbidities (%)
Diabetes^a	42	39	42
Hypertension^a	85	86	85
Heart failure^a	13	9	14
Coronary artery disease^a	28	29	28
Cerebrovascular disease^a	11	12	11
Peripheral vascular disease^a	20	16	21
eGFR (mL/min/1.73 m²), median (IQR)	25 (21–31)	40 (35–48)	23 (19–26)
Albuminuria^c (%)
Normal to mildly increased	19	27	16
Moderately increased	17	17	17
Very high	13	12	13
Nephrotic range	6	3	7
Missing	45	41	47
Haemoglobin^a (g/dL), mean (SD)	12 (2)	13 (2)	12 (2)
Parathyroid hormone^d (pg/mL), median (IQR)	103 (66–170)	70 (49–100)	118 (78–199)
Phosphate^e (mg/dl), mean (SD)	3.69 (0.76)	3.30 (0.66)	3.83 (0.75)
Calcium^f (mg/dl), mean (SD)	9.27 (0.63)	9.39 (0.53)	9.22 (0.65)
SBP^g (mmHg), mean (SD)	139 (19)	136 (18)	139 (20)
DBP^g (mmHg), mean (SD)	76 (11)	76 (11)	76 (11)
RAASi prescription^g (%)	79	80	78
Statin prescription^g (%)	52	56	51

Characteristics

Overall

Baseline

eGFR ≥30 mL/min/1.73 m²

eGFR <30 mL/min/1.73 m²

Patients, n

1834

486

1348

Age (years), median (IQR)

75 (67–80)

73 (64–78)

75 (68–81)

Male (%)

Body mass index^a (kg/m²), mean (SD)

29 (6)

29 (5)

29 (6)

Primary cause of CKD^a^,b (%)

Diabetes

Hypertensive renal disease

Glomerulonephritis

Hereditary disease

Tubulointerstitial disease

Other

Comorbidities (%)

Diabetes^a

Hypertension^a

Heart failure^a

Coronary artery disease^a

Cerebrovascular disease^a

Peripheral vascular disease^a

eGFR (mL/min/1.73 m²), median (IQR)

25 (21–31)

40 (35–48)

23 (19–26)

Albuminuria^c (%)

Normal to mildly increased

Moderately increased

Very high

Nephrotic range

Missing

Haemoglobin^a (g/dL), mean (SD)

12 (2)

13 (2)

12 (2)

Parathyroid hormone^d (pg/mL), median (IQR)

103 (66–170)

70 (49–100)

118 (78–199)

Phosphate^e (mg/dl), mean (SD)

3.69 (0.76)

3.30 (0.66)

3.83 (0.75)

Calcium^f (mg/dl), mean (SD)

9.27 (0.63)

9.39 (0.53)

9.22 (0.65)

SBP^g (mmHg), mean (SD)

139 (19)

136 (18)

139 (20)

DBP^g (mmHg), mean (SD)

76 (11)

RAASi prescription^g (%)

Statin prescription^g (%)

Characteristics	Overall	Baseline	Baseline
Patients, n	1834	486	1348
Age (years), median (IQR)	75 (67–80)	73 (64–78)	75 (68–81)
Male (%)	58	64	55
Body mass index^a (kg/m²), mean (SD)	29 (6)	29 (5)	29 (6)
Primary cause of CKD^a^,b (%)
Diabetes	30	25	32
Hypertensive renal disease	33	35	33
Glomerulonephritis	9	10	9
Hereditary disease	4	3	4
Tubulointerstitial disease	6	8	6
Other	17	20	16
Comorbidities (%)
Diabetes^a	42	39	42
Hypertension^a	85	86	85
Heart failure^a	13	9	14
Coronary artery disease^a	28	29	28
Cerebrovascular disease^a	11	12	11
Peripheral vascular disease^a	20	16	21
eGFR (mL/min/1.73 m²), median (IQR)	25 (21–31)	40 (35–48)	23 (19–26)
Albuminuria^c (%)
Normal to mildly increased	19	27	16
Moderately increased	17	17	17
Very high	13	12	13
Nephrotic range	6	3	7
Missing	45	41	47
Haemoglobin^a (g/dL), mean (SD)	12 (2)	13 (2)	12 (2)
Parathyroid hormone^d (pg/mL), median (IQR)	103 (66–170)	70 (49–100)	118 (78–199)
Phosphate^e (mg/dl), mean (SD)	3.69 (0.76)	3.30 (0.66)	3.83 (0.75)
Calcium^f (mg/dl), mean (SD)	9.27 (0.63)	9.39 (0.53)	9.22 (0.65)
SBP^g (mmHg), mean (SD)	139 (19)	136 (18)	139 (20)
DBP^g (mmHg), mean (SD)	76 (11)	76 (11)	76 (11)
RAASi prescription^g (%)	79	80	78
Statin prescription^g (%)	52	56	51

