Risk reclassification for the secondary endpoint after adding each clinical score to the hs-cTnT model using dichotomized hs-cTnT (above or below LoD) plus continuous hs-cTnT (per 1 ng/l).
| . | Hs-cTnT vs hs-cTnT + GRACE score . | Hs-cTnT vs hs-cTnT + TIMI risk score . | Hs-cTn vs hs-cTnT + HEART score . | Hs-cTn vs hs-cTnT + Simple clinical score . |
|---|---|---|---|---|
| Early presenters (n = 661) | ||||
| NRI (95% CI) | −0.140 (−0.394 to 0.328) | 0.634 (0.361–0.904) | 0.610 (0.358–0.867) | 1.076 (0.666–1.301) |
| IDI (95% CI) | −0.002 (−0.003 to 0.011) | 0.029 (0.006–0.065) | 0.058 (0.015–0.124) | 0.090 (0.051–0.143) |
| Late presenters (n = 1593) | ||||
| NRI (95% CI) | 0.244 (−0.382 to 0.835) | 0.880 (0.541–1.329) | 0.995 (0.647–1.197) | 0.425 (0.170–1.112) |
| IDI (95% CI) | 0.006 (−0.002 to 0.036) | 0.018 (0.001–0.045) | 0.013 (−0.001 to 0.049) | 0.021 (−0.001 to 0.068) |
| . | Hs-cTnT vs hs-cTnT + GRACE score . | Hs-cTnT vs hs-cTnT + TIMI risk score . | Hs-cTn vs hs-cTnT + HEART score . | Hs-cTn vs hs-cTnT + Simple clinical score . |
|---|---|---|---|---|
| Early presenters (n = 661) | ||||
| NRI (95% CI) | −0.140 (−0.394 to 0.328) | 0.634 (0.361–0.904) | 0.610 (0.358–0.867) | 1.076 (0.666–1.301) |
| IDI (95% CI) | −0.002 (−0.003 to 0.011) | 0.029 (0.006–0.065) | 0.058 (0.015–0.124) | 0.090 (0.051–0.143) |
| Late presenters (n = 1593) | ||||
| NRI (95% CI) | 0.244 (−0.382 to 0.835) | 0.880 (0.541–1.329) | 0.995 (0.647–1.197) | 0.425 (0.170–1.112) |
| IDI (95% CI) | 0.006 (−0.002 to 0.036) | 0.018 (0.001–0.045) | 0.013 (−0.001 to 0.049) | 0.021 (−0.001 to 0.068) |
CI: confidence interval; hs-cTn: high sensitivity cardiac troponin; hs-cTnT: high sensitivity cardiac troponin T; IDI: integrated discrimination improvement; LoD: limit of detection; NRI: continuous net reclassification improvement.
Risk reclassification for the secondary endpoint after adding each clinical score to the hs-cTnT model using dichotomized hs-cTnT (above or below LoD) plus continuous hs-cTnT (per 1 ng/l).
| . | Hs-cTnT vs hs-cTnT + GRACE score . | Hs-cTnT vs hs-cTnT + TIMI risk score . | Hs-cTn vs hs-cTnT + HEART score . | Hs-cTn vs hs-cTnT + Simple clinical score . |
|---|---|---|---|---|
| Early presenters (n = 661) | ||||
| NRI (95% CI) | −0.140 (−0.394 to 0.328) | 0.634 (0.361–0.904) | 0.610 (0.358–0.867) | 1.076 (0.666–1.301) |
| IDI (95% CI) | −0.002 (−0.003 to 0.011) | 0.029 (0.006–0.065) | 0.058 (0.015–0.124) | 0.090 (0.051–0.143) |
| Late presenters (n = 1593) | ||||
| NRI (95% CI) | 0.244 (−0.382 to 0.835) | 0.880 (0.541–1.329) | 0.995 (0.647–1.197) | 0.425 (0.170–1.112) |
| IDI (95% CI) | 0.006 (−0.002 to 0.036) | 0.018 (0.001–0.045) | 0.013 (−0.001 to 0.049) | 0.021 (−0.001 to 0.068) |
| . | Hs-cTnT vs hs-cTnT + GRACE score . | Hs-cTnT vs hs-cTnT + TIMI risk score . | Hs-cTn vs hs-cTnT + HEART score . | Hs-cTn vs hs-cTnT + Simple clinical score . |
|---|---|---|---|---|
| Early presenters (n = 661) | ||||
| NRI (95% CI) | −0.140 (−0.394 to 0.328) | 0.634 (0.361–0.904) | 0.610 (0.358–0.867) | 1.076 (0.666–1.301) |
| IDI (95% CI) | −0.002 (−0.003 to 0.011) | 0.029 (0.006–0.065) | 0.058 (0.015–0.124) | 0.090 (0.051–0.143) |
| Late presenters (n = 1593) | ||||
| NRI (95% CI) | 0.244 (−0.382 to 0.835) | 0.880 (0.541–1.329) | 0.995 (0.647–1.197) | 0.425 (0.170–1.112) |
| IDI (95% CI) | 0.006 (−0.002 to 0.036) | 0.018 (0.001–0.045) | 0.013 (−0.001 to 0.049) | 0.021 (−0.001 to 0.068) |
CI: confidence interval; hs-cTn: high sensitivity cardiac troponin; hs-cTnT: high sensitivity cardiac troponin T; IDI: integrated discrimination improvement; LoD: limit of detection; NRI: continuous net reclassification improvement.
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