Table 3. Open in new tab The...

30-day mortality	Univariate analysis	Multivariate analysis
Quartiles of UA
Q1 (UA⩽5.0 mg/dl)	1.000			1.000
Q2 (5.1 mg/dl⩽UA⩽6.2 mg/dl)	0.754	0.452–1.259	0.291	0.916	0.498–1.685	0.778
Q3 (6.3 mg/dl⩽UA⩽7.6 mg/dl)	1.738	1.126–2.683	0.013	1.375	0.807–2.344	0.241
Q4 (UA⩾7.7 mg/dl)	3.248	2.176–4.848	<0.001	1.856	1.140–3.022	0.013
Adjusting factors
Configuration factors of APACHE II score
GCS (per one-point increase)	1.263	1.230–1.297	<0.001	1.052	1.006–1.101	0.025
MBP (per one-point increase)	1.665	1.518–1.826	<0.001
Pulse (per one-point increase)	1.732	1.575–1.906	<0.001	1.151	1.014–1.307	0.030
Respiratory rate (per one-point increase)	1.954	1.801–2.121	<0.001	1.381	1.212–1.574	<0.001
Body temperature (per one-point increase)	2.071	1.705–2.515	<0.001	1.367	1.040–1.796	0.025
WBC (per one-point increase)	1.830	1.482–2.260	<0.001	1.402	1.065–1.845	0.016
Hematocrit (per one-point increase)	1.231	1.077–1.406	0.002
Creatinine (per one-point increase)	1.287	1.186–1.397	<0.001	1.265	1.130–1.416	<0.001
Sodium (per one-point increase)	1.896	1.511–2.381	<0.001	1.491	1.109–2.004	0.008
Potassium (per one-point increase)	1.556	1.395–1.736	<0.001
PO₂ (per one-point increase)	1.383	1.269–1.507	<0.001
pH (per one-point increase)	1.771	1.630–1.924	<0.001
Age (per one-point increase)	1.105	1.018–1.199	0.017	1.180	1.052–1.323	0.005
CHP (per one-point increase)	1.251	0.993–1.575	0.057	1.282	0.981–1.675	0.069
Treatment strategy
Performed CPR, yes	13.815	10.052–18.986	<0.001	1.751	1.017–3.014	0.043
Use of vasopressors, yes	12.235	9.032–16.574	<0.001	4.857	3.305–7.138	<0.001
Use of antibiotics, yes	2.355	1.817–3.052	<0.001

30-day mortality

Univariate analysis

Multivariate analysis

95% CI

p value

95% CI

p value

Quartiles of UA

Q1 (UA⩽5.0 mg/dl)

1.000

Q2 (5.1 mg/dl⩽UA⩽6.2 mg/dl)

0.754

0.452–1.259

0.291

0.916

0.498–1.685

0.778

Q3 (6.3 mg/dl⩽UA⩽7.6 mg/dl)

1.738

1.126–2.683

0.013

1.375

0.807–2.344

0.241

Q4 (UA⩾7.7 mg/dl)

3.248

2.176–4.848

<0.001

1.856

1.140–3.022

0.013

Adjusting factors

Configuration factors of APACHE II score

GCS (per one-point increase)

1.263

1.230–1.297

<0.001

1.052

1.006–1.101

0.025

MBP (per one-point increase)

1.665

1.518–1.826

<0.001

Pulse (per one-point increase)

1.732

1.575–1.906

<0.001

1.151

1.014–1.307

0.030

Respiratory rate (per one-point increase)

1.954

1.801–2.121

<0.001

1.381

1.212–1.574

<0.001

Body temperature (per one-point increase)

2.071

1.705–2.515

<0.001

1.367

1.040–1.796

0.025

WBC (per one-point increase)

1.830

1.482–2.260

<0.001

1.402

1.065–1.845

0.016

Hematocrit (per one-point increase)

1.231

1.077–1.406

0.002

Creatinine (per one-point increase)

1.287

1.186–1.397

<0.001

1.265

1.130–1.416

<0.001

Sodium (per one-point increase)

1.896

1.511–2.381

<0.001

1.491

1.109–2.004

0.008

Potassium (per one-point increase)

1.556

1.395–1.736

<0.001

PO₂ (per one-point increase)