Table 1

Open in new tab

Baseline demographic and clinical characteristics

Characteristics	Overall	Baseline	Baseline
Characteristics	Overall	eGFR ≥30 mL/min/1.73 m²	eGFR <30 mL/min/1.73 m²
Patients, n	1834	486	1348
Age (years), median (IQR)	75 (67–80)	73 (64–78)	75 (68–81)
Male (%)	58	64	55
Body mass index^a (kg/m²), mean (SD)	29 (6)	29 (5)	29 (6)
Primary cause of CKD^a^,b (%)
Diabetes	30	25	32
Hypertensive renal disease	33	35	33
Glomerulonephritis	9	10	9
Hereditary disease	4	3	4
Tubulointerstitial disease	6	8	6
Other	17	20	16
Comorbidities (%)
Diabetes^a	42	39	42
Hypertension^a	85	86	85
Heart failure^a	13	9	14
Coronary artery disease^a	28	29	28
Cerebrovascular disease^a	11	12	11
Peripheral vascular disease^a	20	16	21
eGFR (mL/min/1.73 m²), median (IQR)	25 (21–31)	40 (35–48)	23 (19–26)
Albuminuria^c (%)
Normal to mildly increased	19	27	16
Moderately increased	17	17	17
Very high	13	12	13
Nephrotic range	6	3	7
Missing	45	41	47
Haemoglobin^a (g/dL), mean (SD)	12 (2)	13 (2)	12 (2)
Parathyroid hormone^d (pg/mL), median (IQR)	103 (66–170)	70 (49–100)	118 (78–199)
Phosphate^e (mg/dl), mean (SD)	3.69 (0.76)	3.30 (0.66)	3.83 (0.75)
Calcium^f (mg/dl), mean (SD)	9.27 (0.63)	9.39 (0.53)	9.22 (0.65)
SBP^g (mmHg), mean (SD)	139 (19)	136 (18)	139 (20)
DBP^g (mmHg), mean (SD)	76 (11)	76 (11)	76 (11)
RAASi prescription^g (%)	79	80	78
Statin prescription^g (%)	52	56	51

Characteristics	Overall	Baseline	Baseline
Characteristics	Overall	eGFR ≥30 mL/min/1.73 m²	eGFR <30 mL/min/1.73 m²
Patients, n	1834	486	1348
Age (years), median (IQR)	75 (67–80)	73 (64–78)	75 (68–81)
Male (%)	58	64	55
Body mass index^a (kg/m²), mean (SD)	29 (6)	29 (5)	29 (6)
Primary cause of CKD^a^,b (%)
Diabetes	30	25	32
Hypertensive renal disease	33	35	33
Glomerulonephritis	9	10	9
Hereditary disease	4	3	4
Tubulointerstitial disease	6	8	6
Other	17	20	16
Comorbidities (%)
Diabetes^a	42	39	42
Hypertension^a	85	86	85
Heart failure^a	13	9	14
Coronary artery disease^a	28	29	28
Cerebrovascular disease^a	11	12	11
Peripheral vascular disease^a	20	16	21
eGFR (mL/min/1.73 m²), median (IQR)	25 (21–31)	40 (35–48)	23 (19–26)
Albuminuria^c (%)
Normal to mildly increased	19	27	16
Moderately increased	17	17	17
Very high	13	12	13
Nephrotic range	6	3	7
Missing	45	41	47
Haemoglobin^a (g/dL), mean (SD)	12 (2)	13 (2)	12 (2)
Parathyroid hormone^d (pg/mL), median (IQR)	103 (66–170)	70 (49–100)	118 (78–199)
Phosphate^e (mg/dl), mean (SD)	3.69 (0.76)	3.30 (0.66)	3.83 (0.75)
Calcium^f (mg/dl), mean (SD)	9.27 (0.63)	9.39 (0.53)	9.22 (0.65)
SBP^g (mmHg), mean (SD)	139 (19)	136 (18)	139 (20)
DBP^g (mmHg), mean (SD)	76 (11)	76 (11)	76 (11)
RAASi prescription^g (%)	79	80	78
Statin prescription^g (%)	52	56	51

1–10% missing.

According to attending physician.

Albuminuria categories from KDIGO 2012 guidelines [15], where moderately increased is albumin 30–300 mg/day, albumin:creatinine ratio 30–300 mg/g, protein 150–500 mg/day, protein:creatinine ratio 150–500 mg/g or trace to 1+ protein reagent strip and severely increased is split into very high (albumin 300–2000 mg/day, albumin:creatinine ratio 300–2000 mg/g, protein 500–3000 mg/day, protein:creatinine ratio 500–3000 mg/g or 2+ protein reagent strip) and nephrotic range (higher than very high ranges).

49% missing.

Phosphate: mg/dL × 0.3229 = mmol/l.

Calcium: mg/dL × 0.2495 = mmol/l.

11–20% missing.

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