Risk reclassification for the primary endpoint after adding each clinical score to the hs-cTnT model using dichotomized hs-cTnT (above or below LoD) plus continuous hs-cTnT (per 1 ng/l).
| . | hs-cTnT vs hs-cTnT + GRACE score . | hs-cTnT vs hs-cTnT + TIMI risk score . | hs-cTn vs hs-cTnT + HEART score . | hs-cTn vs hs-cTnT + Simple clinical score . |
|---|---|---|---|---|
| Early presenters (n = 661) | ||||
| NRI (95% CI) | −0.006 (−0.537 to 0.511) | 0.293 (−0.496 to 0.873) | 0.595 (0.218–1.058) | 0.533 (0.219–1.180) |
| IDI (95% CI) | −0.001 (−0.005 to 0.012) | 0.003 (−0.003 to 0.018) | 0.067 (0.010–0.179) | 0.023 (0.003–0.057) |
| Late presenters (n = 1593) | ||||
| NRI (95% CI) | 0.145 (−0.460 to 0.815) | 0.786 (−0.333 to 1.220) | 0.914 (−0.459 to 1.186) | 0.282 (0.005–1.077) |
| IDI (95% CI) | 0.003 (−0.003 to 0.036) | 0.008 (−0.002 to 0.035) | 0.006 (−0.002 to 0.029) | 0.011 (−0.004 to 0.053) |
| . | hs-cTnT vs hs-cTnT + GRACE score . | hs-cTnT vs hs-cTnT + TIMI risk score . | hs-cTn vs hs-cTnT + HEART score . | hs-cTn vs hs-cTnT + Simple clinical score . |
|---|---|---|---|---|
| Early presenters (n = 661) | ||||
| NRI (95% CI) | −0.006 (−0.537 to 0.511) | 0.293 (−0.496 to 0.873) | 0.595 (0.218–1.058) | 0.533 (0.219–1.180) |
| IDI (95% CI) | −0.001 (−0.005 to 0.012) | 0.003 (−0.003 to 0.018) | 0.067 (0.010–0.179) | 0.023 (0.003–0.057) |
| Late presenters (n = 1593) | ||||
| NRI (95% CI) | 0.145 (−0.460 to 0.815) | 0.786 (−0.333 to 1.220) | 0.914 (−0.459 to 1.186) | 0.282 (0.005–1.077) |
| IDI (95% CI) | 0.003 (−0.003 to 0.036) | 0.008 (−0.002 to 0.035) | 0.006 (−0.002 to 0.029) | 0.011 (−0.004 to 0.053) |
CI: confidence interval; hs-cTn: high sensitivity cardiac troponin; hs-cTnT: high sensitivity cardiac troponin T; IDI: integrated discrimination improvement; LoD: limit of detection; NRI: continuous net reclassification improvement.
Risk reclassification for the primary endpoint after adding each clinical score to the hs-cTnT model using dichotomized hs-cTnT (above or below LoD) plus continuous hs-cTnT (per 1 ng/l).
| . | hs-cTnT vs hs-cTnT + GRACE score . | hs-cTnT vs hs-cTnT + TIMI risk score . | hs-cTn vs hs-cTnT + HEART score . | hs-cTn vs hs-cTnT + Simple clinical score . |
|---|---|---|---|---|
| Early presenters (n = 661) | ||||
| NRI (95% CI) | −0.006 (−0.537 to 0.511) | 0.293 (−0.496 to 0.873) | 0.595 (0.218–1.058) | 0.533 (0.219–1.180) |
| IDI (95% CI) | −0.001 (−0.005 to 0.012) | 0.003 (−0.003 to 0.018) | 0.067 (0.010–0.179) | 0.023 (0.003–0.057) |
| Late presenters (n = 1593) | ||||
| NRI (95% CI) | 0.145 (−0.460 to 0.815) | 0.786 (−0.333 to 1.220) | 0.914 (−0.459 to 1.186) | 0.282 (0.005–1.077) |
| IDI (95% CI) | 0.003 (−0.003 to 0.036) | 0.008 (−0.002 to 0.035) | 0.006 (−0.002 to 0.029) | 0.011 (−0.004 to 0.053) |
| . | hs-cTnT vs hs-cTnT + GRACE score . | hs-cTnT vs hs-cTnT + TIMI risk score . | hs-cTn vs hs-cTnT + HEART score . | hs-cTn vs hs-cTnT + Simple clinical score . |
|---|---|---|---|---|
| Early presenters (n = 661) | ||||
| NRI (95% CI) | −0.006 (−0.537 to 0.511) | 0.293 (−0.496 to 0.873) | 0.595 (0.218–1.058) | 0.533 (0.219–1.180) |
| IDI (95% CI) | −0.001 (−0.005 to 0.012) | 0.003 (−0.003 to 0.018) | 0.067 (0.010–0.179) | 0.023 (0.003–0.057) |
| Late presenters (n = 1593) | ||||
| NRI (95% CI) | 0.145 (−0.460 to 0.815) | 0.786 (−0.333 to 1.220) | 0.914 (−0.459 to 1.186) | 0.282 (0.005–1.077) |
| IDI (95% CI) | 0.003 (−0.003 to 0.036) | 0.008 (−0.002 to 0.035) | 0.006 (−0.002 to 0.029) | 0.011 (−0.004 to 0.053) |
CI: confidence interval; hs-cTn: high sensitivity cardiac troponin; hs-cTnT: high sensitivity cardiac troponin T; IDI: integrated discrimination improvement; LoD: limit of detection; NRI: continuous net reclassification improvement.
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