1.383

1.269–1.507

<0.001

pH (per one-point increase)

1.771

1.630–1.924

<0.001

Age (per one-point increase)

1.105

1.018–1.199

0.017

1.180

1.052–1.323

0.005

CHP (per one-point increase)

1.251

0.993–1.575

0.057

1.282

0.981–1.675

0.069

Treatment strategy

Performed CPR, yes

13.815

10.052–18.986

<0.001

1.751

1.017–3.014

0.043

Use of vasopressors, yes

12.235

9.032–16.574

<0.001

4.857

3.305–7.138

<0.001

Use of antibiotics, yes

2.355

1.817–3.052

<0.001

30-day mortality	Univariate analysis	Multivariate analysis
Quartiles of UA
Q1 (UA⩽5.0 mg/dl)	1.000			1.000
Q2 (5.1 mg/dl⩽UA⩽6.2 mg/dl)	0.754	0.452–1.259	0.291	0.916	0.498–1.685	0.778
Q3 (6.3 mg/dl⩽UA⩽7.6 mg/dl)	1.738	1.126–2.683	0.013	1.375	0.807–2.344	0.241
Q4 (UA⩾7.7 mg/dl)	3.248	2.176–4.848	<0.001	1.856	1.140–3.022	0.013
Adjusting factors
Configuration factors of APACHE II score
GCS (per one-point increase)	1.263	1.230–1.297	<0.001	1.052	1.006–1.101	0.025
MBP (per one-point increase)	1.665	1.518–1.826	<0.001
Pulse (per one-point increase)	1.732	1.575–1.906	<0.001	1.151	1.014–1.307	0.030
Respiratory rate (per one-point increase)	1.954	1.801–2.121	<0.001	1.381	1.212–1.574	<0.001
Body temperature (per one-point increase)	2.071	1.705–2.515	<0.001	1.367	1.040–1.796	0.025
WBC (per one-point increase)	1.830	1.482–2.260	<0.001	1.402	1.065–1.845	0.016
Hematocrit (per one-point increase)	1.231	1.077–1.406	0.002
Creatinine (per one-point increase)	1.287	1.186–1.397	<0.001	1.265	1.130–1.416	<0.001
Sodium (per one-point increase)	1.896	1.511–2.381	<0.001	1.491	1.109–2.004	0.008
Potassium (per one-point increase)	1.556	1.395–1.736	<0.001
PO₂ (per one-point increase)	1.383	1.269–1.507	<0.001
pH (per one-point increase)	1.771	1.630–1.924	<0.001
Age (per one-point increase)	1.105	1.018–1.199	0.017	1.180	1.052–1.323	0.005
CHP (per one-point increase)	1.251	0.993–1.575	0.057	1.282	0.981–1.675	0.069
Treatment strategy
Performed CPR, yes	13.815	10.052–18.986	<0.001	1.751	1.017–3.014	0.043
Use of vasopressors, yes	12.235	9.032–16.574	<0.001	4.857	3.305–7.138	<0.001
Use of antibiotics, yes	2.355	1.817–3.052	<0.001

Table 3.

Open in new tab

The multivariate logistic model of the clinical findings associated with 30-day cumulative mortality.

30-day mortality	Univariate analysis			Multivariate analysis
	OR	95% CI	p value	OR	95% CI	p value
Quartiles of UA
Q1 (UA⩽5.0 mg/dl)	1.000			1.000
Q2 (5.1 mg/dl⩽UA⩽6.2 mg/dl)	0.754	0.452–1.259	0.291	0.916	0.498–1.685	0.778
Q3 (6.3 mg/dl⩽UA⩽7.6 mg/dl)	1.738	1.126–2.683	0.013	1.375	0.807–2.344	0.241
Q4 (UA⩾7.7 mg/dl)	3.248	2.176–4.848	<0.001	1.856	1.140–3.022	0.013
Adjusting factors
Configuration factors of APACHE II score
GCS (per one-point increase)	1.263	1.230–1.297	<0.001	1.052	1.006–1.101	0.025
MBP (per one-point increase)	1.665	1.518–1.826	<0.001
Pulse (per one-point increase)	1.732	1.575–1.906	<0.001	1.151	1.014–1.307	0.030
Respiratory rate (per one-point increase)	1.954	1.801–2.121	<0.001	1.381	1.212–1.574	<0.001
Body temperature (per one-point increase)	2.071	1.705–2.515	<0.001	1.367	1.040–1.796	0.025
WBC (per one-point increase)	1.830	1.482–2.260	<0.001	1.402	1.065–1.845	0.016
Hematocrit (per one-point increase)	1.231	1.077–1.406	0.002
Creatinine (per one-point increase)	1.287	1.186–1.397	<0.001	1.265	1.130–1.416	<0.001
Sodium (per one-point increase)	1.896	1.511–2.381	<0.001	1.491	1.109–2.004	0.008
Potassium (per one-point increase)	1.556	1.395–1.736	<0.001
PO₂ (per one-point increase)	1.383	1.269–1.507	<0.001
pH (per one-point increase)	1.771	1.630–1.924	<0.001
Age (per one-point increase)	1.105	1.018–1.199	0.017	1.180	1.052–1.323	0.005
CHP (per one-point increase)	1.251	0.993–1.575	0.057	1.282	0.981–1.675	0.069
Treatment strategy
Performed CPR, yes	13.815	10.052–18.986	<0.001	1.751	1.017–3.014	0.043
Use of vasopressors, yes	12.235	9.032–16.574	<0.001	4.857	3.305–7.138	<0.001
Use of antibiotics, yes	2.355	1.817–3.052	<0.001

30-day mortality	Univariate analysis			Multivariate analysis
	OR	95% CI	p value	OR	95% CI	p value
Quartiles of UA
Q1 (UA⩽5.0 mg/dl)	1.000			1.000
Q2 (5.1 mg/dl⩽UA⩽6.2 mg/dl)	0.754	0.452–1.259	0.291	0.916	0.498–1.685	0.778
Q3 (6.3 mg/dl⩽UA⩽7.6 mg/dl)	1.738	1.126–2.683	0.013	1.375	0.807–2.344	0.241
Q4 (UA⩾7.7 mg/dl)	3.248	2.176–4.848	<0.001	1.856	1.140–3.022	0.013
Adjusting factors
Configuration factors of APACHE II score
GCS (per one-point increase)	1.263	1.230–1.297	<0.001	1.052	1.006–1.101	0.025
MBP (per one-point increase)	1.665	1.518–1.826	<0.001
Pulse (per one-point increase)	1.732	1.575–1.906	<0.001	1.151	1.014–1.307	0.030
Respiratory rate (per one-point increase)	1.954	1.801–2.121	<0.001	1.381	1.212–1.574	<0.001
Body temperature (per one-point increase)	2.071	1.705–2.515	<0.001	1.367	1.040–1.796	0.025
WBC (per one-point increase)	1.830	1.482–2.260	<0.001	1.402	1.065–1.845	0.016
Hematocrit (per one-point increase)	1.231	1.077–1.406	0.002
Creatinine (per one-point increase)	1.287	1.186–1.397	<0.001	1.265	1.130–1.416	<0.001
Sodium (per one-point increase)	1.896	1.511–2.381	<0.001	1.491	1.109–2.004	0.008
Potassium (per one-point increase)	1.556	1.395–1.736	<0.001
PO₂ (per one-point increase)	1.383	1.269–1.507	<0.001
pH (per one-point increase)	1.771	1.630–1.924	<0.001
Age (per one-point increase)	1.105	1.018–1.199	0.017	1.180	1.052–1.323	0.005
CHP (per one-point increase)	1.251	0.993–1.575	0.057	1.282	0.981–1.675	0.069
Treatment strategy
Performed CPR, yes	13.815	10.052–18.986	<0.001	1.751	1.017–3.014	0.043
Use of vasopressors, yes	12.235	9.032–16.574	<0.001	4.857	3.305–7.138	<0.001
Use of antibiotics, yes	2.355	1.817–3.052	<0.001

The scoring of each point was described in the original paper on the APACHE II scoring system.¹⁵

OR: odds ratio; CI: confidence interval; Q: quartile; UA: uric acid; APACHE II: Acute Physiology and Chronic Health Evaluation II; GCS: Glasgow Coma Scale; MBP: mean blood pressure; WBC: white blood cell; CHP: chronic health point; CPR: cardiopulmonary resuscitation.

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